Results 71 to 80 of about 49,583 (285)

Localized NF‐κB Inhibition Reduces Lipid Nanoparticle‐Associated Inflammation

Advanced Science, EarlyView.
Lipid nanoparticles (LNPs) activate NF‐κB and provoke inflammation that limits therapeutic delivery. By encapsulating selective NF‐κB inhibitors within LNPs, localized suppression of inflammatory signaling is achieved without compromising mRNA expression.
Carolann L. Espy, Jichuan Wu, Serena Omo‐Lamai, Liuqian Wang, Fengyi Dong, Aleksa Milosavljevic, Sarah O'Neill, Taylor Brysgel, Yufei Wang, Michael Zaleski, Emily Wolfe, Rhea Maheshwari, Manthan Patel, Dirk Trauner, Jia Nong, Zhicheng Wang, Jacob S. Brenner   +16 more
wiley   +1 more source

Rejuvenating Effects of Facial Hydrofilling using Restylane Vital

Archives of Plastic Surgery, 2015
Background Morphological changes that accompany aging, such as wrinkles and skin laxity, are particularly prominent on facial skin. Recently, facial rejuvenation using the hydrofilling effect of hyaluronic acid (HA) filler has been employed for ...
Bong Moo Lee, Dong Gil Han, Won Seok Choi   +2 more
doaj   +1 more source

Safety and immune responses after intradermal application of Porcilis PRRS in either the neck or the perianal region. [PDF]

PLoS ONE, 2018
The objective of the present study was to assess safety and immune responses in gilts after intradermal application of Porcilis® PRRS in two different application sites under field conditions. Forty-four gilts were allocated to one of three groups: Gilts
Julia Stadler, Lena Naderer, Lisa Beffort, Mathias Ritzmann, Daniela Emrich, Walter Hermanns, Kerstin Fiebig, Armin Saalmüller, Wilhelm Gerner, Bernadette Glatthaar-Saalmüller, Andrea Ladinig   +10 more
doaj   +1 more source

Intradermal DNA Electroporation Induces Cellular and Humoral Immune Response and Confers Protection against HER2/neu Tumor [PDF]

, 2015
Skin represents an attractive target for DNA vaccine delivery because of its natural richness in APCs, whose targeting may potentiate the effect of vaccination.
AMICI, Augusto, Curcio, Claudia, Hysi, Albana, Iezzi, Manuela, Lamolinara, Alessia, MARCHINI, Cristina, Mariotti, Marianna, Stramucci, Lorenzo   +7 more
core   +5 more sources

A Keratinocyte‐Mast Cell NF‐κB2/CXCL2/IL‐6 Amplification Loop Enhances Cutaneous Antifungal Defense Against C. albicans

Advanced Science, EarlyView.
ABSTRACT Mast cells (MCs), key innate immune sentinels at the host–environment interface, serve as primary responders to invading pathogens. However, their specific contribution to host defense against cutaneous Candida albicans (C. albicans) infection and their synergy with other immune and non‐immune cells remain poorly understood. Here, we show that
Yan Yuan, Manyun Mao, Jiaan Zhang, Zhimin Duan, JiaNing Wang, Yujie Chen, Sihan Chen, Chuting Liang, Xvyue Zhou, Songmei Geng, Min Li, Xu Chen, Ni Lian   +12 more
wiley   +1 more source

The clinical meaning of histamine skin reactivity [PDF]

, 2015
The definition of the “atopic state”, i.e. subjects presenting at least one skin wheal with a minimum diameter of 3 mm induced by an allergen skin-prick test (ASPT), is based on the assumption that wheal size depends entirely on the amount of histamine
BARRETO, Mario, RONCHETTI, ROBERTO
core   +1 more source

OBSERVATIONS ON THE INTRADERMAL AND REPEATED INTRADERMAL INJECTION OF DIPHTHERIA TOXIN WITH REFERENCE TO THE SCHICK TEST [PDF]

Archives of Pediatrics & Adolescent Medicine, 1916
The knowledge of the effect of subcutaneous and, inadvertently, intradermal injection of diphtheria toxin on the cutaneous tissue, is as old as the knowledge of diphtheria antitoxin. It was necessarily one of the first observations made during the process of immunization and of testing out the strength of diphtheria antitoxin.
openaire   +2 more sources

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Hydrodynamic gene delivery in human skin using a hollow microneedle device [PDF]

, 2017
Microneedle devices have been proposed as a minimally invasive delivery system for the intradermal administration of nucleic acids, both plasmid DNA (pDNA) and siRNA, to treat localised disease or provide vaccination.
Birchall, J. C., Coulman, S. A., Dayan, C., Dul, M., Henri, S., Kochba, E., Levin, Y., Malissen, B., O'Mahony, Conor, Porta, P., Serve, J., Stefanidou, M., Wong, F. S.   +12 more
core   +5 more sources

Depletion of p75NTR in Schwann Cells Driven by Inflammation Mediates Cutaneous Pain in Psoriasis

Advanced Science, EarlyView.
Psoriasis‐like inflammation induces proliferation and molecular remodeling of cutaneous Schwann cells, marked by reduced p75NTR and increased NGF expression. IL‐17A promotes this process, whereas Schwann cell‐specific p75NTR overexpression alleviates cutaneous pain in vivo.
Yibo Wang, Linlin Xu, Chenglong Pan, Ruonan Cao, Piao Zeng, Xinxing Lyu, Qingxia Hu, Zhenzhen Yan, Shuhong Huang, Ningning Dang   +9 more
wiley   +1 more source