Results 71 to 80 of about 524,061 (304)

Delayed Transplantation of Neural Stem Cells Improves Initial Graft Survival after Stroke

Advanced Science, EarlyView.
Delayed transplantation of human iPSC‐derived neural progenitor cells (NPCs) enhances graft survival, proliferation, and axonal sprouting after stroke. Using bioluminescence imaging and histology in a mouse model of stroke, it is shown that NPC delivery at 7 days post‐stroke is more effective than acute transplantation, highlighting the importance of ...
Rebecca Z Weber, Nora H Rentsch, Beatriz Achón Buil, Melanie Generali, Lina R. Nih, Christian Tackenberg, Ruslan Rust   +6 more
wiley   +1 more source

Changes in biomarkers of endothelial function in the blood after intracerebral hemorrhage in rats with type 2 diabetes mellitus

Regulatory Mechanisms in Biosystems, 2021
Clinical evidence suggests that type 2 diabetes mellitus can increase the risk of intracerebral hemorrhage and provocation of neurodegeneration. This study was aimed at evaluating biomarkers of glycemic control, lipid profile, oxidative modification of ...
А. E. Lievykh, V. A. Tkachenko, Y. V. Kharchenko, A. I. Shevtsova, G. A. Ushakova, V. I. Zhyliuk   +5 more
doaj   +1 more source

Transplanting neural stem cells overexpressing miRNA‐21 can promote neural recovery after cerebral hemorrhage through the SOX2/LIN28‐let‐7 signaling pathway

Animal Models and Experimental Medicine, EarlyView.
Abstract Background Intracerebral hemorrhage (ICH) remains a devastating neurological disorder with limited therapeutic options. Neural stem cell (NSC)‐based therapies have emerged as a potential regenerative approach, yet the molecular mechanisms regulating NSC behavior require further elucidation.
Wei Dai, Yongxia Li, Jiarui Du, Gang Shen, Meimei Fan, Zuopeng Su, Fulin Xu, Fang Yuan   +7 more
wiley   +1 more source

Establishment and evaluation of a novel rat model of the fourth ventricle hemorrhage

Animal Models and Experimental Medicine, EarlyView.
In this study, a novel rat model of fourth ventricle hemorrhage was established via autologous blood injection through the foramen of Magendie. Anesthetized rats were positioned in a stereotaxic apparatus with their heads tilted downward at an angle of approximately 20° relative to the vertical axis.
Chuhua Fu, Aoqi Liu, Yijia He, Fei Li, Zhouyang Jiang, Peiwen Guo, Zhi Chen, Yujie Chen, Hua Feng   +8 more
wiley   +1 more source

Incident heart failure: comparing management and outcome in primary and hospital settings in Western Sweden 2008–2017

ESC Heart Failure, Volume 12, Issue 2, Page 832-838, April 2025.
Abstract Aim Heart failure (HF) is a highly prevalent condition managed in both primary care (PC) and hospital care (HC)‐based settings. HF patients managed in these two settings may differ in their demography, comorbidities and outcomes, so we aimed to compare the patient management in PC and HC in the Västra Götaland Region (VGR) in Sweden.
Xiaojing Chen, Aldina Pivodic, Maria Schaufelberger, Annika Rosengren, Michael Fu   +4 more
wiley   +1 more source

Do Clinicians Overestimate the Severity of Intracerebral Hemorrhage?

Stroke, 2019
Background and Purpose— Intracerebral hemorrhage (ICH) has a poorer prognosis than acute ischemic stroke (AIS). However, clinician perception of prognosis may influence treatment decisions and adversely affect outcome. On acute CT, the conspicuity of ICH
E. Tilling, Salwa El Tawil, K. Muir
semanticscholar   +1 more source

Kidney injury in patients with heart failure‐related cardiogenic shock: Results from an international, multicentre cohort study

European Journal of Heart Failure, EarlyView.
Kidney injury in heart failure‐related cardiogenic shock. AKI, acute kidney injury; CI, confidence interval; eCPR, extracorporeal cardiopulmonary resuscitation; eGFR, estimated glomerular filtration rate; HR, hazard ratio; OR, odds ratio; VA‐ECMO, veno‐arterial extracorporeal membrane oxygenation.
Jonas Sundermeyer, Caroline Kellner, Benedikt N. Beer, Lisa Besch, Angela Dettling, Letizia Fausta Bertoldi, Stefan Blankenberg, Jeroen Dauw, Dennis Eckner, Ingo Eitel, Tobias Graf, Patrick Horn, Joanna Jozwiak‐Nozdrzykowska, Paulus Kirchhof, Stefan Kluge, Axel Linke, Ulf Landmesser, Enzo Lüsebrink, Nicolas Majunke, Norman Mangner, Sven Möbius Winkler, Peter Nordbeck, Martin Orban, Federico Pappalardo, Matthias Pauschinger, Michal Pazdernik, Alastair Proudfoot, Matthew Kelham, Tienush Rassaf, Hermann Reichenspurner, Clemens Scherer, P. Christian Schulze, Robert H.G. Schwinger, Carsten Skurk, Marek Sramko, Guido Tavazzi, Holger Thiele, Luca Villanova, Nuccia Morici, Ephraim B. Winzer, Dirk Westermann, Benedikt Schrage   +41 more
wiley   +1 more source

Effect of stereo‐EEG versus subdural EEG on functional and seizure outcome in pediatric and adult epilepsy surgery: A 21‐year single‐center experience

Epileptic Disorders, EarlyView.
Abstract Objective (1) To compare use, benefits, and complications of stereo‐EEG (SEEG) and subdural EEG (SD) in presurgical epilepsy candidates. (2) To evaluate the effectiveness of both methods in delineation of the epileptogenic zone (EZ) and guiding tailored resective surgery. Methods We included patients with SEEG or SD evaluations in children and
Ahmed Gaballa, Christian G. Bien, Philip Grewe, Anne Hagemann, Thilo Kalbhenn, Tilman Polster, Friedrich G. Woermann, Thomas Cloppenborg   +7 more
wiley   +1 more source

Pathophysiological Mechanisms and Potential Therapeutic Targets in Intracerebral Hemorrhage

Frontiers in Pharmacology, 2019
Intracerebral hemorrhage (ICH) is a subtype of hemorrhagic stroke with high mortality and morbidity. The resulting hematoma within brain parenchyma induces a series of adverse events causing primary and secondary brain injury.
Zhiwei Shao, Sheng Tu, Anwen Shao
semanticscholar   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source