Results 111 to 120 of about 15,308,393 (377)

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

open access: yesMolecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson   +2 more
wiley   +1 more source

Cathepsin B Is Not an Intrinsic Factor Related to Asparaginase Resistance of the Acute Lymphoblastic Leukemia REH Cell Line. [PDF]

open access: yesInt J Mol Sci, 2023
Costa IM   +7 more
europepmc   +1 more source

Intrinsic and Extrinsic Motivation of English Education Graduation Students Batch 2018 in Accomplishing Academic Performance

open access: yesIdeas, 2019
This research is aimed to identify intrinsic and extrinsic motivation of graduate students in English Education Master Program batch 2018. However, motivation became the most dominant factor to build in relation to the academic performance.
Elizabeth Elizabeth, Ouda Teda Ena
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Line selection method with transient state based on intrinsic mode energy

open access: yesGong-kuang zidonghua, 2013
In view of problem that fault line selection method based on wavelet analysis of coal mine power grid ca't guarantee the optimal decomposition effect due to the decomposition effect depends on choice of primary function, the paper presented a fault line ...
WANG Qing-liang   +4 more
doaj   +1 more source

Bright end of the luminosity function of high-mass X-ray binaries: contributions of hard, soft and supersoft sources

open access: yes, 2016
Using a spectral analysis of bright Chandra X-ray sources located in 27 nearby galaxies and maps of star-formation rate (SFR) and ISM surface densities for these galaxies, we constructed the intrinsic X-ray luminosity function (XLF) of luminous high-mass
Khabibullin, Ildar, Sazonov, Sergey
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Home - About - Disclaimer - Privacy