Results 141 to 150 of about 1,515,099 (315)

2018 Update on Intravitreal Injections: Euretina Expert Consensus Recommendations

open access: yesOphthalmologica, 2018
A. Grzybowski   +6 more
semanticscholar   +1 more source

Microglial Deletion of Hrh4 Alleviates Alzheimer's Disease Pathologies by Enhancing Microglial Phagocytosis of Amyloid‐β and Tau

open access: yesAdvanced Science, Volume 13, Issue 2, 9 January 2026.
Histamine H4 receptor (H4R) antagonist VUF6002 mimics low‐dose X‐ray irradiation in aged Alzheimer's disease (AD) mice, enhancing microglial clearance of amyloid‐beta/hyperphosphorylated tau aggregates and restoring cognition. Microglial H4R deletion activates cAMP/TGF‐β1/Smad3 pathway, enhancing phagocytosis, while TGF‐β receptor 1 deletion abolishes ...
Yi‐Jun Xu   +5 more
wiley   +1 more source

TSHR‐Targeting Nucleic Acid Aptamer Treats Graves' Ophthalmopathy via Novel Allosteric Inhibition

open access: yesAdvanced Science, Volume 13, Issue 4, 19 January 2026.
This study presents YC3, a novel inhibitory TSHR‐targeting aptamer, as a promising therapeutic for Graves' ophthalmopathy (GO). YC3 suppresses pathological phenotypes in human orbital fibroblasts and improves outcomes in GO mice by binding to a previously unidentified allosteric site on TSHR, demonstrating the potential of aptamers in advancing ...
Yanchen Zhang   +16 more
wiley   +1 more source

Vancomycin‐Functionalized Nanodelivery Systems for Antibacterial Tissue Engineering Scaffolds

open access: yesAdvanced NanoBiomed Research, Volume 6, Issue 1, January 2026.
This review consolidates recent advancements in VAN nanoformulations, critically evaluating their design principles, release mechanisms, and efficacy profiles against resistant Gram‐positive pathogens. While promising in vitro and in vivo results have been demonstrated, the clinicaltranslation of these technologies necessitates further rigorous ...
Nima Beheshtizadeh   +5 more
wiley   +1 more source

Development and Characterization of a Noncovalent Stimulator of Interferon Genes Proteolysis‐Targeting Chimeras

open access: yesChemMedChem, Volume 21, Issue 1, January 2026.
The design, synthesis, and initial biological evaluation of noncovalent stimulator of interferon genes degraders are presented. The lead from this series, BH690L, exhibits an effective concentration for half‐maximal degradation (DC50) of 11.3 nM and a maximum level of degradation (Dmax) of 0.67.
Bo Hu, Adam S. Duerfeldt
wiley   +1 more source

Factors associated with pain during intravitreal injection of anti-vascular endothelial growth factor [PDF]

open access: bronze, 2018
Ngoc Chau Isabelle Nguyen   +6 more
openalex   +1 more source

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