Results 21 to 30 of about 202,020 (287)

Cyclophilin D-induced mitochondrial impairment confers axonal injury after intracerebral hemorrhage in mice

Neural Regeneration Research, 2023
The mitochondrial permeability transition pore is a nonspecific transmembrane channel. Inhibition of mitochondrial permeability transition pore opening has been shown to alleviate mitochondrial swelling, calcium overload, and axonal degeneration ...
Yang Yang, Kai-Yuan Zhang, Xue-Zhu Chen, Chuan-Yan Yang, Ju Wang, Xue-Jiao Lei, Yu-Lian Quan, Wei-Xiang Chen, Heng-Li Zhao, Li-Kun Yang, Yu-Hai Wang, Yu-Jie Chen, Hua Feng   +12 more
doaj   +1 more source

Intravenous tPA therapy does not worsen acute intracerebral hemorrhage in mice [PDF]

, 2013
Tissue plasminogen activator (tPA) is the only FDA-approved treatment for reperfusing ischemic strokes. But widespread use of tPA is still limited by fears of inadvertently administering tPA in patients with intracerebral hemorrhage (ICH).
Emiri Mandeville, Cianchetti, Flor A., Ken Arai, van Leyen, Klaus, Frieder Schlunk (280822), Eng H. Lo (112154), Kazim Yigitkanli, Chris B Schaffer, Mandeville, Emiri, Yigitkanli, Kazim, Xiaoying Wang, Nathanael L Rosidi, Chris B. Schaffer (155846), Arne Lauer (280824), Fan, Xiang, Eng H Lo, Helmuth Steinmetz (149409), Rosidi, Nathanael L., Xiang Fan (280830), Schlunk, Frieder, Frieder Schlunk, Flor A. Cianchetti (280825), Wang, Xiaoying, Christian Foerch (149410), Flor A Cianchetti, Kazim Yigitkanli (280829), Arai, Ken, Förch, Christian, Leyen, Klaus van, Lo, Eng H., Foerch, Christian, Xiang Fan, Schaffer, Chris B., Ken Arai (280828), Klaus van Leyen, Helmuth Steinmetz, Emiri Mandeville (280827), Steinmetz, Helmuth, Christian Foerch, Lo, Eng, Arne Lauer, Nathanael L. Rosidi (280821), Xiaoying Wang (30853), Klaus van Leyen (280831), Lauer, Arne, Lo Eng H., Steinmetz Helmuth, Fan Xiang, Yigitkanli Kazim, Schlunk Frieder, Lauer Arne, Wang Xiaoying, Mandeville Emiri, Cianchetti Flor A., Arai Ken, Schaffer Chris B., Rosidi Nathanael L., van Leyen Klaus, Foerch Christian   +58 more
core   +2 more sources

Intracerebral Hemorrhage Induces Monocyte TNF Signaling in Patients That Is Suppressed by BAF312. [PDF]

Ann Clin Transl Neurol
ABSTRACT Objective Intracerebral hemorrhage (ICH) causes high morbidity and mortality, with neurotoxic inflammation driven by infiltrating monocytes. This study is an in‐depth longitudinal examination of the immune response during the first week of ICH in the presence and absence of the immunomodulatory drug BAF312 (Siponimod).
DeLong JH, Díaz-Pérez S, Sheth KN, Cha JH, Malanga CJ, Wagner PGM, Pezous N, Hanin A, Walsh KB, Hinson HE, Sansing LH.   +10 more
europepmc   +2 more sources

Factors associated with intracerebral hemorrhage after thrombolytic therapy for ischemic stroke pooled analysis of placebo data from the Stroke-Acute Ischemic NXY Treatment (SAINT) I and SAINT II trials [PDF]

, 2009
<p><b>Background and Purpose:</b> A number of factors have been associated with postthrombolysis intracerebral hemorrhage, but these have varied across studies.</p> <p><b>Methods:</b> We examined patients with
Demchuk, A., Lees, K.R., Kasner, S.E., Messe, S.R., Cucchiara, B., Levine, S.R., Lyden, P., Sansing, L., Tanne, D.   +8 more
core   +1 more source

Intracerebral Hemorrhage, Visual Hallucination and COVID-19: What Is the Connection? A Case-Related Review of the Literature on Peduncular Hallucinosis Following Intracerebral Hemorrhage [PDF]

, 2021
Previous publications have discussed the occurrence of intracerebral hemorrhages, hallucinations and psychosis in COVID-19 patients. In this article, we have reviewed the literature on the subject while depicting the case of a 63-year-old female patient ...
Nicolas M. Nagysomkuti Mertse, Lisa Zenorini, Zenorini, Lisa, Nagysomkuti Mertse, Nicolas M., René Müri, Müri, René   +5 more
core   +2 more sources

Increased microvascular permeability and low level of low-density lipoprotein cholesterol predict symptomatic intracerebral hemorrhage in acute ischemic stroke

Science Progress, 2020
Symptomatic intracerebral hemorrhage is a serious potential complication of recombinant tissue-type plasminogen activator thrombolysis in acute ischemic stroke.
Tingting Yuan, Naifei Chen, Hang Jin, Hongmei Yin   +3 more
doaj   +1 more source

Relationship Between Intracerebral Hemorrhage and Diabetes Mellitus: A Case-Control Study [PDF]

Journal of Clinical and Diagnostic Research, 2015
Introduction: The role of diabetes mellitus in the pathogenesis of intracerebral hemorrhage (ICH) is controversial. Underlying comorbidities such as diabetes mellitus may increase the risk of intracerebral hemorrhage.
Omid Hesami, Hosein Delavar Kasmaei, Fateme Matini, Farhad Assarzadegan , Behnam Mansouri, Sayena Jabbehdari   +5 more
doaj   +1 more source

Induced neural stem cells suppressed neuroinflammation by inhibiting the microglial pyroptotic pathway in intracerebral hemorrhage rats

iScience, 2023
Summary: Intracerebral hemorrhage usually manifests as strong neuroinflammation and neurological deficits. There is an urgent need to explore effective methods for the treatment of intracerebral hemorrhage.
Jiaxin Liu, Chuanshang Cao, Yiran Jin, Yan Wang, Xiaona Ma, Jiahui Li, Songlin Guo, Jiancheng Yang, Jianguo Niu, Xueyun Liang   +9 more
doaj   +1 more source

Blood levels of Glial Fibrillary Acidic Protein (GFAP) in patients with neurological diseases [PDF]

, 2013
Background and Purpose: The brain-specific astroglial protein GFAP is a blood biomarker candidate indicative of intracerebral hemorrhage in patients with symptoms suspicious of acute stroke.
Niessner, Marion, Robert Brunkhorst, Brunkhorst, Robert, Helmuth Steinmetz, Steinmetz, Helmuth, Marion Niessner, Mayer, Christoph, Christian Foerch, Pfeilschifter, Waltraud, Christoph A Mayer, Förch, Christian, Waltraud Pfeilschifter   +11 more
core   +2 more sources

Safety and tolerability of NXY-059 for acute intracerebral hemorrhage: the CHANT trial [PDF]

, 2007
<p><b>Background and Purpose:</b> NXY-059 is a free radical-trapping neuroprotectant developed for use in acute ischemic stroke. To facilitate prompt administration of treatment, potentially before neuroimaging, we investigated the ...
Lyden, P.D., Hardemark, H.-G., Svensson, H.H., Rodichok, L., Davalos, A., Ashwood, T.J., Ahlberg, G., Lees, K.R., Diener, H.-C., Shuaib, A., Davis, S.M., Grotta, J.C., Wasiewski, W.W.   +12 more
core   +1 more source