Results 61 to 70 of about 8,419,741 (275)

Brain mechanical property measurement using MRE with intrinsic activation [PDF]

Physics in Medicine and Biology, 2012
Many pathologies alter the mechanical properties of tissue. Magnetic resonance elastography (MRE) has been developed to noninvasively characterize these quantities in vivo. Typically, small vibrations are induced in the tissue of interest with an external mechanical actuator.
John B, Weaver, Adam J, Pattison, Matthew D, McGarry, Irina M, Perreard, Jessica G, Swienckowski, Clifford J, Eskey, S Scott, Lollis, Keith D, Paulsen   +7 more
openaire   +2 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Normalization of aberrant resting state functional connectivity in fibromyalgia patients following a three month physical exercise therapy

NeuroImage: Clinical, 2015
Physical exercise is one of the most efficient interventions to mitigate chronic pain symptoms in fibromyalgia (FM). However, little is known about the neurophysiological mechanisms mediating these effects.
P. Flodin, S. Martinsen, K. Mannerkorpi, M. Löfgren, I. Bileviciute-Ljungar, E. Kosek, P. Fransson   +6 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Genetically Increased Cell-Intrinsic Excitability Enhances Neuronal Integration into Adult Brain Circuits [PDF]

, 2009
New neurons are added to the adult brain throughout life, but only half ultimately integrate into existing circuits. Sensory experience is an important regulator of the selection of new neurons but it remains unknown whether experience provides specific ...
Okada, Masayoshi, Lin, Chia-Wei, Ainsworth, Alice, Kelsch, Wolfgang, Lois, Carlos, Sim, Shuyin   +5 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

The relation of ongoing brain activity, evoked neural responses, and cognition

Frontiers in Systems Neuroscience, 2010
Ongoing brain activity has been observed since the earliest neurophysiological recordings and is found over a wide range of temporal and spatial scales. It is characterized by remarkably large spontaneous modulations.
Sepideh Sadaghiani, Sepideh Sadaghiani, Sepideh Sadaghiani, Guido Hesselmann, Karl J Friston, Andreas Kleinschmidt, Andreas Kleinschmidt   +6 more
doaj   +1 more source

Dynamic Altered Amplitude of Low-Frequency Fluctuations in Patients With Major Depressive Disorder

Frontiers in Psychiatry, 2021
Background: Major depressive disorder (MDD) has demonstrated abnormalities of static intrinsic brain activity measured by amplitude of low-frequency fluctuation (ALFF).
Ruiping Zheng, Yuan Chen, Yu Jiang, Mengmeng Wen, Bingqian Zhou, Shuying Li, Yarui Wei, Zhengui Yang, Caihong Wang, Jingliang Cheng, Yong Zhang, Shaoqiang Han   +11 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source