Results 121 to 130 of about 50,715 (282)

Intranasal diamorphine population pharmacokinetics modeling and simulation in pediatric breakthrough pain

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 435-447, March 2025.
Abstract Intranasal diamorphine (IND), approved for managing breakthrough pain in the UK, has been identified as an acceptable alternative offering effective, expedient, and less traumatic analgesia for children. However, the current dose regimen in pediatric populations relies on clinical expertise while the pharmacokinetics properties are poorly ...
Lianjin Cai   +6 more
wiley   +1 more source

Abuse and misuse of antidepressants

open access: yesSubstance Abuse and Rehabilitation, 2014
Elizabeth A Evans, Maria A Sullivan Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA Background: Rates of prescription drug abuse have reached epidemic proportions.
Evans EA, Sullivan MA
doaj  

Biomaterial‐Based Emergency Intervention for Secondary Spinal Cord Injury

open access: yesSmall Science, EarlyView.
Emergency intervention using advanced biomaterials targets key pathological mechanisms to block secondary spinal cord injury (SCI) by inhibiting inflammation, reducing excitotoxicity, restoring the blood−spinal cord barrier, and limiting scar formation, which provides significant neural protection and promotes neural regeneration, offering promising ...
Jincheng Li   +5 more
wiley   +1 more source

Brain‐Targeted Multifunctional Liposomes Reprogram Microglia via Anti‐Inflammatory Signaling and Reactive Oxygen Species Scavenging to Treat Post‐Traumatic Neuroinflammation

open access: yesSmall Structures, EarlyView.
Excessive inflammatory microglial cells in traumatic brain injury (TBI) site is a major driver of postinjury chronic neuroinflammation. A nanointegrative strategy is reported that enables efficient remodeling of TBI‐residing microglial cell fate specification through cooperative inhibition of NF‐κB/MAPK/TLR4 signaling and reactive oxygen species ...
Xuan Wang   +7 more
wiley   +1 more source

EVALUATION OF THE PARTNERSHIP FOR INTERVENTION AND EMPOWERMENT (PIE) PROJECT [PDF]

open access: yes, 2009
HIV/AIDS has become a major public health concern in the United States over the past 35 years and when paired with substance abuse, specifically intravenous drug use, the co-occurrence can have a significant impact on the risk of HIV infection.
Currey, Jillian Melissa
core  

Remimazolam Preserves Oxygen Reserve and Improves Sedation Safety Compared to Propofol in Endoscopic Retrograde Cholangiopancreatography

open access: yesUnited European Gastroenterology Journal, EarlyView.
ABSTRACT Background Remimazolam is a short‐acting benzodiazepine with less cardiorespiratory depression compared with propofol. The Oxygen Reserve Index (ORi) reflects oxygenation status in the mild hyperoxic range and can detect subtle respiratory depression induced by sedatives.
Jee Hoon Kim   +9 more
wiley   +1 more source

Surto de malária induzida entre usuários de drogas injetáveis

open access: yesRevista de Saúde Pública
Em julho de 1990, foi registrado na cidade de Bauru, Estado de São Paulo, Brasil, um surto de malária envolvendo usuários de cocaína injetável. Uma ampla investigação epidemiológica, conduzida de 19 de julho a 13 de setembro, revelou que pelo menos 119 ...
Luiz Carlos Barradas Barata   +2 more
doaj  

An Alternative Public Health Vision for a National Drug Strategy: Treatment Works [PDF]

open access: yes, 1991
This article returns to a war waged virtually throughout this century--a war between the theories of punishment and rehabilitation in curtailing the drug epidemic. Today, the terms of the war are recast as supply-side policies based upon law enforcement;
Gostin, Lawrence O.
core   +1 more source

Tissue engineering for tendon and ligament repair: Insights and advances

open access: yesVIEW, EarlyView.
Tendon and ligament injuries are widespread diseases, leading to severe pain and a consequent reduced mobility. This phenomenon is mainly due to the limited ability to self‐healing of these tissues. Unfortunately, the currently available surgical and rehabilitative treatments suffer frequent complications and incomplete success.
Francesca Romano   +3 more
wiley   +1 more source

Ultrasound-Guided Lateral Femoral Cutaneous Nerve Cryoneurolysis for Analgesia in Patients With Burns. [PDF]

open access: yes, 2020
Autologous skin grafting from the thigh is frequently required for treatment of burns and is associated with intense pain at the donor site. Local anesthetic-based (LA) nerve blocks of the lateral femoral cutaneous nerve (LFCN) have been demonstrated to ...
Fiallo, Alfredo   +6 more
core  

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