Results 111 to 120 of about 51,047 (183)

PHLPP is neither a Phosphatase nor a Tumor Suppressor

BioEssays, Volume 48, Issue 7, July 2026.
PH domain leucine‐rich repeat protein phosphatases (PHLPP) have been described as Akt phosphatases and tumor suppressors for more than 20 years. Recent evidence, however, indicates that they are pseudophosphatases that lost catalytic activity more than 450 Mya. This article argues that new hypotheses are urgently needed to reorient the field.
Thomas A. Leonard
wiley   +1 more source

Detection of HPV DNA in Cervical Intraepithelial Neoplasia Using In Situ Hybridization. [PDF]

J Clin Med
Przybylski M, Millert-Kalińska S, Pruski D, de Mezer M, Krzyżaniak M, Jach R, Żurawski J, Kurzawa P.   +7 more
europepmc   +1 more source

Analysis of Age, Period and Cohort Trends in Cervical In Situ and Invasive Carcinomas for Assessing the Utility of Screening Approaches—Results From the Saarland Cancer Registry

Cancer Medicine, Volume 15, Issue 7, July 2026.
ABSTRACT Background Cervical cancer continues to pose a significant public health burden. In Germany, prevention relies heavily on regular screening and HPV vaccination. Objective To analyze trends in cervical cancer incidence over a 50‐year period in Saarland, Germany, with a focus on cohort effects and the impact of screening programs.
Natalie Rath, Klaus Neis, Bernd Holleczek   +2 more
wiley   +1 more source

Response to progestin-based therapy in endometrial intraepithelial neoplasia: An exploratory biomarker study. [PDF]

Gynecol Oncol Rep
Seay K, Hare M, Cao J, Katcher A, Akerman M, Beyaz S, Goldberg GL, Frimer M.   +7 more
europepmc   +1 more source

Cervical Metastasis From Primary Breast Carcinoma: A Case Report and Review of Extragenital Tumors Involving the Uterine Cervix

Clinical Case Reports, Volume 14, Issue 7, July 2026.
ABSTRACT Cervical metastases from breast carcinoma should be considered in the differential diagnosis of uterine lesions in patients with prior breast cancer. Re‐biopsy is essential to detect receptor discordance (ER/PR up to 29%) and guide therapy. GCDFP‐15, mammaglobin, and GATA3 confirm mammary origin.
Mario Assenza, Adele Zappalà, Armando Nallbani, Jacopo Wabersich   +3 more
wiley   +1 more source

Establishing a nomogram on the risk of pathological escalation of intestinal intraepithelial neoplasia in patients with colorectal intraepithelial neoplasia: a retrospective study. [PDF]

Front Med (Lausanne)
Zhang C, Lu L, Wu S, Jin S.
europepmc   +1 more source

Acute Drug‐Induced Liver Injury After Four Doses of Nitrofurantoin, as Evaluated for Causality Using the Updated RUCAM, With a Disproportionate Rise in AST—A Novel Case Report

Clinical Case Reports, Volume 14, Issue 7, July 2026.
ABSTRACT Drug‐induced liver injury remains a severe but underdiscussed adverse effect of nitrofurantoin. This case uniquely describes hepatic injury occurring after four doses of nitrofurantoin, with a disproportionate rise in AST and rapid complete recovery following discontinuation of the drug. A RUCAM score of six supports the probability of DILI.
Mahir H. Sampat
wiley   +1 more source

Choledochal Villous Adenoma With Intrahepatic Bile Duct Stones: A Case Report

Clinical Case Reports, Volume 14, Issue 7, July 2026.
ABSTRACT This report describes a 58‐year‐old female with prior biliary surgery who presented with a choledochal villous adenoma and intrahepatic stones. The lesion showed high‐grade intraepithelial neoplasia, indicating malignant potential. She underwent left hemihepatectomy, choledochectomy, and Roux‐en‐Y hepaticojejunostomy, with no recurrence at 4 ...
Hao Li, Shaohua Sun, Wenbo Zhou
wiley   +1 more source

Conjunctival Intraepithelial Neoplasia With IgG and Complement Deposition: Spurious Association or Biologically Explainable? [PDF]

Cureus
Zhang DD, Raja D, Cheung WL, Margo CE.
europepmc   +1 more source

From Inflammatory Bowel Disease to Cancer: Gut Microbiota–Immune Microenvironment Crosstalk and Natural Product‐Based Therapeutic Opportunities

Cancer Nexus, Volume 2, Issue 3, July 2026.
ABSTRACT Inflammatory bowel disease (IBD), primarily Crohn's disease and ulcerative colitis, is a chronic relapsing inflammatory disorder of the gastrointestinal tract and an important risk factor for IBD‐associated cancer. Increasing evidence suggests that gut microbiota dysbiosis, epithelial barrier dysfunction, and immune microenvironment remodeling
Xue Zhang, Chongchong Gao, Rui Jiang, Zijian Wu, Jian Bai   +4 more
wiley   +1 more source