Results 61 to 70 of about 248,430 (244)

Safety of thrombolysis in acute ischemic stroke patients with previous aortic abdominal aneurysm repair

Journal of Stroke and Cerebrovascular Diseases
Objective: Intravenous thrombolysis is the standard treatment for acute ischemic stroke (AIS), but its safety in patients with a history of abdominal aortic aneurysm (AAA) repair remains unclear.
Walter Duarte-Celada, MD, Katherine Rivas, MD, Pichatorn Suppakitjanusant, MD, Pamela Davila-Siliezar, MD, Myriam Vijil, MD, Ximena Gamboa, MD, Chanaka N. Kahathuduwa, MD, PhD, Riichi Ota, MD, Ross Raedeke, Darko Quispe-Orozco, MD   +9 more
doaj   +1 more source

β‐Adducin Restrains PLA2G4A‐Dependent Lysosomal Membrane Permeabilization and Neuronal Death in Ischemic Stroke

Advanced Science, EarlyView.
This study identifies β‐adducin as a regulator of lysosomal integrity in ischemic neurons. Ischemia‐associated FTO loss increases m6A modification and destabilizes Add2 mRNA, reducing β‐adducin expression and promoting PLA2G4A accumulation at lysosomes.
Hui‐qin Li, Pin‐yi Liu, Dan Wu, Fei‐yu Ma, Yi Bai, Sheng‐nan Xia, Hai‐yan Yang, Xin‐yu Bao, Yun Xu, Xiang Cao   +9 more
wiley   +1 more source

Intravenous tPA therapy does not worsen acute intracerebral hemorrhage in mice [PDF]

, 2013
Tissue plasminogen activator (tPA) is the only FDA-approved treatment for reperfusing ischemic strokes. But widespread use of tPA is still limited by fears of inadvertently administering tPA in patients with intracerebral hemorrhage (ICH).
Emiri Mandeville, Cianchetti, Flor A., Ken Arai, van Leyen, Klaus, Frieder Schlunk (280822), Eng H. Lo (112154), Kazim Yigitkanli, Chris B Schaffer, Mandeville, Emiri, Yigitkanli, Kazim, Xiaoying Wang, Nathanael L Rosidi, Chris B. Schaffer (155846), Arne Lauer (280824), Fan, Xiang, Eng H Lo, Helmuth Steinmetz (149409), Rosidi, Nathanael L., Xiang Fan (280830), Schlunk, Frieder, Frieder Schlunk, Flor A. Cianchetti (280825), Wang, Xiaoying, Christian Foerch (149410), Flor A Cianchetti, Kazim Yigitkanli (280829), Arai, Ken, Förch, Christian, Leyen, Klaus van, Lo, Eng H., Foerch, Christian, Xiang Fan, Schaffer, Chris B., Ken Arai (280828), Klaus van Leyen, Helmuth Steinmetz, Emiri Mandeville (280827), Steinmetz, Helmuth, Christian Foerch, Lo, Eng, Arne Lauer, Nathanael L. Rosidi (280821), Xiaoying Wang (30853), Klaus van Leyen (280831), Lauer, Arne   +44 more
core   +2 more sources

Clinical worsening despite intravenous thrombolysis in acute ischemic stroke secondary to carotid plaque rupture [PDF]

, 2020
First-line therapy of acute ischemic stroke is intravenous thrombolysis (IVT) irrespective of etiology. We report on a patient with acute ischemic stroke secondary to carotid plaque rupture who experienced plaque thrombosis and marked clinical worsening ...
Mascolo A. P., Diomedi M., Marrama F., Sallustio F., Fresilli M., Sama D.   +5 more
core   +1 more source

Intravenous Thrombolysis in Patients on Direct Oral Anticoagulants: Analysis of the Get With The Guidelines Stroke Registry

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Intravenous thrombolysis for acute ischemic stroke (AIS) is a proven effective treatment. Whether thrombolysis in patients with AIS with recent direct oral anticoagulant (DOAC) use is safe and efficacious is not well established.
Shadi Yaghi, Liqi Shu, Eva A. Mistry, Opeolu Adeoye, Lee Schwamm, Steven Messe, Mitchell S. V. Elkind, Malik Ghannam, Adam de Havenon, Karen Furie, Ying Xian, Christopher Streib, Runqi Wangqin, Nils Henninger, Jeffrey L. Saver, Eric E. Smith   +15 more
doaj   +1 more source

Risk factors are different for deep and lobar remote hemorrhages after intravenous thrombolysis.

PLoS ONE, 2017
Background and purposeRemote parenchymal haemorrhage (rPH) after intravenous thrombolysis is defined as hemorrhages that appear in brain regions without visible ischemic damage, remote from the area of ischemia causing the initial stroke symptom.
Luis Prats-Sanchez, Alejandro Martínez-Domeño, Pol Camps-Renom, Raquel Delgado-Mederos, Daniel Guisado-Alonso, Rebeca Marín, Laura Dorado, Salvatore Rudilosso, Alejandra Gómez-González, Francisco Purroy, Manuel Gómez-Choco, David Cánovas, Dolores Cocho, Moises Garces, Sonia Abilleira, Joan Martí-Fàbregas   +15 more
doaj   +1 more source

Determinants of 1-Year Unfavorable Outcomes of Intravenous Alteplase Thrombolysis for Acute Ischemic Stroke

Clinical and Applied Thrombosis/Hemostasis, 2023
Objective Intravenous thrombolytic therapy has become the standard of treatment for eligible patients with ischemic stroke. However, outcomes after receiving intravenous thrombolytic therapy vary widely.
Mingfeng Zhai MD, Jinwei Yang MD, Xiaoyan Cao MD, Yingying Li MD, Hui Xu MD, Yu Wang MD   +5 more
doaj   +1 more source

Neutrophil Extracellular Traps Block Fibrinolysis in Ischemic Stroke

Annals of Neurology, EarlyView.
Objectives Intravenous thrombolysis (IVT) failure in acute ischemic stroke (AIS) is frequent, but its causes remain elusive. We investigated whether biologically relevant intrathrombus concentrations of tissue plasminogen activator (tPA) were achieved in failed IVT and whether neutrophil extracellular traps (NETs) contributed to this therapeutic ...
Mialitiana Solo Nomenjanahary, Jean‐Philippe Desilles, Fatima Zemali, Astride Perrot, Lucas Di Meglio, Sara Zalghout, Jéromine Fasille, Jérémy Neel, Stéphane Loyau, Julien Labreuche, Marie‐Charlotte Bourrienne, Dorothée Faille, François Delvoye, Véronique Ollivier, Sébastien Dupont, Jasmina Rogozarski, Nahida Brikci‐Nigassa, Robert L. Medcalf, Nadine Ajzenberg, Mikael Mazighi, Benoît Ho‐Tin‐Noé, the compoCLOT Study Group   +21 more
wiley   +1 more source

Endovascular therapy versus intravenous thrombolysis in cervical artery dissection ischemic stroke – Results from the SWISS registry [PDF]

, 2018
Introduction In patients with stroke attributable to cervical artery dissection, we compared endovascular therapy to intravenous thrombolysis regarding three-month outcome, recanalisation and complications.
Simonetti, Barbara Goeggel, Gralla, J., Henrik Gensicke, Steiner, L., Engelter, Stefan T, Philippe A Lyrer, Mueller, H., Susanne Wegener, Weber, J., Kaegi, Georg, Fischer, U., Levke Steiner, Mueller, Hubertus, Muller, Hubertus, Ashraf Eskandari, Nils Peters, Francesco Puccinelli, Sztajzel, R., Kägi, Georg, Lövblad, Karl-Olof, Eskandari, Ashraf, Arnold, M., Luft, A., Stippich, Christoph, Rebekka Kurmann, Kurmann, Rebekka, Bonati, L.H., Simonetti, B.G., Eskandari, A., Andreas Luft, Marcel Arnold, Stippich, C., Patrik Michel, Barbara Goeggel Simonetti, Johannes Weber, Traenka, Christopher, Arnold, Marcel, Christoph Stippich, Engelter, S.T., Steiner, Levke, Sztajzel, Roman, Gralla, Jan, Fischer, Urs, Wegener, S., Lyrer, Philippe A., Puccinelli, F., Urs Fischer, Lovblad, Karl, Jochen Vehoff, Jung, S., Luft, Andreas, Vehoff, J., Bonati, Leo H., Goeggel Simonetti, Barbara, Peters, N., Michel, Patrik, Simon Jung, Lyrer, P.A., Jung, Simon, Weber, Johannes, Bonati, Leo H, Vehoff, Jochen, Gensicke, Henrik, Georg Kägi, Peters, Nils, Lyrer, Philippe A, Karl Lovblad, Stefan T Engelter, Lovblad, K., Christopher Traenka, Traenka, C., Kurmann, R., Kägi, G., Roman Sztajzel, Jan Gralla, Hubertus Mueller, Gensicke, H., Puccinelli, Francesco, Wegener, Susanne, Leo H Bonati, Michel, P.   +80 more
core   +1 more source

Spinal subdural hematoma as a complication of tenecteplase treatment for acute ischemic stroke: A case report

Heliyon
Intravenous thrombolysis is an effective treatment for acute ischemic stroke. The ESO recommends that tenecteplase be used for thrombolytic therapy in stroke within 4.5h of onset.
Sisi Zhao, Lingtao Tang, Yanpeng Lu, Yingyi Li   +3 more
doaj   +1 more source