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Detection of Carotid Artery Stenosis with Intraplaque Hemorrhage and Neovascularization Using a Scanning Interferometer

Nano Letters, 2021
Carotid artery stenosis (CAS) is a major cause of stroke or transient ischemic attack (TIA, mini-stroke) in the United States. Carotid endarterectomy (CEA), a surgical procedure, is used to treat CAS. According to the American Heart Association, 1 out of 5 patients underwent CEA inappropriately, which was most commonly due to apparent overestimation of
Raiyan Tripti Zaman   +3 more
openaire   +2 more sources

Mathematical modeling of atherosclerotic plaque destabilization: Role of neovascularization and intraplaque hemorrhage

Journal of Theoretical Biology, 2018
Observational studies have identified angiogenesis from the adventitial vasa vasorum and intraplaque hemorrhage (IPH) as critical factors in atherosclerotic plaque progression and destabilization. Here we propose a mathematical model incorporating intraplaque neovascularization and hemodynamic calculation with plaque destabilization for the ...
Guo, Muyi   +3 more
openaire   +3 more sources

Quantitative Contrast-Enhanced Ultrasound of Intraplaque Neovascularization in Patients with Carotid Atherosclerosis

Ultraschall in der Medizin - European Journal of Ultrasound, 2014
Intraplaque neovascularization (IPN) is an increasingly studied marker of the vulnerable atherosclerotic plaque, and contrast-enhanced ultrasound (CEUS) is an in vivo imaging technique for the assessment of IPN. The purpose of this study was to test novel quantification methods for the detection of carotid IPN using CEUS.25 patients with established ...
Oord, Stijn   +12 more
openaire   +2 more sources

Effect of pharmacologic anti-atherosclerotic therapy on carotid intraplaque neovascularization: A systematic review

Journal of Clinical Lipidology, 2023
Intraplaque neovascularization (IPN), a key feature of vulnerable carotid plaque, is associated with adverse cardiovascular (CV) events. Statin therapy has been shown to diminish and stabilize atherosclerotic plaque, but its effect on IPN is uncertain.
Edward Cui   +6 more
openaire   +3 more sources

Carotid Intraplaque Neovascularization Predicts Ischemic Stroke Recurrence in Patients with Carotid Atherosclerosis

Gerontology, 2021
<b><i>Introduction:</i></b> This study aimed to examine whether intraplaque neovascularization (IPN) of carotid plaques, as characterized by contrast-enhanced ultrasound (CEUS), is associated with ischemic stroke recurrence in patients with carotid atherosclerosis.
Yan, Song   +6 more
openaire   +2 more sources

Neovascularization as a Leading Mechanism of Intraplaque Hemorrhage and Carotid Plaque Destabilization: A Narrative Review

Current Vascular Pharmacology
: Intraplaque neovascularization (IPN) is considered a leading mechanism causing carotid plaque destabilization. We provide an objective and comprehensive summary of the biology, imaging techniques, and treatment options related to carotid IPN. Plaque neovascularization has been reported to originate mainly from the adventitial vasa vasorum as a ...
Arkadiusz Jawień, Arkadiusz Migdalski
exaly   +3 more sources

Impact of gender on the density of intraplaque neovascularization: A quantitative contrast-enhanced ultrasound study

Atherosclerosis, 2014
Atherosclerosis is the main underlying cause of the majority of cardiovascular events. Although cardiovascular diseases (CVD) are a major challenge in both males and females, gender specific differences in the prevalence of CVD have been observed. This may indicate that there are differences in the development of atherosclerosis between males and ...
Stijn C.H. van den Oord   +7 more
openaire   +3 more sources

Biochemical and clinical correlation of intraplaque neovascularization using contrast-enhanced ultrasound of the carotid artery

Atherosclerosis, 2014
Several biomarkers reflecting inflammatory or proteolytic activity have been known to represent plaque vulnerability. Moreover, a recent study confirmed that contrast-enhanced ultrasound (CEUS) can visualize intraplaque neovascularization (IPN) and demonstrate plaque vulnerability.
Jin-Bae Kim   +2 more
exaly   +3 more sources

Evaluation of Intraplaque Neovascularization Using Superb Microvascular Imaging and Contrast-Enhanced Ultrasonography

Journal of Stroke and Cerebrovascular Diseases, 2018
Several studies have shown a linkage between intraplaque neovascularization (IPN) and plaque instability. Although contrast-enhanced ultrasonography (CEUS) may help visualize IPN in the carotid artery, its benefits are limited in Japan, where there is no health insurance coverage for contrast agents in medical imaging. Superb microvascular imaging (SMI)
Kazumasa Oura   +3 more
openaire   +2 more sources

New quantification methods for carotid intraplaque neovascularization in contrast enhanced ultrasound

2013 IEEE International Ultrasonics Symposium (IUS), 2013
Carotid intraplaque neovascularization (IPN) has been associated with progressive atherosclerotic disease and plaque vulnerability. Therefore, its accurate quantification might allow early detection of plaque vulnerability. Contrast enhanced ultrasound (CEUS) can detect these small microvessels.
Akkus, Zeynettin   +7 more
openaire   +1 more source

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