Results 81 to 90 of about 8,419,741 (275)

Hierarchical disruption in the cortex of anesthetized monkeys as a new signature of consciousness loss

NeuroImage, 2021
Anesthesia induces a reconfiguration of the repertoire of functional brain states leading to a high function-structure similarity. However, it is unclear how these functional changes lead to loss of consciousness.
Camilo Miguel Signorelli, Lynn Uhrig, Morten Kringelbach, Bechir Jarraya, Gustavo Deco   +4 more
doaj   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Pattern classification of large-scale functional brain networks : identification of informative neuroimaging markers for epilepsy [PDF]

, 2012
The accurate prediction of general neuropsychiatric disorders, on an individual basis, using resting-state functional magnetic resonance imaging (fMRI) is a challenging task of great clinical significance.
GuangMing Lu, ZhengGe Wang, GuangMing Lu (164664), Cheng, Wei, Jie Zhang (64655), Zhang, ZhiQiang, Jie Zhang, Wang, ZhengGe, Jianfeng Feng (48703), ZhiQiang Zhang, Wei Cheng (52808), ZhengGe Wang (164658), Feng, Jianfeng, Wei Cheng, Jianfeng Feng, WenLian Lu (164662), WenLian Lu, ZhiQiang Zhang (164660), Zhang, Jie, Lu, Wenlian, Lu, GuangMing, Lu WenLian, Zhang ZhiQiang, Lu GuangMing, Feng Jianfeng, Zhang Jie, Cheng Wei, Wang ZhengGe   +27 more
core   +2 more sources

Intrinsic Brain Activity in Altered States of Consciousness [PDF]

Annals of the New York Academy of Sciences, 2008
Spontaneous brain activity has recently received increasing interest in the neuroimaging community. However, the value of resting‐state studies to a better understanding of brain–behavior relationships has been challenged. That altered states of consciousness are a privileged way to study the relationships between spontaneous brain activity and ...
Boly, Mélanie, Phillips, Christophe, Tshibanda, Luaba, Vanhaudenhuyse, Audrey, Schabus, M., Dang Vu, Thien Thanh, Moonen, Gustave, Hustinx, Roland, Maquet, Pierre, Laureys, Steven   +9 more
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Atlas of intrinsic timescales in the mouse brain

, 2023
Neural activity fluctuates over a wide range of timescales, which vary systematically across the forebrain. Differences in intrinsic timescales have been related to functional specialization and hierarchical organization of cortical areas and have been ...
Levina, A. ; https://orcid.org/, Shi, Y., Engel, T., Zeraati, R. ; https://orcid.org/, The International Brain Laboratory   +4 more
core  

Activity-dependent plasticity in visual forebrain areas of the zebra finch [PDF]

, 1996
Rollenhagen A, Bischof H-J. Activity-dependent plasticity in visual forebrain areas of the zebra finch. Behavioural Brain Research.
Rollenhagen, Astrid, Astrid Rollenhagen, Hans-Joachim Bischof, Bischof, Hans-Joachim   +3 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Patterned brain stimulation, what a framework with rhythmic and noisy components might tell us about recovery maximization

Frontiers in Human Neuroscience, 2013
Brain stimulation is having remarkable impact on clinical neurology. Brain stimulation can modulate neuronal activity in functionally segregated circumscribed regions of the human brain.
Sein eSchmidt, Michael eScholz, Klaus eObermayer, Stephan A Brandt   +3 more
doaj   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source