Results 111 to 120 of about 202,020 (287)

Revisiting promising preclinical intracerebral hemorrhage studies to highlight repurposable drugs for translation

, 2020
Intracerebral hemorrhage is a devastating global health burden with limited treatment options and is responsible for 49% of 6.5 million annual stroke-related deaths comparable to ischemic stroke.
Crilly, Siobhan; id_orcid, Kasher, Paul; id_orcid, Parry-Jones, Adrian; id_orcid, Allan, Stuart; id_orcid, Withers, Sarah, Siobhan Crilly, Sarah E Withers, Adrian R Parry-Jones, Stuart M Allan, Paul R Kasher   +9 more
core   +1 more source

Incident heart failure: comparing management and outcome in primary and hospital settings in Western Sweden 2008–2017

ESC Heart Failure, Volume 12, Issue 2, Page 832-838, April 2025.
Abstract Aim Heart failure (HF) is a highly prevalent condition managed in both primary care (PC) and hospital care (HC)‐based settings. HF patients managed in these two settings may differ in their demography, comorbidities and outcomes, so we aimed to compare the patient management in PC and HC in the Västra Götaland Region (VGR) in Sweden.
Xiaojing Chen, Aldina Pivodic, Maria Schaufelberger, Annika Rosengren, Michael Fu   +4 more
wiley   +1 more source

Tumor necrosis factor-α–stimulated gene 6 promotes hematoma clearance after intracerebral hemorrhage in a mouse model

Neural Regeneration Research
The prognosis for patients who experience intracerebral hemorrhage is poor because of a lack of effective treatments. Tumor necrosis factor-α–stimulated gene 6 (TSG6) is a secreted glycoprotein that exerts anti-inflammatory effects in various ...
Xia Liu, Dabao Yao, Yunjie Li, Shiling Chen, Yingxin Tang, Jingyi Wang, Jingfei Yang, Jie Jing, Jiahui Wang, Ge Zhang, Luwei Nie, Yangyang Feng, Gaigai Li, Zhouping Tang   +13 more
doaj   +1 more source

Statin use and risk of remote seizure after first new onset status epilepticus

Epilepsia, EarlyView.
Abstract Objective Preclinical evidence supports the role of statins as antiepileptogenic agents. In this study, we investigated the risk of remote unprovoked seizures (RS) according to the use of statin therapy in a cohort of first‐ever status epilepticus (SE) survivors. Methods Retrospective analysis was made of adult patients (age ≥ 14 years) with a
Niccolò Orlandi, Giada Giovannini, Lisa Taruffi, Margherita Burani, Jefe Laureine Ngnintedem Dontsop, Mara Malerba, Simona Scolastico, Laura Madrassi, Leonardo Affronte, Matteo Pugnaghi, Anna Elisabetta Vaudano, Simona Lattanzi, Stefano Meletti   +12 more
wiley   +1 more source

Prognosis of acute symptomatic seizures and impact of prolonged treatment with anti‐seizure medication

Epilepsia, EarlyView.
Abstract Objectives Acute symptomatic epileptic seizures (ASySs) occur in temporal proximity to acute brain insults. Given their low risk of subsequent unprovoked seizures, current guidelines recommend either no treatment with anti‐seizure medication (ASM) or early discontinuation, yet ASM treatment is often continued beyond hospital discharge.
Hannah Traben, Julia Herzig‐Nichtweiß, Lisa Langenbruch, Felix Kohle, Johann O. Pelz, Piergiorgio Lochner, Matthias Wittstock, Albrecht Günther, Angelika Alonso, Marko Blickhan, Silvia Schönenberger, Sascha Berning, Michael P. Malter, Annekatrin Müller, Frauke Röll, Waldemar Gubarev, Kai M. Schubert, Marian Galovic, Maximilian Mönch, Ulrike Grittner, Martin Holtkamp, Farid Salih, Bernd J. Vorderwülbecke, for the IGNITE! Study Group   +23 more
wiley   +1 more source

The Frequency of Recurrence in Primary Hypertensive Intracerebral Hemorrhage

Journal of Research in Medical Sciences, 2006
Background: Primary intracerebral Hemorrhage (PICH) is a devasting illness with high early mortality which causes 10 -12 percent of stroke cases. Survivors of PICH are at risk for recurrence of hemorrhage.
SA Mousavi, SM Nourian, M Zare
doaj  

Conservative treatment : intracerebral hemorrhage

, 2014
Spontaneous intracerebral hemorrhage is often a late consequence of vascular cerebral dysfunction. Potential for recovery, in this case, is limited.
N. Stocchetti
core   +2 more sources

Leukoaraiosis, intracerebral hemorrhage, and arterial hypertension.

, 1990
To investigate whether the observed association of leukoaraiosis with intracerebral hemorrhage is direct or mediated by risk factors, we compared 116 patients with intracerebral hemorrhage confirmed by computed tomography and 155 controls without ...
G P Giordano, G Pracucci, A L Ancona, D Inzitari, M Mascalchi, L Amaducci   +5 more
core   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Prevalence of either ischemic stroke, intracerebral hemorrhage, or subarachnoid hemorrhage on initial non-contrast CT.

Prevalence of either ischemic stroke, intracerebral hemorrhage, or subarachnoid hemorrhage on initial non-contrast CT.
Michel Shamy (5535602), Dean A. Fergusson (7775588), Ryan Daniel Gotesman (18137085), Naomi Niznick (17022525), Dar Dowlatshahi (530114), Ranjeeta Mallick (433727), Brian Dewar (9553159), Risa Shorr (3417194)   +7 more
core   +1 more source