Results 1 to 10 of about 668,827 (125)

In Vivo Imaging of Click-Crosslinked Hydrogel Depots Following Intratympanic Injection [PDF]

Materials, 2020
In this study, we developed injectable intratympanic hyaluronic acid (HA) depots for the treatment of hearing loss. We prepared an injectable click-crosslinking formulation by modifying HA with tetrazine (HA-TET) and trans-cyclooctene (HA-TCO), which ...
Mina Park, Moon Suk Kim, Hak Soo Choi
exaly   +3 more sources

Adjunctive Hyperbaric Oxygen Therapy or Intratympanic Steroids in Sudden Sensorineural Hearing Loss? [PDF]

Laryngoscope
Sudden sensorineural hearing loss is traditionally treated with steroids, either orally and/or via intratympanic injections, and hyperbaric oxygen treatment (HBOT) has resurged in popularity as an adjunctive therapy. The study has not found any additional treatment benefit with adjunctive concurrent HBOT; however, HBOT might be of value to patients ...
Spiegel JL, De Biasio MJ, Sampieri G, Ungar OJ, Bajin MD, Lin VYW, Chen JM, Idestrup C, Tarshis J, Le TN.   +9 more
europepmc   +2 more sources

Efficiency of a dexamethasone nanosuspension as an intratympanic injection for acute hearing loss [PDF]

Drug Delivery, 2022
So-Young Jung, Dong-Kee Kim, Subin Kim
exaly   +2 more sources

Luteolin Protects Against Noise-Induced Hearing Loss via Mitigating Oxidative Stress and Apoptosis, With Potential Regulation of the EGR1/SPRY4 Axis. [PDF]

CNS Neurosci Ther
Luteolin attenuates noise‐induced auditory hair cell loss, as well as TBHP‐induced oxidative stress and apoptosis. EGR1 modulates the transcription of SPRY4; the expression levels of both factors are upregulated following TBHP exposure, and this inductive effect is abrogated by luteolin treatment.
Guo JN, Mei HK, Liang R, Ma PW, Wang WL, Chen JW, Wang Z, Yuan H, Lun YQ, Gao W, Lu LJ.   +10 more
europepmc   +2 more sources

Impact of Age and Nerve Impairment Interaction on Bell's Palsy Prognosis

The Laryngoscope, EarlyView.
This study investigated the prognostic impact of the interaction between aging and nerve impairment severity in 181 patients with Bell's palsy. Although age alone was not an independent predictor, the interaction between older age (≥ 65 years) and a Nerve Excitability Test threshold difference (≥ 3.5 mA) significantly increased the risk of incomplete ...
Hiroyuki Yamada, Miyuki Oshita, Takemichi Tanaka, Shota Miyaji, Takuya Kimura, Shinji Iwata, Ryota Takagi, Naohito Hato   +7 more
wiley   +1 more source

Molecular Biomarkers in Meniere's Disease: A Scoping Review of Current Evidence

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective Meniere's disease is a complex chronic inner ear condition that is characterized by vertigo, tinnitus, aural fullness, and progressive hearing loss. Currently, diagnostic strategies remain symptom‐driven, and treatments focus on management of discrete episodes rather than targeting underlying pathophysiology.
Hamza Kamran, Zaharadeen Jimoh, Tariq Issa, Nahla A. Gomaa   +3 more
wiley   +1 more source

Optimizing Hyperbaric Oxygen Therapy for Sudden Hearing Loss

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective To optimize the hyperbaric oxygen therapy protocol for sudden sensorineural hearing loss by identifying the most effective treatment course and analyzing key prognostic factors through a multicenter retrospective cohort study. Study Design Retrospective cohort study.
Yuting Sun, Yu Yang, Zhentao Wang, Hui Zhao, Xiaoli Ge, Shuming Pan   +5 more
wiley   +1 more source

The Relationship Between Blood Lipids, Coagulation Indexes, Blood Homocysteine and Sudden Deafness: A Retrospective Study and Mendelian Randomization Analysis

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Certain blood components, including blood lipids, coagulation parameters, and homocysteine, have been suggested to correlate with the incidence and prognosis of sudden sensorineural hearing loss (SSNHL). However, the nature of these associations remains controversial.
Feng‐Xin Yang, Yu‐Wan Song, Yan Wang, Kun Zhao, Hu‐Hui‐Fen He, Jing‐Jing Qiu, Da‐Wei Liu, Bo Li, Yan Sun   +8 more
wiley   +1 more source

Characterization of the Middle Ear Microbiome in Meniere's Disease by 16S rRNA Gene Sequencing Compared to Chronic Suppurative Otitis Media

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective To investigate the middle ear microbiome in Meniere's disease (MD) patients. Methods Middle ear smears from 10 MD patients (ME group) and 10 chronic suppurative otitis patients (OE group) were collected during surgery and processed via 16S rRNA gene sequencing.
Yu‐Ting Tao, Lin Wang, Hong‐wei Zheng, Li‐Sheng Yu   +3 more
wiley   +1 more source

Ménière's Disease: A Tri‐Decade Scoping Review of Treatment Trends and Evidence Quality

The Laryngoscope, Volume 136, Issue 10, Page 4482-4488, October 2026.
This tri‐decade scoping review of Ménière's disease literature reveals a significant increase in high‐level evidence and a clinical pivot toward hearing‐preserving interventions, such as intratympanic steroids and cochlear implants. However, a significant quality paradox has emerged, where adherence to standardized AAO‐HNS reporting and diagnostic ...
Ofir Zavdy, Teeraya Piyajarawong, Seamus Boyle, Ross O'Shea, John Rutka   +4 more
wiley   +1 more source