Evaluation of the acceptability of intravaginal prasterone ovule administration using an applicator
Gynecological Endocrinology, 2016 The objective of the study is to evaluate the acceptability of the intravaginal administration of ovules/suppositories of DHEA (dehydroepiandrosterone, prasterone) for the treatment of vulvovaginal atrophy (VVA) in women with moderate to severe dyspareunia who were administered daily for 12 weeks intravaginal 0.50% (6.5 mg) DHEA or placebo.
Marlene, Montesino +10 more
openaire +3 more sources
Intravaginal administration of progesterone: the first uterine pass effect
JBRA Assisted Reproduction, 2001 M. Cavagna, DP Pereira
openalex +2 more sources
Development of a Vaginal Extracellular Matrix Hydrogel for Combating Genitourinary Syndrome of Menopause. [PDF]
Adv MaterIn this study, a vaginal specific ECM hydrogel (vECM) is developed, optimized for intravaginal topical administration, and evaluated for mitigatation of vaginal atrophy associated with menopause. When applied in a rat model of menopause, vECM improves vaginal epithelial thickness and stem cell phenotype, and despite topical application, vECM also ...
Zelus EI +6 more
europepmc +2 more sources
Intra-vaginal gemcitabine-hybrid nanoparticles for effective cervical cancer treatment
OpenNano, 2022 Aim: This study aims to develop and evaluate hybrid nanoparticles for the effective intravaginal delivery of the anticancer gemcitabine in cervical cancer rat model.
Mona Elhabak +2 more
doaj +1 more source
Drug Delivery, 2023 Polymeric drug-releasing vaginal rings are useful for both local and systemic administration of drugs via the intravaginal route. Typically, they provide continuous sustained or controlled release of drug(s) over extended time periods, thereby avoiding ...
Willem de Laat +8 more
doaj +1 more source
Randomized trial of the efficacy of intravaginal ulinastatin administration for the prevention of preterm birth in women with a singleton pregnancy and both cervical shortening and inflammation of lower genital tract [PDF]
The journal of obstetrics and gynaecology research, 2018 To assess the preventive effect on preterm birth of intravaginal ulinastatin (urinary trypsin inhibitor; UTI) administration during the mid‐trimester in women with singleton pregnancy and both cervical shortening and lower genital infections.
Katsufumi Otsuki +8 more
openalex +2 more sources
The Journal of Reproduction and Development, 2023 Secretion of pulsatile gonadotropin-releasing hormone (GnRH) is essential for reproduction. Kisspeptin neurons in the arcuate nucleus (ARC), which coexpress neurokinin B (NKB) and its receptor (NK3R), are believed to be components of the GnRH pulse ...
Takashi YAMAMURA +2 more
doaj +1 more source
Myo-inositol in the treatment of male factor infertility [PDF]
Гинекология, 2022 About 187 million couples worldwide suffer from infertility, with the male factor being diagnosed in 2070% of cases. The main cause of idiopathic infertility has been recognized as the adverse effects of reactive oxygen species.
Evgenia V. Shikh +3 more
doaj +1 more source
Intravaginal Administration of Sildenafil Citrate Increases Blood Flow in the Bovine Uterus [PDF]
, 2015 The aim of the study was to evaluate the influence of sildenafil citrate administrated intravaginaly on the blood flow in the bovine uterus during dioestrus. Uterine blood flow was examined in six healthy adult cows.
Michał Dzięcioł +4 more
openalex +2 more sources
Comparison of Two Different Intervals of Misoprostol Administration in Second Trimester Abortions
Journal of Family and Reproductive Health, 2023 Objective: Comparison of two different intervals of misoprostol administration after mifepristone in second trimester abortions. Materials and methods: This 12-month prospective study was conducted at a tertiary care facility.
Anjali Gupta +6 more
doaj +1 more source