Results 61 to 70 of about 39,887 (243)

Hemoglobin's α‐Helix‐to‐β‐Sheet Transition Enables Targeted mRNA Delivery to the Lung

Advanced Science, EarlyView.
Acidic heating converts hemoglobin into β‐sheet‐rich fibrils with positively charged surfaces. These hemoglobin fibrils electrostatically complex IL‐11 scFv mRNA, selectively bind circulating platelets, and hitchhike to the lung, where they are enriched in fibroblasts.
Xihua Liu, Saiya Li, Guodong Wu, Shuangjian Li, Long Shuang Huang, Xiaoyang Li, Yiguo Zhao, Wei Lu, Cuixia Sun, Qin Cao, Yapeng Fang, Yiping Cao   +11 more
wiley   +1 more source

Ramped versus sniffing position for videolaryngoscopy-guided tracheal intubation in adult patients: A systematic review and meta-analysis with trial sequential analysis

Indian Journal of Anaesthesia
Background and Aims: The sniffing position is required for direct laryngoscopy to align the oropharyngeal-laryngeal axis in the line of sight. However, videolaryngoscope (VL)-guided intubation may not need a sniffing position. This meta-analysis compared
Navneh Samagh, Mohammed Ahmed, Kiran Jangra, Jyoti Sharma, Shashank Paliwal   +4 more
doaj   +1 more source

Human Urine Stem Cells Alleviate Pulmonary Fibrosis via Inhibiting Macrophage‐Myofibroblast Transition

Advanced Science, EarlyView.
Therapeutic role and mechanism of human urine stem cells (hUSCs) in pulmonary fibrosis. hUSCs alleviated pulmonary fibrosis by selectively inhibiting macrophage‐myofibroblast transition (MMT) in two ways: on one hand, hUSCs inhibited mitochondrial reactive oxygen species (mtROS) production and apoptosis/senescence of epithelial cells in pulmonary ...
Zhou‐Hang Zhang, Guan‐Lin Guo, Xiao‐Hui Guan, Min Hu, Qi‐Ming Huang, Ding‐Wen Guo, Hao‐Cheng Gu, You‐Qiong Zhuo, Ning Li, Hong‐Bo Xin, Ke‐Yu Deng   +10 more
wiley   +1 more source

Comparison of ILMA Guided Tracheal Intubation in the Lateral Position with the Supine Position

Asian Journal of Medical Sciences, 2013
Background: The ILMA has been established as a valuable airway management device in the supine position, in both elective and emergency situations, for both ventilation and intubation.
Manish Naithani
doaj   +1 more source

Intratracheal Administration of Chloroquine-Loaded Niosomes Minimize Systemic Drug Exposure

Pharmaceutics, 2021
Pulmonary administration provides a useful alternative to oral and invasive routes of administration while enhancing and prolonging the accumulation of drugs into the lungs and reducing systemic drug exposure. In this study, chloroquine, as a model drug,
Hesham A. Saafan, Kamilia M. Ibrahim, Yasmeena Thabet, Sara M. Elbeltagy, Rana A. Eissa, Ashraf H. Ghaleb, Fathy Ibrahim, Mahmoud Elsabahy, Noura G. Eissa   +8 more
doaj   +1 more source

Establishment of a chronic aspiration pneumonia mouse model using oropharyngeal aspiration of food suspension

Animal Models and Experimental Medicine, EarlyView.
Four aspiration methods (UV, IN, IT, and OA) were compared, and OA was identified as the most effective delivery technique. A chronic aspiration pneumonia model was then established through repeated OA of food suspension or gastric contents. Integrated analyses, including micro‐CT, histopathology, cytokine profiling, and RNA sequencing, revealed ...
Qianwen Li, Fansen Lin, Hongzhi Gao, Yun Zhao, Yuqi Liu   +4 more
wiley   +1 more source

SDPR–STK38 axis controls the proliferation–differentiation balance in alveolar type II cells

Animal Models and Experimental Medicine, EarlyView.
The present study identifies SDPR as a pivotal regulator orchestrating the balance between proliferation and differentiation in alveolar type II (AT2) cells. In SDPR+/+ cells, SDPR binds to and inhibits STK38 activity, thereby sustaining GSK‐3β signaling functionality to promote cyclin D1 degradation and maintain cell cycle homeostasis.
Jie Wang, Xuepei Lei, Yiying Huang, Jiaming Tang, Guiying Shi, Hang Li, Lin Bai   +6 more
wiley   +1 more source

Acute hazard assessment of silver nanoparticles following intratracheal instillation, oral and intravenous injection exposures [PDF]

, 2021
With ever-increasing production and use of nanoparticles (NPs), there is a necessity to evaluate the probability of consequential adverse effects in individuals exposed to these particles.
Jacobsen, Nicklas Raun, Jacobsen, Nicklas R, Kermanizadeh, Ali, Mroczko, Agnieszka, Brown, David, Stone, Vicki   +5 more
core   +1 more source

Intratracheal administration of antimicrobial agents in mechanically ventilated adults : an international survey on delivery practices and safety [PDF]

, 2016
BACKGROUND: Intratracheal antibiotic administration is increasingly used for treating respiratory infections. Limited information is available on delivery devices, techniques, and safety.
Felton, Tim; id_orcid, Pereira, Joao Manuel, Solé Lleonart, Candela, Welte, Tobias, Bassetti, Matteo, Roberts J. A., Palmer L. B., Felton, Tim, Rello, Jordi, Welte T., Blot S., Luyt, Charles Eduard, Bassetti M., Rouby, Jean Jacques, Felton T., Poulakou G., Riera J., Pereira J. M., Rouby, Jean-Jacques, Chastre J., Rouby J. -J., Roberts, Jason A, Poulakou, Garyfallia, Sole-Lleonart C., Luyt, Charles-Eduard, Riera, Jordi, Rello J., Palmer, Lucy B, Blot, Stijn, Luyt C. -E., Solé-Lleonart, Candela, Chastre, Jean, Pereira, Joao M, Palmer, Lucy B., Roberts, Jason A.   +34 more
core   +2 more sources

Building an international precision medicine platform trial for the acute respiratory distress syndrome (ARDS): an expert consensus project report

Efficacy and Mechanism Evaluation
Background Almost all large-scale trials of disease-modifying therapeutic agents in critical care have failed to show benefit for patients, which may be explained in part by the clinical and biological heterogeneity inherent in virtually all critical ...
Kiran Reddy, Neil Aggarwal, Narges Alipanah-Lechner, Djillali Annane, David B Antcliffe, Daphne Babalis, J Kenneth Baillie, Abigail Beane, Lieuwe DJ Bos, Aidan Burrell, Carolyn S Calfee, Kiki Cano-Gamez, Victoria R Cornelius, Mary Cross, Emma Davenport, Lorenzo del Sorbo, Laura Esserman, Eddy Fan, Vito Fanelli, Niall D Ferguson, D Clark Files, Christoph Fisser, Shigeki Fujitani, Ewan C Goligher, Anthony C Gordon, Giacomo Grasselli, Fergus Hamilton, Rashan Haniffa, Andrea Haren, Daniel JR Harvey, Leanne M Hays, Anna Heath, Nicholas Heming, Susanne Herold, Tim Hicks, Nao Ichihara, Vinod Jaiswal, Jun Kataoka, Julian C Knight, Patrick R Lawler, Kathleen Liu, John C Marshall, David M Maslove, Michael A Matthay, Daniel F McAuley, Nuala J Meyer, Jonathan A Millar, Holger Müller-Redetzky, Alistair Nichol, John Norrie, Marlies Ostermann, Andrew Owen, Cecilia M O’Kane, Dhruv Parekh, Rachel Phillips, Duncan Richards, Bram Rochwerg, Anthony J Rostron, Hiroki Saito, Romit J Samanta, Vittorio Scaravilli, Wesley Self, Manu Shankar-Hari, A John Simpson, Pratik Sinha, Marry R Smit, Jonathan Stewart, B Taylor Thompson, István Vadász, Ed Waddingham, Steve Webb, Graham Wheeler, D Martin Witzenrath, Mark M Wurfel, Thomas R Martin   +74 more
doaj   +1 more source