Results 61 to 70 of about 140,818 (295)

Intranasal Delivery of Nanoformulations: A Potential Way of Treatment for Neurological Disorders

Molecules, 2020
Although the global prevalence of neurological disorders such as Parkinson’s disease, Alzheimer’s disease, glioblastoma, epilepsy, and multiple sclerosis is steadily increasing, effective delivery of drug molecules in therapeutic quantities to the ...
S. U. Islam, A. Shehzad, Muhammad Bilal Ahmed, Young Sup Lee   +3 more
semanticscholar   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Early intranasal medication administration in out‐of‐hospital cardiac arrest: Two randomized simulation trials

Journal of the American College of Emergency Physicians Open
Objective Intranasal medications have been proposed as adjuncts to out‐of‐hospital cardiac arrest (OHCA) care. We sought to quantify the effects of intranasal medication administration (INMA) in OHCA workflows.
Stephen R. Dowker, Madison L. Downey, Noor K. Majhail, Isabella G. Scott, Jonah Mathisson, Daniel Rizk, Brad Trumpower, Debra Yake, Michelle Williams, Emilee I. Coulter‐Thompson, Christine M. Brent, Graham C. Smith, Robert Swor, David A. Berger, Deborah M. Rooney, Robert W. Neumar, Charles P. Friedman, James M. Cooke, Amanda L. Missel   +18 more
doaj   +1 more source

Intranasal Ketamine for Depression in Adults: A Systematic Review and Meta-Analysis of Randomized, Double-Blind, Placebo-Controlled Trials

Frontiers in Psychology, 2021
BackgroundThere is growing interest in glutamatergic agents as a treatment for depression, especially intranasal ketamine, which has become a hot topic in recent years.
Dongjiao An, Changwei Wei, Jing Wang, Anshi Wu   +3 more
doaj   +1 more source

Programmable DNA‐Peptide Hybrid Nanostructures for Potent Neutralization of Multiple Influenza a Virus Subtypes

Advanced Functional Materials, EarlyView.
A multivalent antiviral platform based on honeycomb‐shaped DNA nanostructures (HC–Urumin) is developed to enhance the potency and breadth of the host defense peptide Urumin. Through spatially patterned trimeric presentation, HC–Urumin disrupts influenza A virus entry, improves cell viability, and reduces disease severity in vivo‐offering a modular and ...
Saurabh Umrao, Abhisek Dwivedy, Payton L. Haak, Dhanush Gandavadi, Laurie A. Rund, Chi Chen, Vineetha Mareddy, Lifeng Zhou, Jinwei Duan, Ying Fang, Andrew J. Steelman, Xing Wang   +11 more
wiley   +1 more source

Targeting the ARRDC3–DRP1 Axis via hUMSC‐Derived Exosomal CRYAB for Neuroprotection in Cerebral Ischemia/Reperfusion Injury

Advanced Healthcare Materials, EarlyView.
Intranasally administered hUMSC‐derived exosomes modulate the CRYAB–ARRDC3–Drp1 axis, alleviating mitochondrial dysfunction and ferroptosis, enhancing neuronal survival, reducing oxidative stress, and promoting functional recovery in ischemia‐reperfusion injury, offering a promising therapeutic strategy for ischemic stroke.
Rong ji, Zengyu Zhang, Zhuohang Liu, Kaicheng Yang, Xueyu Mao, Min Chu, Yong Wang, Jing Zhao   +7 more
wiley   +1 more source

Intranasal Galanin (1–15) modulates alcohol self-administration and depressive-like behavior in rats and shows a favorable safety profile

Frontiers in Pharmacology
IntroductionGalanin is a neuropeptide in the central nervous system that regulates mood and alcohol consumption. Its N-terminal fragment, Galanin (1–15) [GAL (1–15)], has demonstrated specific behavioral effects, enhancing the efficacy of selective ...
Noelia Cantero-García, Antonio Flores-Burgess, Marta Flores-Gómez, Juan Pedro Pineda-Gómez, Maria C. Ramos, Caridad Diaz, Carmelo Millón, Zaida Díaz-Cabiale   +7 more
doaj   +1 more source

Nasal transmission of equine parvovirus hepatitis

Journal of Veterinary Internal Medicine, 2022
Background Equine parvovirus hepatitis (EqPV‐H) is highly prevalent and causes subclinical to fatal hepatitis, which can occur in outbreaks. Whereas iatrogenic transmission is well documented, the mode of horizontal transmission is not known.
Joy E. Tomlinson, Gerlinde R. Van de Walle   +1 more
doaj   +1 more source

Redefining Therapies for Drug‐Resistant Tuberculosis: Synergistic Effects of Antimicrobial Peptides, Nanotechnology, and Computational Design

Advanced Healthcare Materials, EarlyView.
Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.
Christian S. Carnero Canales, Jessica Ingrid Marquez Cazorla, Renzo Marianito Marquez Cazorla, Aline Martins dos Santos, Jonatas Lobato Duarte, Letícia Oliveira Catarin Nunes, Túlio Custódio Reis, Lara Cerazi Salvador, Norival Alves Santos‐Filho, Rafael Miguel Sábio, Hélder A. Santos, Fernando Rogério Pavan   +11 more
wiley   +1 more source

Intranasal administration of a recombinant RBD vaccine induced protective immunity against SARS-CoV-2 in mouse

Vaccine, 2021
The emergence of the global Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) pandemic underscores the importance of the rapid development of a non-invasive vaccine that can be easily administered.
Yingying Du, Yuhua Xu, Jin Feng, Longbo Hu, Yanan Zhang, Bo Zhang, Weili Guo, Runming Mai, Liyun Chen, Jianmin Fang, Hui Zhang, T. Peng   +11 more
semanticscholar   +1 more source