Results 181 to 190 of about 1,086,069 (255)

Peripheral κ opioid receptor in pain and inflammation: From molecular signalling and gene expression to drug discovery

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 17, Page 5157-5189, September 2026.
The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan   +3 more
wiley   +1 more source

Treating Chronic, Intractable Pain with a Miniaturized Spinal Cord Stimulation System: 1-Year Outcomes from the AUS-nPower Study During the COVID-19 Pandemic. [PDF]

open access: yesJ Pain Res
Salmon J   +13 more
europepmc   +1 more source

Real‐World Evidence of the Effectiveness and Safety of Biosynthetic Semaglutide in Type 2 Diabetes: A Multicentre Study From Pakistan

open access: yesDiabetes, Obesity and Metabolism, Volume 28, Issue 9, Page 8438-8451, September 2026.
ABSTRACT Aims To evaluate the real‐world effectiveness, safety and patient‐reported outcomes of biosynthetic semaglutide in adults with type 2 diabetes mellitus (T2DM) receiving routine outpatient care in a cost‐constrained setting. Methods This 30‐week, prospective, multicentre, non‐interventional study enrolled adults with T2DM initiating ...
Arshad Hussain   +9 more
wiley   +1 more source

Treatment Goals for Primary Biliary Cholangitis, an Australian Perspective

open access: yesJournal of Gastroenterology and Hepatology, Volume 41, Issue 9, Page 2623-2638, September 2026.
ABSTRACT Primary biliary cholangitis (PBC) is an autoimmune liver disease that targets the small intrahepatic bile ducts with diagnosis based on elevated serum alkaline phosphatase (ALP) levels and the presence of anti‐mitochondrial antibodies. Untreated, it may run a progressive course to cirrhosis and hepatic decompensation, at which point liver ...
Simone I. Strasser   +6 more
wiley   +1 more source

Dynamic Probit Models With Network Interdependence and Unobserved Heterogeneity With an Application to Multinational‐Firm Participation in China

open access: yesJournal of Regional Science, Volume 66, Issue 4, Page 1265-1297, September 2026.
ABSTRACT In many areas of regional/spatial economics, we are faced with analyzing discrete dynamic choice problems of economic agents interacting with some network structure through general equilibrium, input‐output links, or strategic interaction. Stochastic estimating equations for such problems can be difficult for many practitioners to estimate ...
Peter H. Egger, Michaela Kesina
wiley   +1 more source

Unstructured Purity

open access: yesNoûs, Volume 60, Issue 3, Page 685-697, September 2026.
ABSTRACT Purity is the principle that fundamental facts only have fundamental constituents. In recent years, it has played a significant (if sometimes implicit) role in metaphysical theorizing. A philosopher will argue that a fact [p]$[p]$ contains a derivative entity and cite Purity as a reason to deny that [p]$[p]$ is fundamental. I argue that recent
Samuel Z. Elgin
wiley   +1 more source

Application of Three‐Dimensionally Printed Surgical Guides in Precise Sacral Tumor Excision and Defect Reconstruction

open access: yesOrthopaedic Surgery, Volume 18, Issue 9, Page 1847-1860, September 2026.
Patient‐specific 3D‐printed guiding templates significantly improve surgical precision and efficiency in complex sacral tumor resection and reconstruction compared to conventional freehand techniques. This computer‐assisted workflow reduces operative time, intraoperative blood loss, and fluoroscopy frequency, providing a safer, highly reproducible ...
Yansong Liu   +7 more
wiley   +1 more source

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