Results 51 to 60 of about 5,564 (203)

Absence seizures: Update on signaling mechanisms and networks

Epilepsia Open, EarlyView.
Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley   +1 more source

Functional topography of the thalamo-cortical system during development and its relation to cognition

NeuroImage, 2020
The thalamus has complex connections with the cortex and is involved in various cognitive processes. However, little is known about the age-related changes of thalamo-cortical connections and their relation to cognitive abilities.
Leonie Steiner, Andrea Federspiel, Nedelina Slavova, Roland Wiest, Sebastian Grunt, Maja Steinlin, Regula Everts   +6 more
doaj   +1 more source

Functional and structural connectivity of thalamic subnuclei in major depressive disorder at 7 Tesla

Psychiatry and Clinical Neurosciences, EarlyView.
Aims Major depressive disorder (MDD) is widely considered to be a mood disorder characterized by altered connectivity. The thalamus plays an important role in MDD by connecting large areas of the brain. Here, we explored thalamic connectivity in MDD at the subnuclear level using ultra‐high‐field MRI.
Weijian Liu, Shu Liu, Jurjen Heij, Laurens A. van de Mortel, Luka Liebrand, Matthan Caan, Wietske van der Zwaag, Dick J. Veltman, Lin Lu, Moji Aghajani, Guido van Wingen   +10 more
wiley   +1 more source

Sequential alteration of microglia and astrocytes in the rat thalamus following spinal nerve ligation

Journal of Neuroinflammation, 2018
Background Spinal reactive astrocytes and microglia are known to participate to the initiation and maintenance of neuropathic pain. However, whether reactive astrocytes and microglia in thalamic nuclei that process sensory-discriminative aspects of pain ...
Lucie Blaszczyk, Marlène Maître, Thierry Lesté-Lasserre, Samantha Clark, Daniela Cota, Stéphane H. R. Oliet, Valérie S. Fénelon   +6 more
doaj   +1 more source

Imaging the Centromedian Thalamic Nucleus Using Quantitative Susceptibility Mapping. [PDF]

, 2019
The centromedian (CM) nucleus is an intralaminar thalamic nucleus that is considered as a potentially effective target of deep brain stimulation (DBS) and ablative surgeries for the treatment of multiple neurological and psychiatric disorders.
Gutierrez, Lorenzo, Li, Dianyou, Li, Jun, Li, Yufei, Liu, Chunlei, Sun, Bomin, Wei, Hongjiang, Wu, Yiwen, Xu, Wenying, Zhang, Chencheng   +9 more
core  

Unraveling Chronic Pain: From Mechanisms and Risks to Diagnosis and Treatment

MedComm, Volume 7, Issue 4, April 2026.
Chronic pain arises through distinct molecular pathways categorized into nociceptive, neuropathic, and nociplastic types. Nociceptive pain begins with TRP channel activation in peripheral nociceptors, signaling via Aδ‐ and C‐fibers through the spinal dorsal horn and spinothalamic tracts to the brain, regulated by descending inhibition and involving ...
Xiaofeng Dai, Chongxiang Wang, Ping Jiang, Xiaopeng Mei   +3 more
wiley   +1 more source

Variability and anatomical specificity of the orbitofrontothalamic fibers of passage in the ventral capsule/ventral striatum (VC/VS): precision care for patient-specific tractography-guided targeting of deep brain stimulation (DBS) in obsessive compulsive disorder (OCD) [PDF]

, 2015
Deep Brain Stimulation (DBS) is a neurosurgical procedure that can reduce symptoms in medically intractable obsessive-compulsive disorder (OCD). Conceptually, DBS of the ventral capsule/ventral striatum (VC/VS) region targets reciprocal excitatory ...
Bonmassar, Giorgio, Dougherty, Darin D., Eskandar, Emad N., Fan, Qiuyun, Ing, Wingkwai I., Kubicki, Marek, Makris, Nikolaos, Mouradian, Palig, Nummenmaa, Aapo, Papadimitriou, George, Rathi, Yogesh, Wald, Lawrence L., Widge, Alik, Yeterian, Edward H.   +13 more
core   +1 more source

Emerging Neural Recording and Neurostimulation Technologies Based on Brain–Computer Interface: A Promising Approach for Neuropsychiatric Disorders

MedComm, Volume 7, Issue 4, April 2026.
This review explores brain–computer interface (BCI)–based neural recording and stimulation for treating neuropsychiatric disorders. It details three emerging technologies: endovascular BCI for minimally invasive signal acquisition, BCI‐integrated epidural spinal cord stimulation for motor restoration, and closed‐loop deep brain stimulation for adaptive
Yeguang Xu, Danyang Chen, Qing Ye, Peng Zhang, Jian Shi, Shengjie Li, Yuhao Sun, Zhixian Zhao, Yingxin Tang, Ping Zhang, Zhouping Tang   +10 more
wiley   +1 more source

Seizure-related activity of intralaminar thalamic neurons in a genetic model of absence epilepsy

Neurobiology of Disease, 2011
Absence seizures are characterized by bilateral spike-and-wave discharges (SWDs) in thalamo-cortical circuits. In view of clinical studies indicating a critical involvement of intralaminar thalamic nuclei, we thought it timely to characterize the ...
Ali Gorji, Christoph Mittag, Parviz Shahabi, Thomas Seidenbecher, Hans-Christian Pape   +4 more
doaj   +1 more source

Anatomical Progression of Neuropathology in FTLD‐TDP Type C and Linkage to Annexin A11

Annals of Neurology, Volume 99, Issue 3, Page 639-655, March 2026.
Objective Frontotemporal lobar degenerations (FTLD)‐TDP type C (TDP‐C) is distinguished from other FTLD‐TDP subtypes by 3 unique features: (1) invariable onset in the anterior temporal lobe (ATL), (2) phosphorylated TDP‐43 (pTDP) neurites in cortex, and (3) colocalization of all pTDP deposits with annexin A11 (ANXA11).
Allegra Kawles, Caroline Nelson, Ivan Ayala, Elena Barbieri, Rudolph Castellani, Changiz Geula, Tamar Gefen, M. Marsel Mesulam   +7 more
wiley   +1 more source