Results 111 to 120 of about 15,038,588 (334)

Line selection method with transient state based on intrinsic mode energy

open access: yesGong-kuang zidonghua, 2013
In view of problem that fault line selection method based on wavelet analysis of coal mine power grid ca't guarantee the optimal decomposition effect due to the decomposition effect depends on choice of primary function, the paper presented a fault line ...
WANG Qing-liang   +4 more
doaj   +1 more source

Cathepsin B Is Not an Intrinsic Factor Related to Asparaginase Resistance of the Acute Lymphoblastic Leukemia REH Cell Line. [PDF]

open access: yesInt J Mol Sci, 2023
Costa IM   +7 more
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Preliminary Analysis on Environmental and Intrinsic Factors on FBG-Based Vibration Sensors

open access: diamond, 2021
Gaetano Quattrocchi   +3 more
openalex   +1 more source

Single photon emission and detection at the nanoscale utilizing semiconductor nanowires

open access: yes, 2008
We report recent progress toward on-chip single photon emission and detection in the near infrared utilizing semiconductor nanowires. Our single photon emitter is based on a single InAsP quantum dot embedded in a p-n junction defined along the growth ...
Algra, Rienk   +13 more
core   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Factor XI and XII inhibitors–Dawn of a new era

open access: yesIndian Heart Journal
The history of coagulation cascade dates back to 17th century. The extrinsic and intrinsic pathways were proposed in 1998. Extrinsic pathway includes the tissue factor and stable factor which activates factor X and with help of factor V, this converts ...
Chhabi Satpathy   +2 more
doaj   +1 more source

Novel intrinsic factor Yun maintains female germline stem cell fate through Thickveins. [PDF]

open access: yesStem Cell Reports, 2022
Zhao H   +6 more
europepmc   +1 more source

Key role for inhibins in effective T cell activation, migration and Th17 differentiation

open access: yesFEBS Open Bio, EarlyView.
Activins/inhibins modulate immune responses. Here, we show that inhibins can be produced very early after T cell activation and can act in an autocrine way, favoring Th1 versus Th17 differentiation and CCL19/CCL21 mediated migration. Recombinant inhibin A can restore the Th1/Th17 balance, highlighting the role of inhibins as key regulators of T cell ...
Sandra Ortega‐Francisco   +5 more
wiley   +1 more source

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