Results 91 to 100 of about 1,264,565 (184)

Functional validation of driver mutation‐specific uveal melanoma biomarkers: role of COL9A3 in cancer cell plasticity

The Journal of Pathology, Volume 270, Issue 2, Page 226-240, October 2026.
Abstract Uveal melanoma (UM) is a deadly ocular malignancy with well‐described genetic alterations that predict disease outcome. However, our current understanding of the biological underpinnings of high‐risk uveal melanoma progression remains relatively limited. Using RNA expression profiles from 250 patients with UM, we identified 12 novel biomarkers
QCC van den Bosch, RM Verdijk, H Fadlelseed, TPP van den Bosch, S Owens, S Kennedy, E Kilic, E Brosens   +7 more
wiley   +1 more source

Intracranial transplantation of the tumor induced by adenovirus type 12 in Syrian hamster--an experimental brain tumor model [PDF]

, 1971
A method of intracranial transplantation of the tumor induced by adenovirus type 12 in syrian hamster has been described. The incidence of intracranial tumor development was 86 (90.5 %) out of 95 animals and the average survival time and tumor size at ...
Tabuchi, Kazuo
core   +1 more source

Complete Regression of bilateral Choroidal Metastases secondary to a Cutaneous Melanoma under Immunotherapy

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Yenny Angela, Alena Riesmeier, Ralf Gutzmer, Miltiadis Fiorentzis, Nikolaos E. Bechrakis, Carsten Framme, Ekaterina Sokolenko   +6 more
wiley   +1 more source

DNA Origami Uptake in Y‐79 Retinoblastoma Cells Driven by Oligolysine Coating

Small Structures, Volume 7, Issue 10, October 2026.
We show that polymeric coating can enable DNA origami nanoparticle internalization into ocular retinoblastoma cells. Not only are the coated nanoparticles well‐tolerable to the cells, but they also remain mobile in the vitreous of a porcine ex vivo model.
Anna Klose, Zahra Gounani, Sergei Raik, Artturi Koivuniemi, Sonja Korhonen, Mika Reinisalo, Tatu Lajunen, Veikko Linko, Timo Laaksonen   +8 more
wiley   +1 more source

Nonlinear simulation of the effect of microenvironment on tumor growth [PDF]

, 2007
In this paper, we present and investigate a model for solid tumor growth that incorporates features of the tumor microenvironment. Using analysis and nonlinear numerical simulations, we explore the effects of the interaction between the genetic ...
Macklin, Paul, Lowengrub, John
core   +1 more source

Feasibility of multiomics tumor profiling for guiding treatment of melanoma

There is limited evidence supporting the feasibility of using omics and functional technologies to inform treatment decisions. Here we present results from a cohort of 116 melanoma patients in the prospective, multicentric observational Tumor Profiler ...
Frei, Anja, Irmisch, Anja, Baciu-Drăgan, Monica-Andreea, Ring, Alexander, Tusup, Marina, Schuerch, Manuel, Beisel, Christian, Lehmann, Kjong-Van, Gosztonyi, Benedict, Rätsch, Gunnar, Chicherova, Natalia, Bertolini, Anne, Heinzelmann, Viola, Theocharides, Alexandre, Rahimzadeh, Parisa, Bonilla, Ximena, Chevrier, Stéphane, Pelkmans, Lucas, Maass, Gerd, Lischetti, Ulrike, Dummer, Reinhard, Sivapatham, Sujana, Wicki, Andreas, Boos, Laura Amanda, Mena, Julien, Gut, Gabriele, Wollscheid, Bernd, Nowak, Marta, Toussaint, Nora Christina, Milani, Emanuela S., del Castillo, Jacobo Sarabia, Beerenwinkel, Niko, Prummer, Michael, Snijder, Berend, Goetze, Sandra, Moch, Holger, Ferreira, Pedro, Sobottka, Bettina, Casanova, Ruben, Jacobs, Alice K., Koelzer, Viktor H., Kuipers, Jack, Bacac, Marina, Miglino, Nicola, Jacob, Francis, Aebersold, Ruedi, Weller, Michael, Wegmann, Rebekka, Manz, Markus G., Mehra, Tarun, Esposito, Cinzia, Bodenmiller, Bernd, Singer, Franziska, Levesque, Mitchell P., Yu, Shuqing   +54 more
core   +1 more source

Lens-induced myopization and body weight in young guinea pigs

BMC Ophthalmology
Background To investigate the relationship between body weight and Axial length in guinea pigs. Methods Forty pigmented guinea pigs were randomly divided into two groups, namely control group and negative lens-induced myopization (LIM) group.
Hao-Tian Wu, Xu-Han Shi, Li Dong, Rui-Heng Zhang, Yi-Tong Li, Wen-Bin Wei   +5 more
doaj   +1 more source

Pigmented corneal striae: An overlooked clinical sign associated with equine anterior uveal melanocytic neoplasia

Equine Veterinary Education, EarlyView.
R. J. McMullen Jr
wiley   +1 more source

Immunobiology of IL-17A in human colorectal cancer [PDF]

, 2015
During the last decade tumor infiltration by immune cells has been recognized as a key factor determining clinical outcome. Whereas the presence within tumor tissues of defined lymphocytic populations, including cytotoxic CD8+ T cells and IFN-gamma ...
Amicarella, Francesca
core   +1 more source

Spatially resolved transcriptomics reveals gene expression characteristics in uveal melanoma

Holistic Integrative Oncology
Purpose Uveal melanoma (UM) is the most common intraocular malignancy in adults. Previous studies have examined the intra-tumoral heterogeneity. However, the spatial distribution of tumor cells within the tumor microenvironment and its relationship with ...
Jing-Ying Xiu, Yu-Ning Chen, Ya-Li Mao, Jing-Ting Luo, Hao-Wen Li, Yang Li, Wen-Bin Wei   +6 more
doaj   +1 more source