Results 91 to 100 of about 51,047 (183)

Unveiling the molecular profile of adenosquamous gallbladder carcinoma: characterization of a Caucasian cohort

Histopathology, EarlyView.
GBASCs are MMRp tumours, exhibiting minimal HER2 overexpression and elevated PD‐L1 expression compared to adenocarcinomas. Especially in metastatic and TP53‐wild type tumours, GBASCs can express CLDN18, albeit limited to the glandular component. Their genomic profile resembles that of adenocarcinomas with an enrichment in alterations on PIK3CA, PTEN ...
Jessica Gasparello, Valentina Angerilli, Mario Domenico Rizzato, Edoardo Maffii, Carlotta Ceccon, Matilde Callegarin, Marianna Sabbadin, Monia Niero, Luisa Toffolatti, Francesca Bergamo, Paola Parente, Luca Mastracci, Federica Grillo, Alessandro Vanoli, Paola Mattiolo, Claudio Luchini, Angelo Paolo Dei Tos, Umberto Cillo, Giacomo Zanus, Sara Lonardi, Matteo Fassan   +20 more
wiley   +1 more source

Spatial transcriptomics reveals clonal relationships between intraductal carcinoma and adjacent invasive prostate cancer

Histopathology, EarlyView.
Spatial transcriptomics of six prostate samples reveals a close clonal relationship between high‐grade Prostatic Intraepithelial Neoplasia (HGPIN), Intraductal carcinoma (IDC) and adjacent invasive glands. In three samples, adjacent invasive glands had more copy number variants than HGPIN and IDC. Adjacent invasive glands were also placed at the end of
Hridya Harikumar, Myrthe de Waard‐van Baardwijk, Marit de Haan, Gregory van Beek, Karishma Lila, Martin E van Royen, Thierry PP van den Bosch, Mathijs A Sanders, Eric Bindels, Andrew Stubbs, Geert JLH van Leenders   +10 more
wiley   +1 more source

Prostate Cancer Development, Progression, and Therapy

MedComm – Oncology, Volume 5, Issue 3, September 2026.
This review provides an integrated overview of prostate cancer development, progression, and therapy, spanning historical milestones, molecular mechanisms, advanced research models, and emerging therapeutic strategies. It highlights recent advances in precision diagnosis, lineage plasticity, therapy resistance, and next‐generation treatments for ...
Xin Jin, Zicheng Xiao, Zexian Ding, Wei Li, Ruijiang Zeng, Yujun Shuai, Weimin Ci, Dan Xia, Xu Zhang, Haojie Huang   +9 more
wiley   +1 more source

Risk stratification and anal cancer screening in immunocompetent women with genital HPV: Value of multicentric HSIL and performance of HPV‐based screening

International Journal of Cancer, Volume 159, Issue 4, Page 1017-1027, 15 August 2026.
What's new? Anal squamous cell carcinoma (ASCC) incidence is increasing, with most cases occurring in immunocompetent women. ASCC risk is linked in particular to genital human papillomavirus (HPV) infection and HPV‐associated high‐grade squamous intraepithelial lesions (HSILs).
Isabel Matas, Aureli Torné, Adela Saco, Cristina Martí, Ada Cardiel, Natalia Rakislova, Lorena Marimon, Ariel Glickman, Ingrid Victoria, Silvia Alós, Jesús Lopez‐Diaz, Pere Fusté, Jaume Ordi, Marta del Pino   +13 more
wiley   +1 more source

Results of loop diathermy conization as diagnostic and therapeutic procedure

Acta Médica del Centro, 2014
Introduction: currently broadcasts the use of diathermy handles for the treatment of premalignant lesions of the neck. Objective: to present the results of loop diathermy conization in cervical premalignant lesions.
Yarima Bravo Torres, Yordayka Elda Rivero Ramírez, Yoel Cardet Niebla, Armando Eugenio Iglesias Yera, Fernando Machado Rojas, Sandi Jiménez Puñales   +5 more
doaj  

Infection by the human papillomavirus in teenagers sexually active: clinic and subclinic manifestations

São Paulo Medical Journal
This research studies the association of the cervical condyloma with the intraepithelial neoplasia, during sex activity, pregnancy, diagnose methods, cytology and colposcopy in teenagers.
Sophie Derchain, Jessé de Paula Neves-Jorge, Liliana Andrade, Aarão Mendes Pinto-Neto, João Pinto e Silva   +4 more
doaj   +1 more source

Nationwide Study on the Cervical Cancer Screening Pathway in Estonia

International Journal of Cancer, Volume 159, Issue 4, Page 883-895, 15 August 2026.
Cervical cancer remains a significant burden despite being preventable, largely due to inadequate screening participation and poor follow‐up of high‐risk women. Here, the authors investigated follow‐up rates among women who tested positive for high‐risk human papillomavirus (hr‐HPV) infection in primary screening in Estonia. Data show that more than 57
Aleksandra Šavrova, Helen Jakoby, Anna Tisler, Kaire Innos, Ülo Maiväli, Jana Jaal, Anneli Uusküla   +6 more
wiley   +1 more source

Extended HPV typing as an efficient alternative within HPV‐based screening programs

International Journal of Cancer, Volume 159, Issue 3, Page 638-644, 1 August 2026.
What's New? Extended high‐risk human papillomavirus (hrHPV) typing holds promise for improving cervical intraepithelial neoplasia grade 3 (CIN3) detection, particularly as vaccinated cohorts may shift the prevalence of oncogenic HPV types. The authors of this study evaluated extended hrHPV genotyping within a public screening program involving women ...
Joacim Meneses‐León, Berenice Rivera‐Paredez, Sonia Hernández‐Salazar, Leticia Torres‐Ibarra, Martha Carnalla, Leith León‐Maldonado, Rubí Hernández‐López, José Damián Cadena‐Fiscal, Anna B. Moscicki, Manuel Quiterio‐Trenado, Eduardo Lazcano‐Ponce, Jorge Salmerón   +11 more
wiley   +1 more source

Loop electrosurgical excision procedure and perinatal outcomes post‐human papillomavirus cervical screening: A longitudinal cohort study

International Journal of Gynecology &Obstetrics, Volume 174, Issue 2, Page 793-799, August 2026.
Abstract Objective This study examines the associations between the loop electrosurgical excision procedure (LEEP) and the risk of adverse perinatal outcomes among women who have undergone primary human papillomavirus (HPV) screening. Methods In this longitudinal cohort study, women who received HPV screening and were followed up in a randomized trial ...
Quan Hong, Laurie W. Smith, Lily Proctor, Lovedeep Gondara, Saiful Alam, Darrel Cook, Eduardo L. Franco, Mel Krajden, Ruth Elwood Martin, Elisabeth McClymont, Joy Melnikow, Stuart Peacock, Gavin Stuart, Gina S. Ogilvie, Anna Gottschlich   +14 more
wiley   +1 more source

Mitochondria‐Targeting Moieties Based on N‐Tethered Pyridinium Cations

Angewandte Chemie, Volume 138, Issue 29, 13 July 2026.
Pyridinium cations were benchmarked as mitochondria‐targeting moieties in a panel of N‐tethered fluorescent‐, bioactive‐, and inert‐cargo conjugates. 3,5‐Diphenylpyridinium (DPPy+) is a competent triphenylphosphonium (TPP+) surrogate, combining high mitochondria‐targeting efficiency with lower intrinsic effects on mitochondrial function.
Ivan Džajić, Natalija Trunkelj, Jernej Repas, Maša Kandušer, Lara Smrdel, Stane Pajk, Lovro Žiberna, Irena Mlinarič‐Raščan, Bostjan Markelc, Tim Bozic, Masa Omerzel, Tanja Jesenko, Maja Cemazar, Katja Kološa, Bojana Žegura, Miha Virant, Matic Lozinšek, Hai M. Nguyen, Joshua A. Nasburg, Heike Wulff, Maxime Gueguinou, Valerije Vrček, Veronica Carpanese, Ildiko Szabo, Luis A. Pardo, Tihomir Tomašič, Lucija Peterlin Mašič, Andrej Emanuel Cotman   +27 more
wiley   +2 more sources