Results 51 to 60 of about 248,430 (244)

Intelligent Micro/Nanorobots for Targeted Interventional Therapy: From Bench to Clinic

Advanced Robotics Research, EarlyView.
Zirui Zhang et al. reviewed the application and challenges of mobile nanomachines in interventional therapy. By converting exogenous energy, including chemical, magnetic, optical, and ultrasonic sources, into mechanical forces, micro/nanorobots (MNRs) enable precise actuation at unprecedented scales. Evolving far beyond traditional drug delivery, these
Zirui Zhang, Yu Dong, Yongsheng Du, Rui Gao, Lin Zhang, Fei Tong   +5 more
wiley   +1 more source

Thrombolysis is associated with consistent functional improvement across baseline stroke severity: a comparison of outcomes in patients from the Virtual International Stroke Trials Archive (VISTA) [PDF]

, 2010
<p><b>Background and Purpose:</b> Baseline stroke severity predicts outcomes among thrombolysed patients. The baseline National Institutes of Health Stroke Scale (NIHSS) thresholds are sometimes used to select patients for thrombolysis,
Lees, K.R., Mishra, N.K., Nishant K. Mishra, Kennedy R. Lees, Grotta, J.C., Lyden, P., Patrick Lyden, James C. Grotta   +7 more
core   +1 more source

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

Advanced Science, EarlyView.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen, Chengxiang Zhang, Junhui Wang, Xichong Zhong, Shihao Chen, Xue Wang, Xiaokun Li, Li Lin   +7 more
wiley   +1 more source

Impact of obesity on stroke outcome after intravenous thrombolysis [PDF]

, 2011
BACKGROUND AND PURPOSE: Obesity is an established risk factor for stroke and has reached epidemic proportions. However, its impact on intravenous thrombolysis applied for acute ischemic stroke is not well known.
Sarikaya, Hakan, Arnold, Marcel, Georgiadis, Dimitrios, Dimitrios Georgiadis, Elmas, F, Elmas, Firat, Georgiadis, D, Hakan Sarikaya, Arnold, M, Ralf W. Baumgartner, Sarikaya, H, Baumgartner, R W, Baumgartner, Ralf W, Firat Elmas, Marcel Arnold   +14 more
core   +1 more source

Early outcomes of thrombolysis for acute ischaemic stroke in a South African tertiary care centre [PDF]

, 2012
Includes abstract.Includes bibliographical references.Stroke is an important cause of death and disability in sub-Saharan Africa. Recombinant tissue plasminogen activator (tPA) thrombolysis is effective in treating acute ischaemic stroke, but may not be ...
Wasserman, Sean
core   +1 more source

SR‐A3 Promotes USP18‐Mediated deISGylation of STING to Protect Against Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
MI/RI is a major clinical challenge with high morbidity and mortality. This study demonstrates that SR‐A3 expression is downregulated in MI/RI, and its deletion exacerbates damage via the USP18/ISG15/STING axis, revealing SR‐A3 as a potential therapeutic target.
Yufei Han, Guolin Miao, Yinqi Zhao, Zhiyong Du, Kaikai Lu, Changqi Xiao, Aiden Xian, Jiaxin Duanmu, Zihao Zhou, Jinxuan Chen, Lianxin Zhang, Chao Zhai, Yitong Xu, Zhaoling Li, Xianqin Shen, Sijing Shi, Jingxuan Chen, Si Mei, Yuan Fang, Liwen Zheng, Ling Zhang, Yuhui Wang, Wei Huang, Erdan Dong, Xunde Xian   +24 more
wiley   +1 more source

Factors associated with intracerebral hemorrhage after thrombolytic therapy for ischemic stroke pooled analysis of placebo data from the Stroke-Acute Ischemic NXY Treatment (SAINT) I and SAINT II trials [PDF]

, 2009
<p><b>Background and Purpose:</b> A number of factors have been associated with postthrombolysis intracerebral hemorrhage, but these have varied across studies.</p> <p><b>Methods:</b> We examined patients with
Demchuk, A., Lees, K.R., Kasner, S.E., Messe, S.R., Cucchiara, B., Levine, S.R., Lyden, P., Sansing, L., Tanne, D.   +8 more
core   +1 more source

N-Terminal Pro-brain Natriuretic Peptide Is Associated With Hemorrhagic Transformation and Poor Outcomes in Patients With Stroke Treated With Intravenous Thrombolysis

Frontiers in Molecular Neuroscience, 2021
Background: N-terminal pro-brain natriuretic peptide (NT-proBNP) levels are a promising biomarker for predicting stroke outcomes; however, their prognostic validity is not well-understood in patients who have undergone intravenous thrombolysis.
Ke-Jia Zhang, Ke-Jia Zhang, Hang Jin, Hang Jin, Rui Xu, Rui Xu, Peng Zhang, Peng Zhang, Zhen-Ni Guo, Zhen-Ni Guo, Yi Yang, Yi Yang   +11 more
doaj   +1 more source

Nano Proton Scavengers Modulate Endosomal pH to Inhibit Microglial Activation and Enhance Stroke Recovery

Advanced Science, EarlyView.
Amphiphilic sulfonated chitosan nanoparticles buffer endo/lysosomal acidity in microglia by limiting V‐ATPase membrane recruitment and restoring endosomal homeostasis. Following systemic administration, they accumulate in the ischemic hemisphere partly through association with infiltrating immune cells, suppress TLR3/IRF3 and TLR4/NF‐κB signaling ...
Xuanlin Wang, Yujing Shi, Zehua Gao, Jing Wang, Changsheng Liu   +4 more
wiley   +1 more source

Outcomes of intravenous thrombolysis in posterior versus anterior circulation stroke [PDF]

, 2011
BACKGROUND AND PURPOSE: Intravenous thrombolysis is an approved treatment for anterior (ACS) and posterior (PCS) circulation stroke. However, no randomized controlled trial has investigated safety and efficacy of intravenous thrombolysis according to ...
Sarikaya, Hakan, Arnold, Marcel, Georgiadis, Dimitrios, Baumgartner, Ralf W., Engelter, Stefan T, Bonati, L H, Mattle, Heinrich P., Fluri, Felix, Fischer, Urs, Georgiadis, D, Fischer, U, Lyrer, Philippe A., Arnold, M, Felix Fluri, Engelter, S T, Urs Fischer, Sarikaya, H, Bonati, Leo H., Baumgartner, Ralf W, Ballinari, P, Fluri, F, Dimitrios Georgiadis, Ballinari, Pietro, Bonati, Leo H, Leo H. Bonati, Stefan T. Engelter, Philippe A. Lyrer, Heinrich P. Mattle, Mattle, H P, Lyrer, Philippe A, Lyrer, P A, Hakan Sarikaya, Ralf W. Baumgartner, Baumgartner, R W, Oliver Findling, Findling, Oliver, Engelter, Stefan T., Findling, O, Mattle, Heinrich P, Marcel Arnold, Pietro Ballinari   +40 more
core   +1 more source