Results 151 to 160 of about 58,052 (292)

Cellular Adaptation to Mechanical Stress Emerges via Cell Shrinkage Triggered by Nonlinear Calcium Elevation

open access: yesAdvanced Science, Volume 12, Issue 38, October 13, 2025.
Here, a decision‐making mechanism underlying mechanical adaptation is demonstrated. This study demonstrates that cellular adaptation to mechanical stress can be induced by applying low‐amplitude stretch to cells. When the stretch reaches a critical amplitude threshold, it triggers Ca2⁺‐dependent positive feedback, which induces cholesterol efflux and ...
Zhengyan Wang   +21 more
wiley   +1 more source

Endothelial‐Derived CCL7 Promotes Macrophage Polarization and Aggravates Septic Acute Lung Injury via CCR1‐Mediated STAT1 Succinylation

open access: yesAdvanced Science, Volume 12, Issue 38, October 13, 2025.
During sepsis, pulmonary vascular endothelial cells secrete chemokine CCL7, which plays a pivotal role in facilitating the infiltration of C‐C motif chemokine receptor 1‐positive (CCR1+) macrophages into lung tissue. Activation of the CCL7–CCR1 axis enhances the succinylation of STAT1 mediated by KAT2A, thereby driving metabolic reprogramming and ...
Xue Li   +5 more
wiley   +1 more source

Divergent Delivery and Expression Kinetics of Lipid and Polymeric Nanoparticles across mRNA Modalities

open access: yesAdvanced Science, Volume 12, Issue 38, October 13, 2025.
Self‐amplifying (saRNA), linear (linRNA), and circular (circRNA) mRNAs are compared under standardized conditions using lipid nanoparticles (LNPs) and pABOL polymer. saRNA achieved superior expression, while linRNA and circRNA performance varied based on untranslated region elements and delivery method.
Irafasha C. Casmil   +12 more
wiley   +1 more source

Natural Flavonoid Nobiletin Attenuates Allergic Asthma via Suppression of STAT3/PI3K‐AKT and Neutrophil Extracellular Traps

open access: yesFood Science &Nutrition, Volume 13, Issue 10, October 2025.
This study demonstrates that the natural flavonoid nobiletin alleviates allergic asthma by suppressing STAT3/PI3K‐AKT signaling pathways and neutrophil extracellular trap formation. ABSTRACT Allergic asthma is classically defined by eosinophilic inflammation and Th2 immune responses. However, neutrophils are increasingly recognized as key contributors,
Wen He   +5 more
wiley   +1 more source

Design Strategies for Novel Lipid Nanoparticle for mRNA Vaccine and Therapeutics: Current Understandings and Future Perspectives

open access: yesMedComm, Volume 6, Issue 10, October 2025.
This review summarizes strategies to optimize lipid nanoparticles (LNPs) for improved targeting, endosomal escape, and safety. It highlights mRNA design, alternative delivery systems, and recent therapeutic advances across infectious diseases, cancer, and drug applications.
Xiaochi Li   +7 more
wiley   +1 more source

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