Results 31 to 40 of about 202,020 (287)

Is hypertension a more frequent risk factor for deep than for lobar supratentorial intracerebral haemorrhage? [PDF]

, 2006
OBJECTIVE: To determine whether evidence from observational studies supports the widely held belief that hypertension is more commonly a risk factor for deep than for lobar supratentorial intracerebral haemorrhage.METHODS: Studies comparing the frequency
Jackson, C. A., Sudlow, C L M; id_orcid, Jackson, Caroline; id_orcid, Sudlow, C. L. M.   +3 more
core   +1 more source

Mitochondrial Protection and Neural Repair via ROS‐Responsive Biomimetic Nanoparticles in Intracerebral Hemorrhage [PDF]

Advanced science
A ROS‐responsive biomimetic nanoparticle platform co‐delivers DIDS and Mdivi‐1 to protect mitochondria and promote neural repair after intracerebral hemorrhage. By targeting LPAR1/VDAC1‐related mitochondrial dysfunction, the nanotherapy reduces oxidative injury, neuronal apoptosis, and blood‐brain barrier disruption, improving neurological recovery and
Gao L, Peng L, Zheng X, Tan C, Wang C, Xiong Q, Chen W, Yang Z.   +7 more
europepmc   +2 more sources

Construction of risk prediction and early warning model for long⁃term hemodialysis patients with secondary intracerebral hemorrhage

Huli yanjiu, 2022
ObjectiveTo explore the risk factors of secondary intracerebral hemorrhage in long⁃term hemodialysis patients，and establish the Nomograph model.MethodsA total of 204 end⁃stage uremia patients who underwent long⁃term hemodialysis were selected as the ...
LI Danni, TAN Jingxin, LI Moqi, HE Wenchang   +3 more
doaj  

Application of stem cells and exosomes in the treatment of intracerebral hemorrhage: an update

Stem Cell Research & Therapy, 2022
Non-traumatic intracerebral hemorrhage is a highly destructive intracranial disease with high mortality and morbidity rates. The main risk factors for cerebral hemorrhage include hypertension, amyloidosis, vasculitis, drug abuse, coagulation dysfunction,
Jian-feng Zhou, Yu Xiong, Xiaodong Kang, Zhigang Pan, Qiangbin Zhu, Roland Goldbrunner, Lampis Stavrinou, Shu Lin, Weipeng Hu, Feng Zheng, Pantelis Stavrinou   +10 more
doaj   +1 more source

P2X7 receptor activation aggravates NADPH oxidase 2-induced oxidative stress after intracerebral hemorrhage

Neural Regeneration Research, 2021
Oxidative stress is a crucial pathological process that contributes to secondary injury following intracerebral hemorrhage. P2X7 receptor (P2X7R), which is activated by the abnormal accumulation of extracellular ATP, plays an important role in the ...
Hong Deng, Ye Zhang, Gai-Gai Li, Hai-Han Yu, Shuang Bai, Guang-Yu Guo, Wen-Liang Guo, Yang Ma, Jia-Hui Wang, Na Liu, Chao Pan, Zhou-Ping Tang   +11 more
doaj   +1 more source

Blood-Brain Barrier Dysfunction in Small Vessel Disease Related Intracerebral Hemorrhage

Frontiers in Neurology, 2018
Background and Purpose: Hypertensive vasculopathy and cerebral amyloid angiopathy are the two most common forms of cerebral small vessel disease.
Whitney M. Freeze, Whitney M. Freeze, Heidi I. L. Jacobs, Heidi I. L. Jacobs, Floris H. B. M. Schreuder, Robert J. van Oostenbrugge, Walter H. Backes, Frans R. Verhey, Catharina J. M. Klijn   +8 more
doaj   +1 more source

Berberine targets the PI3Kα LYS672 site to suppress the PI3K/Akt/NF-κB axis and modulate microglial functional states after intracerebral hemorrhage

Neurotherapeutics
Microglia-driven neuroinflammation contributes to secondary injury after intracerebral hemorrhage (ICH). Modulating microglial functional states represents a promising therapeutic strategy. Berberine (BBR) has neuroprotective effects, but its role in ICH
Qingli Wang, Xuelong Liu, Yang Liu, Ruixue Wei, Zhe Li, Rabeea Siddique, Pingping Guo, Yun Chen, Huizhen Zhou, Liang Cao, V. Wee Yong, Mengzhou Xue   +11 more
doaj   +1 more source

Establishment of risk prediction model of occurrence of pulmonary embolism in patients with intracerebral hemorrhage

Huli yanjiu, 2023
ObjectiveTo explore risk factors of occurrence of pulmonary embolism in patients with intracerebral hemorrhage，and establish risk prediction model.Methods213 patients with intracerebral hemorrhage accepted by our hospital from July 2017 to October 2019 ...
DENG Tianfang, SHAO Shirong, CHEN Min, WANG Yan, YANG Guanglin   +4 more
doaj  

Astrocyte-derived LAMC1 protects against intracerebral hemorrhage: A novel genetic mechanism maintaining neurovascular integrity

Journal of Advanced Research
Introduction: Intracerebral hemorrhage (ICH) is a devastating stroke subtype, yet the intrinsic mechanisms conferring genetic protection against it remain poorly understood. While risk-associated loci have been identified, the cell-type-specific pathways
Liang Cao, Yanjun Zhang, Wenjun Pi, Rui Zhang, Yi Zhang, V.Wee Yong, Mengzhou Xue   +6 more
doaj   +1 more source

Associations of Clinical Characteristics and Etiology With Death in Hospitalized Chinese Children After Spontaneous Intracerebral Hemorrhage: A Single-Center, Retrospective Cohort Study

Frontiers in Pediatrics, 2021
Objective: We retrospectively analyzed clinical characteristics, etiology, and mortality risk factors in pediatric cases of non-traumatic spontaneous intracerebral hemorrhage.Methods: This study involved children between 29 days and 18 years old with ...
Xiaoyan Huang, Zicheng Cheng, Ye Xu, Lingfan Xia, Zhenxiang Zhan, Tong Xu, Yungang Cao, Zhao Han   +7 more
doaj   +1 more source