Results 51 to 60 of about 31,184 (259)

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Intravitreal silicone oil droplet after intravitreal injection

Journal of Retina-Vitreous, 2022
Currently, anti-vascular endothelial growth factor agents (anti-VEGF) are frequently used in the treatment of diseases such as age-related macular degeneration and diabetic macular edema. In our study, we discussed three cases in which intravitreal silicone oil droplets were detected during the follow-up after intravitreal anti-VEGF agent ...
Çetin, Ebru Nevin, Pekel, Gökhan, Akbulut, Selen   +2 more
openaire   +2 more sources

Comparison of Intravitreal Bevacizumab Upload Followed by a Dexamethasone Implant versus Dexamethasone Implant Monotherapy for Retinal Vein Occlusion with Macular Edema [PDF]

, 2012
Purpose: To compare the efficacy and safety of three intravitreal bevacizumab upload injections followed by a dexamethasone implant versus dexamethasone implant monotherapy in eyes with macular edema due to retinal vein occlusion.
Haritoglou, Christos, Mayer, Wolfgang J., Wolf, Armin, Kook, Daniel, Ulbig, Michael, Reznicek, Lukas, Remy, Matthias, Kampik, Anselm   +7 more
core   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Embryonic Intravitreous Injection in Mouse

BIO-PROTOCOL, 2018
Axons of retinal ganglion cells (RGCs) relay visual information from the retina to lateral geniculate nucleus (LGN) and superior colliculus (SC), which are two major image-forming visual nuclei. Wiring of these retinal projections completes before vision begins.
Liyuan Cui, Yupu Diao, Jiayi Zhang
openaire   +4 more sources

A Viscous DES‐AAV‐Foxo1 Delivery System With High Transfection Efficiency for the Treatment of Corneal Endothelial Dysfunction by Restoring Mitochondria‐ER Contacts

Advanced Science, EarlyView.
High glucose triggers corneal endothelial dysfunction by impairing FOXO1‐mediated ITPR1 transcription, leading to disrupted mitochondria‐associated membrane (MAM) integrity and defective ER‐to‐mitochondria Ca2+ transfer. This study develops an innovative viscous DES‐AAV‐Foxo1 delivery system with enhanced transfection efficiency. This non‐invasive gene
Hongran Zhao, Xiaoyu Li, Hongwei Wang, Zongyi Li, Qun Wang, Yangyang Zhang, Xu Jing, Xia Qi, Qingjun Zhou, Shengqian Dou, Lixin Xie   +10 more
wiley   +1 more source

Intravitreal injection: balancing the risks [PDF]

Eye, 2007
Intravitreal triamcinolone (iVTA) had gathered pace in the management of retinal diseases. By simply searching with the string ‘intravitreal triamcinolone’ in PubMed, it returns over 400 publications, with over 300 in the past 2 years. Despite the large number of publications, there are still very limited data on long-term efficacy (over 12 months ...
N V, Chong, T, Adewoyin
openaire   +2 more sources

Intravitreal injections during anticoagulant treatment

, 2008
Background: The number of intravitreal injections has increased steadily over the past few years. The aim of this prospective study was to evaluate the safety of intravitreal injections in patients under concurrent oral anticoagulation or antiplatelet ...
Horn, W. C., Hoerauf, Hans
core   +1 more source

Intravitreal Injections with Vascular Endothelial Growth Factor Inhibitors: A Practical Approach [PDF]

, 2020
Intravitreal injections with vascular endothelial growth factor inhibitors constitute the most prevalent ophthalmic procedure in developed countries.
Petri, Anne-Sofie, Mastropasqua, Rodolfo, Fuchs, Josefine, Cehofski L. J., Subhi Y., Subhi, Yousif, Mastropasqua, R., van Dijk E. H. C., Subhi, Yousif; id_orcid, Dysli, Chantal, Boysen, K., Subhi, Y., Petri A. -S., Mastropasqua R., Petri, Anne Sofie, Boysen K., van Dijk, Elon H. C., Fuchs J., Petri, A.S., van Dijk, Elon H.C., Dysli C., Cehofski, L.J., Dysli, C., Dijk, E.H.C. van, Fuchs, J., Boysen, Kirstine, Cehofski, Lasse J.   +26 more
core   +1 more source

Eye‐Brain Neuroimmune Axis Enables Long‐Term Survival in Glioblastoma by Modulating Brain Immune Surveillance and Neuronal Excitability

Advanced Science, EarlyView.
The eye–brain neuroimmune axis triggers immune activation and disrupts pathological neuronal connectivity to extend glioblastoma survival. ABSTRACT As an anatomical extension of the central nervous system (CNS), the eye harbors rich neural and immune interfaces with the brain. However, the integrated immunological and neurological nexus between the eye
Mingyue Cui, Lulu Qian, Binbin Chu, Xuan Qin, Menglin Wu, Minke Wu, Tongyu He, Baochuan Zhang, Bin Song, Yao He   +9 more
wiley   +1 more source