Results 21 to 30 of about 67,933 (309)

Relationship Between Intracerebral Hemorrhage and Diabetes Mellitus: A Case-Control Study [PDF]

Journal of Clinical and Diagnostic Research, 2015
Introduction: The role of diabetes mellitus in the pathogenesis of intracerebral hemorrhage (ICH) is controversial. Underlying comorbidities such as diabetes mellitus may increase the risk of intracerebral hemorrhage.
Omid Hesami, Hosein Delavar Kasmaei, Fateme Matini, Farhad Assarzadegan , Behnam Mansouri, Sayena Jabbehdari   +5 more
doaj   +1 more source

Induced neural stem cells suppressed neuroinflammation by inhibiting the microglial pyroptotic pathway in intracerebral hemorrhage rats

iScience, 2023
Summary: Intracerebral hemorrhage usually manifests as strong neuroinflammation and neurological deficits. There is an urgent need to explore effective methods for the treatment of intracerebral hemorrhage.
Jiaxin Liu, Chuanshang Cao, Yiran Jin, Yan Wang, Xiaona Ma, Jiahui Li, Songlin Guo, Jiancheng Yang, Jianguo Niu, Xueyun Liang   +9 more
doaj   +1 more source

Gavestinel does not improve outcome after acute intracerebral hemorrhage: an analysis from the GAIN International and GAIN Americas studies [PDF]

, 2005
<p><b>Background and Purpose:</b> Glycine Antagonist in Neuroprotection (GAIN) International and GAIN Americas trials were prospectively designed, randomized, placebo-controlled trials of gavestinel, a glycine-site antagonist and ...
Lees, K.R., Brown, D.L., Levin, B., Pittman, J.G., Ordronneau, P., Sacco, R.L., Davis, S., Derosa, J.T., Thompson, J.L.P., Haley, E.C.   +9 more
core   +1 more source

Intravenous tPA therapy does not worsen acute intracerebral hemorrhage in mice [PDF]

, 2013
Tissue plasminogen activator (tPA) is the only FDA-approved treatment for reperfusing ischemic strokes. But widespread use of tPA is still limited by fears of inadvertently administering tPA in patients with intracerebral hemorrhage (ICH).
Emiri Mandeville, Cianchetti, Flor A., Ken Arai, van Leyen, Klaus, Frieder Schlunk (280822), Eng H. Lo (112154), Kazim Yigitkanli, Chris B Schaffer, Mandeville, Emiri, Yigitkanli, Kazim, Xiaoying Wang, Nathanael L Rosidi, Chris B. Schaffer (155846), Arne Lauer (280824), Fan, Xiang, Eng H Lo, Helmuth Steinmetz (149409), Rosidi, Nathanael L., Xiang Fan (280830), Schlunk, Frieder, Frieder Schlunk, Flor A. Cianchetti (280825), Wang, Xiaoying, Christian Foerch (149410), Flor A Cianchetti, Kazim Yigitkanli (280829), Arai, Ken, Förch, Christian, Leyen, Klaus van, Lo, Eng H., Foerch, Christian, Xiang Fan, Schaffer, Chris B., Ken Arai (280828), Klaus van Leyen, Helmuth Steinmetz, Emiri Mandeville (280827), Steinmetz, Helmuth, Christian Foerch, Lo, Eng, Arne Lauer, Nathanael L. Rosidi (280821), Xiaoying Wang (30853), Klaus van Leyen (280831), Lauer, Arne   +44 more
core   +1 more source

Safety and tolerability of NXY-059 for acute intracerebral hemorrhage: the CHANT trial [PDF]

, 2007
<p><b>Background and Purpose:</b> NXY-059 is a free radical-trapping neuroprotectant developed for use in acute ischemic stroke. To facilitate prompt administration of treatment, potentially before neuroimaging, we investigated the ...
Lyden, P.D., Hardemark, H.-G., Svensson, H.H., Rodichok, L., Davalos, A., Ashwood, T.J., Ahlberg, G., Lees, K.R., Diener, H.-C., Shuaib, A., Davis, S.M., Grotta, J.C., Wasiewski, W.W.   +12 more
core   +1 more source

Factors associated with intracerebral hemorrhage after thrombolytic therapy for ischemic stroke pooled analysis of placebo data from the Stroke-Acute Ischemic NXY Treatment (SAINT) I and SAINT II trials [PDF]

, 2009
<p><b>Background and Purpose:</b> A number of factors have been associated with postthrombolysis intracerebral hemorrhage, but these have varied across studies.</p> <p><b>Methods:</b> We examined patients with
Demchuk, A., Lees, K.R., Kasner, S.E., Messe, S.R., Cucchiara, B., Levine, S.R., Lyden, P., Sansing, L., Tanne, D.   +8 more
core   +1 more source

Is hypertension a more frequent risk factor for deep than for lobar supratentorial intracerebral haemorrhage? [PDF]

, 2006
OBJECTIVE: To determine whether evidence from observational studies supports the widely held belief that hypertension is more commonly a risk factor for deep than for lobar supratentorial intracerebral haemorrhage.METHODS: Studies comparing the frequency
Jackson, C. A., Sudlow, C L M; id_orcid, Jackson, Caroline; id_orcid, Sudlow, C. L. M.   +3 more
core   +1 more source

Construction of risk prediction and early warning model for long⁃term hemodialysis patients with secondary intracerebral hemorrhage

Huli yanjiu, 2022
ObjectiveTo explore the risk factors of secondary intracerebral hemorrhage in long⁃term hemodialysis patients，and establish the Nomograph model.MethodsA total of 204 end⁃stage uremia patients who underwent long⁃term hemodialysis were selected as the ...
LI Danni, TAN Jingxin, LI Moqi, HE Wenchang   +3 more
doaj  

P2X7 receptor activation aggravates NADPH oxidase 2-induced oxidative stress after intracerebral hemorrhage

Neural Regeneration Research, 2021
Oxidative stress is a crucial pathological process that contributes to secondary injury following intracerebral hemorrhage. P2X7 receptor (P2X7R), which is activated by the abnormal accumulation of extracellular ATP, plays an important role in the ...
Hong Deng, Ye Zhang, Gai-Gai Li, Hai-Han Yu, Shuang Bai, Guang-Yu Guo, Wen-Liang Guo, Yang Ma, Jia-Hui Wang, Na Liu, Chao Pan, Zhou-Ping Tang   +11 more
doaj   +1 more source

Blood-Brain Barrier Dysfunction in Small Vessel Disease Related Intracerebral Hemorrhage

Frontiers in Neurology, 2018
Background and Purpose: Hypertensive vasculopathy and cerebral amyloid angiopathy are the two most common forms of cerebral small vessel disease.
Whitney M. Freeze, Whitney M. Freeze, Heidi I. L. Jacobs, Heidi I. L. Jacobs, Floris H. B. M. Schreuder, Robert J. van Oostenbrugge, Walter H. Backes, Frans R. Verhey, Catharina J. M. Klijn   +8 more
doaj   +1 more source