Results 121 to 130 of about 535,404 (320)

Non‐Histone Lactylation: A New Frontier in Cerebral Ischemia‐Reperfusion Injury

Med Research, EarlyView.
ABSTRACT Reperfusion therapy is the mainstay of treatment for ischemic stroke (IS) but frequently exacerbates secondary injury. Following cerebral ischemia and hypoxia, lactate accumulates markedly. Traditionally regarded as a metabolic byproduct, lactate has gained new significance with the discovery of protein lactylation. In addition to experimental
Minghui Tang, Yuying Mo, Zhishan Ling, Yuting Zeng, Qi Zhang, Shuqi Zheng, Shuyang Wen, Yupeng Xiao, Siying Long, Tingting Yang, Qianru Li, Wenjie Shi, Guozhi Huang, Qing Zeng   +13 more
wiley   +1 more source

Emicizumab in Previously Untreated Patients and Minimally Treated Patients With Hemophilia A: A Comparative Study Between Two International Cohorts

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Hemophilia A (HA) is a rare bleeding disorder caused by coagulation factor VIII (FVIII) deficiency. Prophylactic FVIII replacement therapy is essential for preventing bleeds, but it carries a risk of inhibitor development, especially in previously untreated and minimally treated patients (PUPs and MTPs, respectively).
Sarina Levy‐Mendelovich, Tlalit Barhod, Ivan Budnik, Jonathan Lancashire, Jesal Patel, Assaf Arie Barg, Einat Avishai, Rima Dardik, Tami Brutman Barazani, Tami Livnat, Jayashree Motwani, Gili Kenet   +11 more
wiley   +1 more source

Severe Hyponatremia in the Emergency Department Incidence of Cerebral Edema and Risk of Osmotic Demyelination Syndrome

Academic Emergency Medicine, EarlyView.
ABSTRACT Study Objective Treatment strategies in severe hyponatremia aim at rapid sodium correction to prevent or treat cerebral edema but limit sodium rise to prevent osmotic demyelination syndrome (ODS). The true risk of edema or ODS in ED patients is unknown.
Volker Burst, Ramon Rabii, Julian Peto‐Madew, Thorsten Persigehl, Stefan Haneder, Matthias Johannes Hackl, Christoph Hüser, Moritz Trappe, Sadrija Cukoski, Kathrin Möllenhoff, Victor Suárez   +10 more
wiley   +1 more source

Machine Learning‐Based Prediction of Life‐Threatening Complications During Hemodialysis in Hospitalized Patients With Poor General Conditions

Artificial Organs, EarlyView.
A machine learning model using predialysis data predicted sudden events during or after hemodialysis with high accuracy (auROC: 0.889). The key predictors included emergency hospitalization, recent surgery, high heart rate, low albumin levels, and high CRP.
Naotaka Kato, Takeshi Goto, Tomoyuki Ohira, Hirotaka Kinoshita, Kugo Kurokawa, Kouhei Naganuma, Chikako Ohminato, Junko Ogasawara, Shingo Hatakeyama, Yoshihiro Sasaki, Kazuyoshi Hirota, Chikara Ohyama   +11 more
wiley   +1 more source

Amplitude‐Integrated Electroencephalography Signals, Abnormal General Movements and Later Motor Outcome in Preterm Infants

Acta Paediatrica, EarlyView.
ABSTRACT Aim To evaluate the relationship between amplitude‐integrated electroencephalography (aEEG), general movement assessment (GMA) and later motor outcome in preterm infants. Methods This retrospective study analysed data from 274 very preterm infants born at Innsbruck Medical University Hospital. aEEG was performed within 72 h of birth and weekly
Marlene Hammerl, Anna Posod, Maria Sappler, Christina Schreiner, Nina Gande, Vera Neubauer, Ursula Kiechl‐Kohlendorfer, Elke Griesmaier   +7 more
wiley   +1 more source

3D imaging of neuronal inclusions and protein aggregates in human neurodegeneration by multiscale x‐ray phase‐contrast tomography

Brain Pathology, EarlyView.
x‐ray phase‐contrast tomography enabled three‐dimensional, label‐free visualization and quantification of protein aggregates in neurodegenerative diseases with isotropic submicrometer resolution. The study revealed distinct electron density patterns in Lewy bodies, Hirano bodies, granulovacuolar degeneration, and amyloid plaques, highlighting their ...
Jonas Franz, Jakob Reichmann, Marina Eckermann, Thea Würfel, Artur Groh, Syed Fatima Qadri, Katja Schulz, Brit Mollenhauer, Christine Stadelmann, Tim Salditt   +9 more
wiley   +1 more source

Biallelic COL4A2 Variants Associated With Brain Small Vessel Disease and Brain Malformations

Clinical Genetics, EarlyView.
Biallelic COL4A2 variants cause a spectrum of brain abnormalities such as brain small vessel disease (BSVD). We describe two cases—one with cerebrovascular disruption and one with cortical malformations—expanding the recessive phenotype. Protein modeling reveals destabilization by p.(Arg179Cys), reinforcing its pathogenic role and highlighting collagen
Anees Muhammad, Mohammad Sadegh Shams Nosrati, Alireza Dostmohammadi, Reihaneh Khorasanian, Mariasavina Severino, Morteza Doustmohammadi, Francesca Madia, Siddharth Srivastava, Aisling Quinlan, Dario Paladini, Federico Zara, Marcello Scala   +11 more
wiley   +1 more source

Dysregulation of Rho‐Associated Coiled‐Coil Protein Kinase1 Depletes Neural Stem Cell Pool and Impairs Hippocampal Neurogenesis After Traumatic Brain Injury

Cell Proliferation, EarlyView.
Following TBI, hippocampal neurogenesis in mice is impaired and affects cognitive function. This impairment is associated with the upregulation of p‐AKT/AKT mediated by ROCK1. ABSTRACT Traumatic brain injury (TBI) represents a global health burden, often resulting in persistent neurological deficits due to impaired hippocampal neurogenesis ...
Chaoqun Yao, Long Jin, Jun Zhong, Qianying Huang, Zhongwei Bao, Shaolong Zhou, Chaohua Wang, Huanhuan Li, Xiaowei Yuan, Zhen Wang, Ning Du, Jingxuan Yu, Huanran Chen, Xuyang Zhang, Hongfei Ge, Jianheng Wu   +15 more
wiley   +1 more source

Investigating multimorbidity trajectories in people living with MASLD diagnosis: A trajectory analysis using the UK Biobank

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Background Metabolic dysfunction‐associated steatotic liver disease (MASLD) is an emerging global health concern, and its presence increases the risk of multi‐system diseases. This study aimed to investigate the multimorbidity trajectories of chronic diseases in people living with MASLD.
Fang Lu, Hailin Yang, Bingyang She, Qianhui Lu, Yining Bao, Wai‐Kay Seto, William C. W. Wong, Man‐Fung Yuen, Yingli He, Xinyuan He, Fanpu Ji, Lei Zhang   +11 more
wiley   +1 more source

Contributions of 2‐h post‐load glucose, fasting blood glucose and glycosylated haemoglobin elevations to the prevalence of diabetes and pre‐diabetes in adults: A systematic analysis of global data

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Some studies found that the association of fasting blood glucose (FPG) or glycosylated haemoglobin (HbA1c) elevation with diabetic complications was not statistically significant after controlling for the confounding caused by 2‐h post‐load glucose (2hPG) elevation.
Xue Xue, Jiaxuan Li, Wenxiao Zheng, Bingrui Zhang, Shuting Wang, Jiayue Zhang, Zuyao Yang   +6 more
wiley   +1 more source