Results 51 to 60 of about 1,264,565 (184)

Engineering Biology Beyond Single Genes: Advances and Challenges in Multiplex Genome Editing

Animal Research and One Health, EarlyView.
Multiplex genome editing is transforming genome engineering from single‐gene perturbation to network‐level control, yet its broader application remains limited by challenges in gRNA array engineering, delivery technologies, and safety management. Emerging AI‐driven approaches are accelerating guide RNA design and CRISPR effector optimization for ...
Linli Wang, Yongbin Liu, Hongbing Han
wiley   +1 more source

Multi-omics data reveal B cell regulated immune heterogeneity of MIF signaling pathway in uveal melanoma

Cancer Cell International
Background Tebentafusp, a T-cell receptor (TCR)-based therapeutic agent, has emerged as a groundbreaking treatment for uveal melanoma (UM), particularly in cases of metastatic UM.
He-Yan Li, Li Dong, Yue-Ming Liu, Wen-Bin Wei   +3 more
doaj   +1 more source

Artificial Intelligence in Ophthalmology: From Methodological Advances to Clinical Translation and Future Directions

Eye &ENT Research, EarlyView.
ABSTRACT Artificial intelligence (AI) is reshaping ophthalmology from task‐specific image analysis toward multimodal, longitudinal, and clinically integrated decision support. This narrative review summarizes the methodological evolution of ophthalmic AI, including traditional machine learning, task‐specific deep learning, self‐supervised learning ...
Yuxin Liu, Hanruo Liu
wiley   +1 more source

From nature to nanoscale: advances, challenges, and preclinical translation of nanofiber drug delivery systems containing plant‐derived active ingredients

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Since the early 1960s, nanotechnology has been a critical area of science, allowing for the development of sophisticated nanomaterials. Nanofibers, one of the most widely used nanotechnological drug delivery systems, have emerged as a highly versatile platform within modern pharmaceutical sciences.
Heybet Kerem Polat, Yasin Turanlı, Nihat Kurt, Sefa Gözcü, Emre Tunçel, Hilal Bacanak, Eren Aytekin, Sedat Ünal   +7 more
wiley   +1 more source

Influence of CD8+ T regulatory Cells on Intraocular Tumor Development [PDF]

, 2012
The interior of the eye, or uvea, is a site of immune privilege where certain immune responses are attenuated or completely excluded to protect non regenerating tissues essential for vision.
Dana Michelle Previte, Dana M. Previte, Kyle C McKenna, Kyle C. McKenna   +3 more
core   +1 more source

Conditional reprogramming in eyelid tumors: bridging the model gap in meibomian gland carcinoma

Clinical Cancer Bulletin
Eyelid tumors, particularly sebaceous carcinoma and meibomian gland carcinoma (MGC), are rare but highly aggressive malignancies characterized by diagnostic difficulty, early dissemination, and limited therapeutic options. Progress in understanding their
Shiqi Hui, Dongmei Li
doaj   +1 more source

A novel CREBBP mutation and its phenotype in a case of Rubinstein–Taybi syndrome

BMC Medical Genomics, 2022
Background This study was to report a novel CREBBP mutation and phenotype in a child with Rubinstein–Taybi syndrome. Methods Case report of a 9-year-old boy. Results We described the patient’s clinical manifestations in detail, and found that in addition
Qian Wang, Cong Wang, Wen Bin Wei, Wei Ning Rong, Xiang Yu Shi   +4 more
doaj   +1 more source

Nonthermal plasma approaches for combating implant‐associated infections: A compendious review

VIEW, EarlyView.
Implant‐associated infections pose serious clinical challenges. Non‐thermal plasma (NTP) modifications overcome this bottleneck in distinct ways relative to traditional sterilization methods. Gas‐phase plasmas generate highly energetic species, UV radiation and reactive oxygen/nitrogen species (RONS), which alter the implant surface properties.
A. M. Trimukhe, Satish Rojekar, Amol Gholap, K. Navaneetha Pandiyaraj, Mukesh Patekar, Claudia Riccardi, R. R. Deshmukh, Tomáš Kovářík, Kalim Deshmukh   +8 more
wiley   +1 more source

Retinal photograph-based deep learning system for detection of hyperthyroidism: a multicenter, diagnostic study

Journal of Big Data, 2023
Background Screening for hyperthyroidism using gold-standard diagnostic criteria in the general population is not cost-effective, leading to a relatively high rate of undiagnosed and untreated patients. This study aimed to establish a deep learning-based
Li Dong, Lie Ju, Shiqi Hui, Lihua Luo, Xue Jiang, Zihan Nie, Ruiheng Zhang, Wenda Zhou, Heyan Li, Jost B. Jonas, Xin Wang, Xin Zhao, Chao He, Yuzhong Chen, Zhaohui Wang, Jianxiong Gao, Zongyuan Ge, Wenbin Wei, Dongmei Li   +18 more
doaj   +1 more source

Recent progress on the development of hydrogel‐based microneedles for transdermal drug delivery

VIEW, EarlyView.
This study provides a comprehensive and up‐to‐date analysis of recent progress in HMN technology, covering fundamental transdermal delivery mechanisms and design principles, biomaterials used in HMN fabrication, drug loading and release strategies, and emerging therapeutic applications.
Mohammad Muhtasim Ittisaf, Salman Farsi Taharat, Md. Sadek Miah, Hasan Tasnim Salehin, M. Azam Ali, Shoeb Ahmed   +5 more
wiley   +1 more source