Potential of Nanoparticle-Based Phototherapies for Future Treatment of Uveal Melanoma. [PDF]
Adv Sci (Weinh)This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Lambert E +8 more
europepmc +2 more sources
Allele-Specific GNAQ Q209 Mutations Reveal Context-Dependent Oncogenic Programs in Uveal Melanoma. [PDF]
Pigment Cell Melanoma ResUsing matched immune‐competent, multistep uveal melanoma models, we show that GNAQ Q209L and Q209R mutations are not functionally equivalent. Q209L drives faster in vivo progression but reduces in vitro proliferation and migration, whereas Q209R promotes greater in vitro fitness and preferential FAK‐YAP activation, revealing an allele‐dependent ...
Jarajapu V +5 more
europepmc +2 more sources
Elevated VEGF-A & PLGF concentration in aqueous humor of patients with uveal melanoma following Iodine-125 plaque radiotherapy [PDF]
International Journal of Ophthalmology, 2020 AIM: To measure the concentration of vascular endothelial growth factor-A (VEGF-A), and placental growth factor (PLGF) in aqueous humor of uveal melanoma patients before and after Iodine-125 plaque therapy (IPT), determine the postoperative fluctuation ...
Meng-Xi Chen +4 more
doaj +1 more source
Endogenous bacterial endophthalmitis masquerading as an intraocular tumor [PDF]
Saudi Journal of Ophthalmology, 2016 Giovanni Staurenghi +2 more
exaly +2 more sources
miRNA-145/miRNA-205 inhibits proliferation and invasion of uveal melanoma cells by targeting NPR1/CDC42 [PDF]
International Journal of Ophthalmology, 2020 AIM: To investigate the role of microRNA-145 (miRNA-145) and microRNA-205 (miRNA-205) in proliferation and invasion of uveal melanoma (UM) cells. METHODS: The expression level of miRNA-145 and miRNA-205 from samples of UM patients were determined by ...
Yang Li +3 more
doaj +1 more source
Retinal nerve fiber layer thickness and retinal vascular caliber alterations in coal miners in northern China: a community-based observational study [PDF]
International Journal of Ophthalmology, 2022 AIM: To evaluate retinal nerve fiber layer thickness and retinal vascular caliber alterations in coal mine workers. METHODS: The community-based observational cross-sectional study included 4004 participants of a sub-population of the Kailuan Study.
Jing-Yan Yang +7 more
doaj +1 more source
Influencing factors for peripheral and posterior lesions in mild non-proliferative diabetic retinopathy—the Kailuan Eye Study [PDF]
International Journal of Ophthalmology, 2020 AIM: To explore the influencing factors of diabetes type 2 patients with mild non-proliferative diabetic retinopathy (NPDR) in the Kailuan area of Tangshan, Hebei Province, China.
Mo-Chi Yang +10 more
doaj +1 more source
Role of microRNA-21 in uveal melanoma cell invasion and metastasis by regulating p53 and its downstream protein [PDF]
International Journal of Ophthalmology, 2018 AIM: To reveal the insight mechanism of liver metastasis in uveal melanoma, we investigated cell functions of microRNA-21 in three different uveal melanoma cell lines and analyze the relationship of target gene p53 and its downstream targets.
Ying-Chih Wang +3 more
doaj +1 more source
Beta zone parapapillary atrophy in elderly Chinese
BMC Ophthalmology, 2022 Purpose Assess the beta zone parapapillary atrophy in elderly Chinese. Patients and methods The Beijing Eye Study 2011 is a population-based cross-sectional study, which includes 3468 patients with the average age of 64.5 ± 9.8 years.
Ling Xiao Zhou +5 more
doaj +1 more source
Chinese Medical Journal, 2020 . Background. Uveal melanoma (UM) is the most common primary intraocular malignancy in adults. It has been demonstrated that microRNA-145 (miR-145) is correlated with the progression of various cancers by regulating the expression of multiple target ...
Jing-Yan Yang +6 more
doaj +1 more source