Results 111 to 120 of about 946,335 (267)

Peptide‐directed nanovehicles enabling tumor‐selective ROS amplification and antitumor immunity

VIEW, EarlyView.
Cancer cells are vulnerable to oxidative stress, yet exploit immune tolerance to escape destruction. In contrast, their metabolic profile is markedly altered to support rapid proliferation, accompanied by elevated production of reactive oxygen species (ROS).
Manuela Calin, Galyna Bila, Ileana Manduteanu, Rostyslav Bilyy   +3 more
wiley   +1 more source

Protodesnitazene: The identification and tissue distribution of a new nitazene

Journal of Forensic Sciences, EarlyView.
Abstract Multiple new analogues from the 2‐benzyl benzimidazole or “nitazene” class of drugs have emerged on the drug market in recent years. Nitazenes are highly potent μ‐opioid receptor agonists that present a substantial public health concern due to their elevated risk of severe toxicity in overdose and their significant potential for misuse.
Andrew Griffiths, Nathan Milne, Michelle Johnston, Karen Blakey, Rogan Scott   +4 more
wiley   +1 more source

Europe's contribution to the evaluation of the use of systemic antimicrobials in the treatment of periodontitis

Periodontology 2000, EarlyView., 2023
Abstract This narrative review celebrates Europe's contribution to the current knowledge on systemically administered antimicrobials in periodontal treatment. Periodontitis is the most frequent chronic noncommunicable human disease. It is caused by dysbiotic bacterial biofilms and is commonly treated with subgingival instrumentation.
David Herrera, Arie Jan van Winkelhoff, Paula Matesanz, Katalina Lauwens, Wim Teughels   +4 more
wiley   +1 more source

Characteristics of male and female injecting drug users of the AjUDE-Brasil II Project

Cadernos de Saúde Pública
The object of this study is to compare female and male injection drug users (IDUs) in terms of sociodemographic profile and aspects of their initiation to the use of injection drugs.
Ana Maria de Oliveira Cintra, Waleska Teixeira Caiaffa, Sueli Aparecida Mingoti   +2 more
doaj  

SUBSTANCE ABUSE TREATMENT: WHAT DO WE KNOW? AN ECONOMIST’S PERSPECTIVE [PDF]

The substance abuse treatment literature has basically dealt with four important questions: 1) Is treatment effective? 2) Are all programs equally effective? 3) why do programs differ in their effectiveness?
Matilde P. Machado
core  

Competencies for Canada’s substance abuse workforce. [PDF]

, 2010
This report forms a supportive resource that identifies the technical and behavioural competencies required to perform effectively in the substance abuse field (from health promotion, support and outreach, counselling, withdrawal management, and ...

core  

Substance abuse and rehabilitation: responding to the global burden of diseases attributable to substance abuse

, 2010
Li-Tzy Wu*Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Duke University Medical Center, Durham, NC, USA *Li-Tzy Wu is the Editor-in-Chief of Substance Abuse and RehabilitationAbstract: Alcohol, tobacco, and illegal
Li-Tzy Wu, Wu, Li-Tzy
core   +1 more source

Patients With Atypical Symptoms of Depression Respond Better to Lithium Augmentation Than Patients Without Atypical Symptoms

Acta Psychiatrica Scandinavica, EarlyView.
ABSTRACT Introduction Understanding the differences in treatment response between subtypes of major depressive disorder (MDD) may help to prevent lengthy trial‐and‐error processes by identifying effective treatment options. The aim of the study was to investigate the impact of atypical features of MDD (MDD‐A) on the response to lithium augmentation (LA)
Hannah Buchbauer, Mazda Adli, Peter Schlattmann, Maximilian Berger, Tom Bschor, Thomas Stamm, Joachim Behr, Roland Ricken, Pichit Buspavanich   +8 more
wiley   +1 more source

Intravenous tapentadol abuse in treatment-seeking youngrural adults: a case series

Indian Journal of Mental Health and Neurosciences
Background: Tapentadol is a centrally acting opioid analgesic with m-opioid receptor agonism and norepinephrine reuptake inhibition. Although approved for the management of moderate to severe pain, emerging reports suggest increasing misuse of ...
Rajalakshmi Arunachalam, JaiKumar Velayutham, Rathika Pichaachari   +2 more
doaj   +1 more source

Psychedelic‐assisted treatment for substance use disorder: A narrative systematic review

Addiction, EarlyView.
Abstract Background and aims This is the first systematic review of the extant literature on all major psychedelic‐assisted treatment for alcohol use disorder (AUD), tobacco use disorder (TUD) and other substance use disorders (SUD). We aimed to summarise the evidence for efficacy of psychedelic‐assisted treatment for AUD, TUD, and SUD; to evaluate its
Theodore Piper, Francesca Small, Sam Brown, Michael Kelleher, Luke Mitcheson, James Rucker, Allan H. Young, John Marsden   +7 more
wiley   +1 more source