Results 141 to 150 of about 132,395 (346)

Optimizing Measurement of Vascular Endothelial Growth Factor in Small Blood Samples of Premature Infants [PDF]

, 2019
To establish a method that allows for the reliable assessment of vascular endothelial growth factor (VEGF-A) concentrations in very small blood samples of preterm infants. Systemic VEGF measurements are important in view of the most appropriate Anti-VEGF
Lopez Yomayuza, Claudia C., Lorenz, Birgit, Preissner, Klaus T., Stieger, Knut   +3 more
core   +1 more source

Superior Retinal Gene Transfer and Biodistribution Profile of Subretinal Versus Intravitreal Delivery of AAV8 in Nonhuman Primates.

Investigative Ophthalmology and Visual Science, 2017
Purpose To investigate shedding and biodistribution characteristics of recombinant adeno-associated virus serotype 8 (rAAV8) after single-dose subretinal or intravitreal injection in nonhuman primates (NHP, Macaca fascicularis) as a surrogate for ...
I. Seitz, S. Michalakis, B. Wilhelm, F. Reichel, G. A. Ochakovski, E. Zrenner, M. Ueffing, M. Biel, B. Wissinger, K. Bartz-Schmidt, T. Peters, M. D. Fischer   +11 more
semanticscholar   +1 more source

Internal closure of a posterior perforation using amniotic membrane: A novel surgical technique

Acta Ophthalmologica, EarlyView.
J. S. Suwandi, B. A. van der Wel, E. H. C. van Dijk, S. S. Manning, M. Manzulli, P. Geeraert, S. van Romunde, K. Faridpooya   +7 more
wiley   +1 more source

Characterizing and assessing vision‐related quality of life among patients discontinued treatment for neovascular age‐related macular degeneration

Acta Ophthalmologica, EarlyView.
Abstract Purpose This study characterized and assessed vision‐related quality of life (VRQoL) in patients with neovascular age‐related macular degeneration (nAMD) who discontinued treatment with intravitreal anti‐vascular endothelial growth factor (anti‐VEGF), comparing them to those undergoing treatment.
Noreddin Shekho, Anna Stage Vergmann, Frederik Nørregaard Pedersen, Lonny Stokholm, Benjamin Sommer Thinggaard   +4 more
wiley   +1 more source

Intravitreal Injection of Bone Marrow Mesenchymal Stem Cells in Patients with Advanced Retinitis Pigmentosa; a Safety Study

Journal of Ophthalmic & Vision Research, 2017
Purpose: To examine the safety of a single intravitreal injection of autologous bone Marrow Mesenchymal stem cells (MSCs) in patients with advanced retinitis pigmentosa (RP).
L. Satarian, R. Nourinia, S. Safi, M. Kanavi, Neda Jarughi, N. Daftarian, L. Arab, N. Aghdami, H. Ahmadieh, H. Baharvand   +9 more
semanticscholar   +1 more source

Randomized, single‐centre, double‐blinded repeated dose investigation of safety and tolerability of ocular administrations of a novel silica eye drop product in healthy volunteers

Acta Ophthalmologica, EarlyView.
Abstract Purpose Managing ocular diseases often requires frequent eye drop administration, which can challenge patient compliance. A long‐acting eye drop technology using an amorphous synthetic silica composite was developed to address this. Our study aimed to assess the safety and tolerability of the Silica Eye Drop platform in healthy volunteers over
Aleksandra Poluianova, Marceline N. Akieh‐Pirkanniemi, Arto Hartikainen, Hanna Arstila, Kai Kaarniranta, Lasse Leino   +5 more
wiley   +1 more source

Bioactive Glial-Derived Neurotrophic Factor from a Safe Injectable Collagen–Alginate Composite Gel Rescues Retinal Photoreceptors from Retinal Degeneration in Rabbits

Marine Drugs
The management of vision-threatening retinal diseases remains challenging due to the lack of an effective drug delivery system. Encapsulated cell therapy (ECT) offers a promising approach for the continuous delivery of therapeutic agents without the need
Tingyu Hu, Ting Zhou, Rajesh Kumar Goit, Ka Cheung Tam, Yau Kei Chan, Wai-Ching Lam, Amy Cheuk Yin Lo   +6 more
doaj   +1 more source

Viral Vector-based Improvement of Optic Nerve Regeneration: Characterization of Individual Axons\u27 Growth Patterns and Synaptogenesis in a Visual Target [PDF]

, 2015
Lack of axon growth ability in the central nervous system poses a major barrier to achieving functional connectivity after injury. Thus, a non-transgenic regenerative approach to reinnervating targets has important implications in clinical and research ...
Blackmore, Murray G., Luo, Xueting, Salgueiro, Yadira, Yungher, Benjamin J.   +3 more
core   +1 more source

Real-World Effectiveness and Real-World Cost-Effectiveness of Intravitreal Aflibercept and Intravitreal Ranibizumab in Neovascular Age-Related Macular Degeneration: Systematic Review and Meta-Analysis of Real-World Studies

Advances in Therapy, 2019
Introduction Treatment of neovascular age-related macular degeneration (nAMD) has evolved with the advent of anti-vascular endothelial growth factor agents such that intravitreally administered aflibercept and ranibizumab (RBZ) have become the standard ...
J. Carrasco, G. Pietsch, Marie-Pierre Nicolas, C. Koerber, C. Bennison, Jisu Yoon   +5 more
semanticscholar   +1 more source

Outcomes and complications of sponges versus tires for scleral buckling in primary rhegmatogenous retinal detachment: The Manchester Buckle Study

Acta Ophthalmologica, EarlyView.
Abstract Purpose To compare preoperative characteristics and postoperative anatomical and functional outcomes of scleral buckle surgery using sponges versus tires, as well as explant‐related complications and the frequency of explant removal. Methods This retrospective study included patients with primary rhegmatogenous retinal detachment (RRD) who ...
Peter Kiraly, Myrta Lippera, Naseer Ally, Ritu Agarwal, George Moussa, Tsveta Ivanova, Felipe Dhawahir‐Scala, Niall Patton, George Turner, Stephen Charles, Assad Jalil, Kirti M. Jasani   +11 more
wiley   +1 more source