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Mechanical Thrombectomy Versus Medical Management for Large Ischemic Core Stroke Identified before Inter‐Hospital Transfer: A Post Hoc Analysis of the LASTE Trial
Annals of Neurology, EarlyView.Objective
This study assessed the efficacy of thrombectomy in acute ischemic stroke because of large‐vessel occlusion (AIS‐LVO) initially admitted to primary stroke centers (PSC) and subsequently transferred to a comprehensive stroke center (CSC), with a large ischemic core identified before transfer.Pierre Seners, Adrien ter Schiphorst, Julien Labreuche, Bertrand Lapergue, Hilde Henon, Nasreddine Nouri, Benjamin Gory, Sébastien Richard, Jean‐François Albucher, Christophe Cognard, Liesjet E.H. van Dokkum, David S. Liebeskind, Tudor G. Jovin, Vincent Costalat, Caroline Arquizan, for the LASTE investigators, Caroline Arquizan, Vincent Costalat, Xavier Ayrignac, Mahmoud Charif, Lucas Corti, Cyril Dargazanli, Imad Derraz, Nicolas Gaillard, Grégory Gascou, Pierre‐Henri Lefevre, Anaïs Lippi, Isabelle Mourand, Pauline Prin, Perrine Schmitt, Florian Savenier, Adrien Ter Schiphorst, Igor Sibon, Gaultier Marnat, Pierre Briau, Florent Gariel, Jean‐Sébastien Liegey, Malgorzata Milnerowicz, Jean Papaxanthos, Lisa Papillon, Sophie Godard, Anne Pasco‐Papon, Alice Corfu, Jean‐Baptiste Girot, Vincent L'Allinec, Alderic Lecluse, Matthias Lamy, Stéphane Velasco, Nadeem Beydoun, Samy Boucebci, Victor Dumas, Cédric Fauche, Jean‐Philippe Neau, Paola Palazzo, Nicolas Raynaud, Emmanuel Houdart, Mikael Mazighi, Agnès Aghetti, Anna Dimitrovic, Alexis Guedon, Peggy Reiner, Olivier Naggara, Guillaume Turc, Wagih Benhassen, Basile Kerleroux, Christine Rodriguez Regent, Frédéric Clarencon, Sonia Alamowitch, Julien Allard, Flore Baronnet, Sophie Crozier, Stephen Delorme, Sandrine Deltour, Gaspard Gerschenfeld, Anne leger, Kevin Premat, Charlotte Rosso, Yves Samson, Eimad Shotar, Laurent Spelle, Christian Denier, Jildaaz Caroff, Vanessa Chalumeau, Olivier Chassin, Sophie Gallas, Léon Ikka, Nicolas Legris, Mariana Sarov Riviere, Laura Venditti, Benjamin Gory, Sébastien Richard, René Anxionnat, Mathieu Bonnerot, Liang Liao, Nolwenn Riou‐Comte, Romain Bourcier, Benoît Guillon, Pierre‐Louis Alexandre, Benjamin Daumas‐Duport, Hubert Desal, Lili Detraz, Cécile Preterre, Valérie Wolff, Raoul Pop, Yannick Bejot, Frédéric Ricolfi, Laura Baptiste, Pierre‐Olivier Comby, Brivael Lemogne, Pierre Thouant, Jean‐Christophe Gentric, Serge Timsit, François‐Mathias Merrien, Lorena Nico, Julien Ognard, Laurina Simoni, Chrysanthi Papagiannaki, Ozlem Ozkul, Aude Triquenot Bagan, Michel Piotin, Michael Obadia, Pierre Seners, Nasreddine Nouri, Hilde Henon, Marie Bodenant, Nicolas Bricout, Barbara Casolla, Nelly Dequatre, Lucie Della Shiava, Maco Pasi, François Caparros, Laurent Puy, Arnaud Karam, Olfa Kaaouana, Kaelig Watel, Giuseppe Scopelliti, Mariam Annan, Grégoire Boulouis, Richard Bibi, Arnaud Bretonniere, Marie Gaudron, Denis Herbreteau, Héloise Ifergan, Kevin Jannot, Elisabeth Molinier, Maco Pasi, Cyril Chivot, Chantal Lamy, Emmanuel Wiener, Audrey Arnoux Courselle, Sandrine Canaple, Elisa Ouin, Charbel Mounayer, Francisco Macian Montoro, Suzana Saleme, Omer Eker, Tae‐Hee Cho, Morgane Laubacher, Roberto Riva, Christophe Cognard, Jean‐François Albucher, Lionel Calviere, Louis Fontaine, Jean‐Marc Olivot, Nicolas Raposo, Alain Viguier, Laurent Suissa, Hervé Brunel, Emilie Doche, Nadia Laksiri, Stephanie Machado, Ophelie Osman, Roxane Peres, Emanuelle Robinet, Caroline Rey, Federico Di Maria, Bertrand Lapergue, Emmanuel Chabert, Anna Ferrier, Elie Lteif, Pere Cardona, Lara Blanca, Helena Quesada, Ana Núñez, Andrés Paipa, Mònica Millán, Alejandro Bustamante, Laura Dorado Bouix, Christopher Calib, Jaime Carbonell, Gema Eugenia García Amor, Garbiñe Ezcurra, Belén Flores, Manuel Gómez Choco, Meritxell Gomis Cortina, María Hernández Pérez, Marina Hernández, Clara Larrañaga, Manuel Domínguez Lizarbe, Marina Martínez, Alex Menéndez Albarracín, Natalia Pérez de la Ossa, Neus Rabaneda, Anna Ramos Pachón, Luis Alejandro Rodríguez, Sara Rubio, Isabel Puig, Daniel Santana l, Adrian Valls, Barbara Yugueros, Denisse Wenger, Arturo Renú, Sergio Amaro, Mircea Balasa, Jose Maria Cabrera, Ángel Chamorro, Estefania Conde, Jose Miguel Contador, Antonio Doncel‐Mariano, Mar Guasp, Laura Llansó, Laura Llull, Gerard Mayà Casalprim, Carmen Montejo, Alejandro Rodríguez, Salvatore Rudilosso, Almudena Sánchez, Daniel Santana, Xabier Urra Nuin, Víctor Augusto Vera Monge, Juan F. Arenillas, Mercedes De Lera, María Esther Ramos, María del Mar Freijo, Garazi Aguirre, Laura Cabral, Irene Díaz, Alejandro Durán Lozano, Alain Luna, Jon Martín, Ana Moreno Estébanez, Walter Sifontes, Iratxe Ugarriza, Elena López‐Cancio, Pedro Vega, Lorena Benavente, Sergio Calleja Puerta, María Castañón Apilánez, Álvaro Criado, David Fuentes, Carmen García‐Cabo, Montserrat González Delgado, Gemma María González, Javier Molina Gil, Davinia Larrosa Campo, Begoña López López, Antía Reguera Acuña, María Rico Santos, Patricia Zunzunegui +258 morewiley +1 more sourceWarfarin anticoagulation exacerbates the risk of hemorrhagic transformation after rt-PA treatment in experimental stroke: therapeutic potential of PCC [PDF]
, 2011 Background: Oral anticoagulant therapy (OAT) with warfarin is the standard of stroke prevention in patients with atrial fibrillation. Approximately 30% of patients with cardioembolic strokes are on OAT at the time of symptom onset.Förch, Christian, Waltraud Pfeilschifter, Daniel Spitzer, Pfeilschifter, Josef (Prof. Dr.), Helmuth Steinmetz, Spitzer, Daniel, Steinmetz, Helmuth, Steinmetz Helmuth, Christian Foerch, Pfeilschifter, Waltraud, Josef Pfeilschifter, Pfeilschifter Waltraud, Spitzer Daniel, Foerch Christian, Pfeilschifter Josef +14 morecore +2 more sourcesCerebral No‐Reflow after Thrombectomy: International Delphi Consensus on Definition and Imaging Assessment
Annals of Neurology, EarlyView.Background
The operational definition and imaging assessment of the no‐reflow phenomenon, a potential contributor to poor clinical outcome despite successful thrombectomy, remains debated. We aimed to develop expert‐based international consensus on the definition, assessment, and reporting standard of cerebral no‐reflow post‐thrombectomy. Methods
Three‐Adnan Mujanovic, Samantha Rivet, Adrien ter Schiphorst, Jean‐Claude Baron, Johannes Kaesmacher, Felix Ng, Cerebral No‐Reflow Delphi‐Consensus Group, Pooja Khatri, Xin Cheng, Andrea Zini, Maria Hernandez Perez, Ettore Nicolini, Marta Rubiera, Charlotte Rosso, Marie Luby, Victor Del Brutto, Christopher Favilla, Angel Chamorro, Angelika Hoffman, David Liebeskind, Sven P. R. Luijten, Moritz Hernandez Petzsche +21 morewiley +1 more sourceIntravenous thrombolysis for acute ischemic stroke
Diagnostic and Interventional Imaging, 2014 Intravenous thrombolysis (IVT) with alteplase remains the standard treatment for acute ischemic stroke. Although IVT can be started up to 4.5 hours after symptoms' onset, it is all the more effective and safe when started early. It allows a 10% absolute reduction in the risk of handicap or death at 3 months, despite a 2-7% risk of symptomatic ...Turc, G., Isabel, C., Calvet, D.openaire +2 more sourcesThe mechanisms of reperfusion during in stroke patients treated with intravenous thrombolysis
Неврология, нейропсихиатрия, психосоматика, 2012 Systemic (intravenous) thrombolysis with recombinant tissue plasminogen activator (rt-PA) is a proved effective treatment modality in a certain group of patients with ischemic stroke (IS) in the first 4.5 hours after the onset of neurological symptoms ...Maksim Alekseyevich Domashenko, M Yu Maksimova, M A Loskutnikov, A A Nikonov, V V Bryukhov, A S Suslin, M V Dreval, R N Konovalov +7 moredoaj +1 more source