Results 81 to 90 of about 16,684 (214)

Formulation of hydrophobic peptides for skin delivery via coated microneedles [PDF]

, 2017
Microneedles (MNs) have been investigated as a minimally-invasive delivery technology for a range of active pharmaceutical ingredients (APIs). Various formulations and methods for coating the surface of MNs with therapeutics have been proposed and ...
Birchall, James C., Coulman, Sion A., Dayan, Colin M., Hanna, Stephanie J., Wong, F. Susan, Zhao, Xin   +5 more
core   +2 more sources

Induction of IL‐9‐producing CD8+ T cells by ascochlorin derivatives

British Journal of Pharmacology, Volume 183, Issue 11, Page 3015-3031, June 2026.
A newly synthesised ascochlorin derivative, N184, induces small amounts of IL‐9‐producing CD8+ T cells. N184 improved the survival of CD8+ T cells and enhanced their antitumour activity, partially in an IL‐9‐dependent manner. The antitumour effect was completely dependent on IFNγ secretion rather than the cytotoxic activity of CD8+ T cells.
Natsumi Imano, Mikako Nishida, Miho Tokumasu, Weiyang Zhao, Nahoko Yamashita, Heiichiro Udono   +5 more
wiley   +1 more source

Successful Application of Large Microneedle Patches by Human Volunteers [PDF]

, 2017
We describe, for the first time, the design, production and evaluation of large microneedle patches. Such systems, based on 16 individual microneedle arrays (needle height 600 μm), were prepared from aqueous blends of 15% w/w Gantrez(®) S97 and 7.5% w/w ...
Barry, Johanne, Donnelly, Ryan F., Larrañeta, Eneko, Quinn, James, Ripolin, Anastasia, Vicente-Perez, Eva Maria   +5 more
core   +1 more source

TEAD1 Enhances Exosome Secretion and Promotes Exosome‐Mediated Tissue Regeneration

Advanced Science, Volume 13, Issue 25, 4 May 2026.
TEAD1 functions as a crucial molecular switch regulating exosome secretion in various cell types. TEAD1 enhances exosome secretion by upregulating key proteins associated with exosome secretion, including RAB11, CD9, and SNAP23. This study reveals a novel role for TEAD1 in regulating exosome secretion and tissue regeneration, particularly in diabetic ...
Yan Pu, Yi Wan, Wenhao Shi, Bin Li, Haiyue Zhang, Jun Wu, Lingling Li, Wenjia Guo, Chen Ding, Wenjun Yang   +9 more
wiley   +1 more source

Extra-Pulmonary Tuberculosis Presenting as Established Non-Union Tibia Shaft Fracture [PDF]

National Journal of Laboratory Medicine, 2016
can present extraordinarily as a non-resoluting inflammatory pathology or can even mimic as malignancy especially sarcomatous or metastatic deposits. It sometimes can be diagnostically challenging for both the treating clinician and pathologist.
Tejinder Singh Bhasin, Rahul Mannan, Sonam Sharma, Gagandeep Singh, Gagandeep Singh   +4 more
doaj   +1 more source

Effects of intradermal injection of atrial natriuretic peptide. [PDF]

, 1995
Atrial natriuretic peptide (ANP) causes mast cell degranulation in rats in vivo and in vitro but is bronchodilator in humans. The aim of this study was to investigate the wheal and flare dose-response to intradermal injection of alpha-human ANP in normal
Higham, Ma, Ind, P. W., Sharara, Am, Spanevello, Antonio   +3 more
core   +1 more source

Disc‐Toroid Hybrid Lipid Nanoparticles for Efficient Drug Encapsulation and Subcutaneous Delivery

Small, Volume 22, Issue 26, 8 May 2026.
This study demonstrates sub‐50 nm solid‐lipid nanoparticles with long‐term stability, high drug loading, and strong tissue compatibility. Disc‐toroid morphology is confirmed and may play a role in cellular interactions, while low cytotoxicity and minimal systemic permeation confirm depot‐like behavior. These nanoparticles represent a versatile platform
Zanelle van Niekerk, Rima Nuwayhid, Stefaniya Gaydarova, Eva Bittrich, Natalia Makarova, Susanne Boye, Christo Tzachev, Jan C. Simon, Sandra Franz, Albena Lederer   +9 more
wiley   +1 more source

Safety and immunogenicity of inactivated poliovirus vaccine when given with measles–rubella combined vaccine and yellow fever vaccine and when given via different administration routes: a phase 4, randomised, non-inferiority trial in The Gambia

The Lancet Global Health, 2016
Background: The introduction of the inactivated poliovirus vaccine (IPV) represents a crucial step in the polio eradication endgame. This trial examined the safety and immunogenicity of IPV given alongside the measles–rubella and yellow fever vaccines at
Dr. Ed Clarke, MBChB, Yauba Saidu, MD, Jane U Adetifa, MD, Ikechukwu Adigweme, MBBS, Mariama Badjie Hydara, MBBS, Adedapo O Bashorun, MBBS, Ngozi Moneke-Anyanwoke, MBBS, Ama Umesi, MBBS, Elishia Roberts, BSc, Pa Modou Cham, BSc, Michael E Okoye, MBBS, Kevin E Brown, MBBS, Prof. Matthias Niedrig, PhD, Panchali Roy Chowdhury, MSc, Ralf Clemens, MD, Ananda S Bandyopadhyay, MBBS, Jenny Mueller, MD, David J Jeffries, PhD, Prof. Beate Kampmann, MD   +18 more
doaj   +1 more source

Allogeneic Stem Cells Alter Gene Expression and Improve Healing of Distal Limb Wounds in Horses. [PDF]

, 2017
Distal extremity wounds are a significant clinical problem in horses and humans and may benefit from mesenchymal stem cell (MSC) therapy. This study evaluated the effects of direct wound treatment with allogeneic stem cells, in terms of gross, histologic,
Aristizobal, Fabio A, Bledsoe, Andrea, Bohannon-Worsley, Laurie K, Borjesson, Dori L, Clark, Kaitlin C, Davidyan, Arik, Gray, Sarah N, Kol, Amir, LeJeune, Sarah S, Textor, Jamie A, Walker, Naomi J, Woolard, Kevin D   +11 more
core   +1 more source

Atypical metastatic osteosarcoma pattern in a dog: Lymphatic, neurovascular and subcutaneous metastasis

Veterinary Record Case Reports, Volume 14, Issue 2, May 2026.
Abstract A 6‐year‐old, spayed, female labrador retriever was presented with left distal radial swelling. Imaging, cytology and biopsy identified an aggressive radial lesion with metastasis to the left axillary lymph node, and a diagnosis of presumptive osteosarcoma was made.
Veronica Perez‐Rodriguez, Laura Venner, Rowan Milner, Jishnu Rao Gutti, Elizabeth A. Maxwell   +4 more
wiley   +1 more source