Clinical efficacy of intravaginal recombinant lysostaphin administration on endometritis in sows [PDF]
Veterinary Medicine and Science, 2021 Recombinant lysostaphin has been used for the treatment of cow endometritis and mastitis in China. To our knowledge, no scientific effort has been made to evaluate the efficacy of lysostaphin in sows with clinical endometritis.
Guizi Ye +8 more
doaj +3 more sources
Intravaginal Delivery of Oxybutynin: An Alternative Administration Route to Improve its Pharmacokinetic and Pharmacodynamic Effects [PDF]
European Urology Open ScienceBackground and objective: While oxybutynin is the most efficacious oral antimuscarinic treatment to reduce incontinence episodes in patients with an overactive bladder, oxybutynin is often discontinued due to significant side effects.
Sophie I. Peltenburg +12 more
doaj +2 more sources
Intravaginal administration of estradiol benzoate capsule for estrus synchronization in goats
The Journal of Reproduction and Development, 2021 Estrus synchronization requires multiple treatments of hormonal drugs, requiring considerable time and cost. The aim of the present study was to develop an estrus synchronization protocol using intravaginal administration of estradiol benzoate (EB ...
Sayaka MATSUMOTO +2 more
doaj +4 more sources
Introducing personalized patient care in overactive bladder management using the MedRing OAB system for intravaginal oxybutynin administration [PDF]
Drug DeliveryAlthough numerous drugs have been developed for intravaginal administration, the implementation of personalized intravaginal treatment options is limited.
S. I. Peltenburg +6 more
doaj +2 more sources
Sperm-disrupting activity of a root bark fraction of Flueggea virosa (Roxb. ex willd.) royle uncovered using LC-MS/MS profiling and functional evaluation [PDF]
Frontiers in PharmacologyIntroductionWhile Flueggea virosa (Roxb. Ex Willd.) Royle root bark is traditionally used in several parts of East Africa for fertility regulation, its contraceptive potential has not been systematically investigated.
Kehongo M. Nyanguru +17 more
doaj +2 more sources
Clotrimazole‐loaded PLGA microparticles for local drug delivery to the vagina: Shape does matter [PDF]
Animal Models and Experimental MedicineBackground Intravaginal drug administration is the most promising strategy for treating vaginal infections to protect women's health, such as vulvovaginal candidiasis (VVC). However, conventional vaginal formulations in the clinic face challenges such as
Yanyu Li +8 more
doaj +2 more sources
Intra-vaginal gemcitabine-hybrid nanoparticles for effective cervical cancer treatment
OpenNano, 2022 Aim: This study aims to develop and evaluate hybrid nanoparticles for the effective intravaginal delivery of the anticancer gemcitabine in cervical cancer rat model.
Mona Elhabak +2 more
doaj +1 more source
Drug Delivery, 2023 Polymeric drug-releasing vaginal rings are useful for both local and systemic administration of drugs via the intravaginal route. Typically, they provide continuous sustained or controlled release of drug(s) over extended time periods, thereby avoiding ...
Willem de Laat +8 more
doaj +1 more source
Comparison of Two Different Intervals of Misoprostol Administration in Second Trimester Abortions
Journal of Family and Reproductive Health, 2023 Objective: Comparison of two different intervals of misoprostol administration after mifepristone in second trimester abortions. Materials and methods: This 12-month prospective study was conducted at a tertiary care facility.
Anjali Gupta +6 more
doaj +1 more source
Myo-inositol in the treatment of male factor infertility [PDF]
Гинекология, 2022 About 187 million couples worldwide suffer from infertility, with the male factor being diagnosed in 2070% of cases. The main cause of idiopathic infertility has been recognized as the adverse effects of reactive oxygen species.
Evgenia V. Shikh +3 more
doaj +1 more source