Results 51 to 60 of about 39,887 (243)

Perivascular Matrix Densification Dysregulates Angiogenesis and Activates Pro‐Inflammatory Endothelial Cells

Advanced Science, EarlyView.
Perivascular matrix densification promotes the emergence of aberrant endothelial tip cells (ATECs) that invade and persist within fibrotic microenvironments. Using in vivo lineage tracing and a human microvessel model, this study shows that fibrous matrix cues destabilize VE‐cadherin–mediated junctions to gate TGF‐β signaling, inducing a pro ...
Jingyi Xia, William Y. Wang, Kyle A. Jacobs, Kairav Maniar, Daphne Lin, Evan H. Jarman, Daniel L. Matera, Kristen Loesel, Christopher D. Davidson, Harrison L. Hiraki, Xiaotian Tan, Eve H. Shikanov, Robert N. Kent, Carole Parent, Xudong Fan, Ariella Shikanov, Matthew L. Kutys, Brendon M. Baker   +17 more
wiley   +1 more source

Biodistribution and respiratory toxicity of chloromethylisothiazolinone/methylisothiazolinone following intranasal and intratracheal administration

, 2022
A variety of isothiazolinone-containing small molecules have been registered and used as chemical additives in many household products. However, their biodistribution and potential harmful effects on human health, especially respiratory effects, were not
Seung-Hun Ryu, Kyuhong Lee, Hyunil Shin, Jongho Jeon, Mi-Kyung Song, Young-Hee Kim, Yong-Wook Baek, Dong Im Kim, Sung-Hoon Yoon, Jung Eun Park   +9 more
core   +1 more source

Scalable Engineering of Bio‐Manufactured Extracellular Vesicles for Selective Delivery in Ovarian Cancer Patient‐Derived Models

Advanced Science, EarlyView.
Engineered extracellular vesicles displaying Ephrin‐B2 selectively target Ephrin‐B4–expressing ovarian cancer cells, enabling precise delivery in patient‐derived models. This scalable bio‐manufacturing platform reveals a versatile strategy to exploit Ephrin signaling for highly specific therapeutic payload delivery and motivates exploration of tailored
Nihar Godbole, Andrew Lai, Alexander Quinn, Marianne Gillard, Dominic Guanzon, Katherin Scholz‐Romero, Alexis Salas‐Burgos, Bastián Lillo Dapremont, Rohan Lourie, Naven Chetty, Richard Lobb, Kate Beecher, Amy E. McCart Reed, Kaltin Ferguson, Biao Sun, Yaowu He, John D. Hooper, Carlos Salomon   +17 more
wiley   +1 more source

Intratracheal administration of glucocorticoids using surfactant as a vehicle

, 2002
The definitive version is available at www.blackwell-synergy.com1. Glucocorticoids are an effective treatment in the amelioration of chronic lung disease in neonates.
Vink, R., Whitehall, John, Davidson, Kate, Patole, Sanjay K., Carstairs, Jill R., Davidson, K., Robert Vink, Alan J Nimmo, John Whitehall, Kate Davidson, Vink, Robert, Carstairs, J., Whitehall, J., Nimmo, A., Patole, S., Nimmo, Alan, Jill R Carstairs, Sanjay K Patole   +17 more
core   +1 more source

Comparison of dental force applied during endotracheal intubation with hyper-angulated and macintosh-type video laryngoscopy blades used by emergency medicine trainees: A randomized cross-over manikin study

Turkish Journal of Emergency Medicine
OBJECTIVES: This study aimed to compare the effects of Macintosh-type and hyperangulated video laryngoscopy (VL) blades on dental force during endotracheal intubation (ETI) using Glidescope and McGrath VL devices.
Ali Rıza Karabacak, İbrahim Ulaş Özturan, Ömer Faruk Şefoğlu, Nurettin Özgür Doğan, Elif Yaka, Serkan Yılmaz, Murat Pekdemir   +6 more
doaj   +1 more source

Macrophage‐to‐Myofibroblast Transdifferentiation Contributes to Pulmonary Fibrosis via the MERTK‐SPP1‐SRC‐TKS5 Signaling Axis

Advanced Science, EarlyView.
MERTK is upregulated in fibrotic macrophages and regulates the expression and activity of SRC and TKS5 through SPP1, mediating transdifferentiation of macrophages‐to‐myofibroblasts (MMT) and promoting pulmonary fibrosis. The figure was created with BioRender.com.
Yungeng Wei, Hua Guo, Xiangsheng Yang, Xiao Xiao Tang   +3 more
wiley   +1 more source

SIRT6‐Mediated Deacetylation of ATF3 Promotes Silica‐Induced Lung Fibrosis by Enhancing its Nuclear Import via Binding to Importin α

Advanced Science, EarlyView.
SIRT6‐mediated ATF3 acetylation drives MGARP transcription and mitochondrial dysfunction in macrophages, promoting macrophage senescence and pulmonary fibrosis. Mechanistically, HSP70/Importin α competitively binds to ATF3, modulating its nuclear translocation.
Demin Cheng, Wenxia Bu, Fengxu Wang, Yueyuan Jin, Rongzhu Liu, Rui Zhao, Xuehai Wang, Mengna Jiang, Jinping Shen, Xinhang Cheng, Zuming Chen, Li Zhu, Jinlong Li, Zhenzhong Ge, Shichen Miao, Haotian Xu, Xiaoyu Zhou, Dongming Wang, Xinyuan Zhao   +18 more
wiley   +1 more source

Effects of intratracheal mesenchymal stromal cell therapy during recovery and resolution after ventilator-induced lung injury

, 2013
Background: Mesenchymal stromal cells (MSCs) have been demonstrated to attenuate acute lung injury when delivered by intravenous or intratracheal routes.
Toole, Daniel O’, Ansari, Bilal, Devaney, James, Curley, Gerard F., Hayes, Mairead, Barry, Frank, O’Brien, Timothy, Laffey, John G., Masterson, Claire, Ryan, Aideen   +9 more
core   +1 more source

Effects of intravenous lignocaine on haemodynamic responses to laryngoscopy and tracheal intubation in adults under general anaesthesia: A systematic review and meta-analysis

Indian Journal of Anaesthesia
Background and Aims: Haemodynamic fluctuations during laryngoscopy and tracheal intubation remain a key concern in anaesthetic practice, with cardiovascular stress responses posing risks of serious complications.
Junjun Qin, Changlin He, Zhengwei Chen, Sijun Yan, Jiasen Ma   +4 more
doaj   +1 more source

The changes of endotracheal tube cuff pressure during manual and intermittent controlling in intensive care units

Iranian Journal of Nursing and Midwifery Research, 2020
Background: Usually, the endotracheal tube cuff pressure is controlled by cuff pressure monitoring. However, the intermittent pilot-manometer connection and disconnection may cause a change in the adjusted pressure.
Roghieh Nazari, Christopher Boyle, Mojgan Panjoo, Mohammad Salehpour-Omran, Hamid Sharif Nia, Ameneh Yaghoobzadeh   +5 more
doaj   +1 more source