Results 91 to 100 of about 49,583 (285)

Regulation of metabolism by miR-378 [PDF]

, 2014
The present invention provides a method of regulating fatty acid metabolism in a cell by contacting the cell with a modulator of miR-378 and/or miR-378* activity or expression.
Carrer, Michele, Olson, Eric N.
core   +1 more source

Lymphatic Abnormalities in Noonan Syndrome Extend Beyond Clinically Apparent Disease

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Lymphatic disease represents a well‐described manifestation of Noonan syndrome (NS), yet the full phenotypic spectrum remains incompletely characterized, especially in asymptomatic individuals. We conducted a cross‐sectional study including 10 individuals with NS (four with peripheral lymphedema and six without) and 10 age‐ and sex‐matched ...
Inger Norlyk Sheyanth, Benjamin Kelly, Sheyanth Mohanakumar, Steffen Ringgaard, Yoav Dori, Irene Kibæk Nielsen, Uffe Birk Jensen, Vibeke Elisabeth Hjortdal   +7 more
wiley   +1 more source

Intradermal immunization of mice with radiation-attenuated sporozoites of Plasmodium yoelii induces effective protective immunity

Malaria Journal, 2010
Background Intravenous injection of mice with attenuated Plasmodium berghei sporozoites induces sterile immunity to challenge with viable sporozoites. Non-intravenous routes have been reported to yield poor immunity.
Kebaier Chahnaz, Voza Tatiana, Vanderberg Jerome P   +2 more
doaj   +1 more source

Activity-dependent silencing reveals functionally distinct itch-generating sensory neurons [PDF]

, 2014
The peripheral terminals of primary sensory neurons detect histamine and non-histamine itch-provoking ligands through molecularly distinct transduction mechanisms.
Bean, Bruce P., Binshtok, Alexander M., Blasl, Felix, Duan, Bo, Gudes, Sagi, Ma, Qiufu, Oh, Seog Bae, Patoski, Haley A. W., Roberson, David P., Robson, Victoria K., Sprague, Jared M., Woolf, Clifford J.   +11 more
core   +1 more source

The Effect of Intradermal Injection of Adreno-Cortical Hormones*

Journal of Investigative Dermatology, 1952
How adreno-corticaj hormones work is largely unknown, but clinical and experimental evidence seems to show that their action is mainly peripheral. Because it is accessible, we decided to observe the action of these hormones on the human skin.
Benjamin, F.B., Cornbleet, T., Grossman, M.I.   +2 more
openaire   +2 more sources

Establishment of a mouse model of propylthiouracil‐induced antineutrophil cytoplasmic antibody‐associated vasculitis

Animal Models and Experimental Medicine, EarlyView.
This graphical abstract summarizes our study in which we established a novel murine model of antineutrophil cytoplasmic antibody (ANCA)‐associated vasculitis. Neutrophil recruitment was induced using thioglycolate, followed by timed administration of propylthiouracil and phorbol 12‐myristate 13‐acetate to generate DNase I‐resistant neutrophil ...
Sakiko Masuda, Momo Uchizawa, Chihiro Terasaka, Takumi Abe, Tetsuro Nakamura, Yuka Nishibata, Yusho Ueda, Daigo Nakazawa, Utano Tomaru, Akihiro Ishizu   +9 more
wiley   +1 more source

The involvement of perivascular spaces or tissues in the facial intradermal brain-targeted delivery

Drug Delivery, 2019
Our previous work indicates the lymphatic network and perivascular spaces or tissues might be involved in the facial intradermal brain-targeted delivery of Evans blue (EB).
Wei Yang, Bing-Hui Jin, Ya-Jing Chen, Chang Cao, Jia-Zhen Zhu, Ying-Zheng Zhao, Xi-Chong Yu, Fan-Zhu Li   +7 more
doaj   +1 more source

Low-volume jet injection for intradermal immunization in rabbits

BMC Biotechnology, 2002
Background This study tested a low-volume (20–30 μl/20–30 μg DNA) jet injection method for intradermal delivery of a DNA vaccine. Jet injection offers the advantages of a needle-less system, low-cost, rapid preparation of the injected DNA solution, and a
Smith Joanne M, Li Minglin, Ren Shuxun, DeTolla Louis J, Furth Priscilla A   +4 more
doaj   +1 more source

The characteristics of collagen‐induced rheumatoid arthritis in macaques and the changes of heart

Animal Models and Experimental Medicine, EarlyView.
The disease progression in CIA macaques was categorized into three stages: IIR (days 14–34): The indicators related to rheumatoid arthritis and the levels of immunoglobulin were all elevated. There was a small amount of joint effusion, edema and mild synovial hyperplasia. No joint swelling was observed by naked eye.
Lei Zhang, Haifeng Jiang, Zhen Xu, Tingyu Dong, Xiaoyi Liu, Shangxue Yan, Jiajie Kuai, Yan Chang, Wei Wei   +8 more
wiley   +1 more source

Cutaneous nociception and neurogenic inflammation evoked by PACAP38 and VIP [PDF]

, 2010
Pituitary adenylate cyclase-activating peptide-38 (PACAP38) and vasoactive intestinal peptide (VIP) belong to the same secretin–glucagon superfamily and are present in nerve fibers in dura and skin.
A Arimura, A Fullerton, A Ottosson, A Rahmann, AM Drewes, AM Strassman, AM Strassman, B Fjellner, BJ Schueren Van der, CJ Dalsgaard, CJ Hovell, D Levy, D Levy, D Roosterman, DA Groneberg, E Schulze, Helle Holst, Henrik Winther Schytz, HW Schytz, J Hannibal, J Raud, J Seebeck, JB Warren, JD Mikkelsen, Jes Olesen, JM Hansen, K Jensen, L Dickson, L Lundeberg, L Odum, Lars Arendt-Nielsen, LH Lassen, LH Lassen, M Huttunen, M Schmelz, M Steinhoff, MA Ghatei, MA Moskowitz, Messoud Ashina, MV Savage, P Anand, P Gazerani, P Gazerani, P Sikand, R Burstein, R Burstein, R Rukwied, SD Brain, T Dickinson, T Wienecke, T Wienecke, TC Fischer, TC Theoharides, U Pedersen-Bjergaard, U Pedersen-Bjergaard   +54 more
core   +1 more source