Results 141 to 150 of about 15,218,319 (382)

Pten is a key intrinsic factor regulating raphe 5-HT neuronal plasticity and depressive behaviors in mice. [PDF]

Transl Psychiatry, 2021
Chen L, Gong WK, Yang CP, Shao CC, Song NN, Chen JY, Zhou LQ, Zhang KS, Li S, Huang Z, Richter-Levin G, Xu L, Ding YQ.   +12 more
europepmc   +1 more source

Effect of maternal intrinsic factors on productivity and efficiency at weaning in commercial flock of Pelibuey ewes in the tropic of Tabasco, Mexico

, 2021
Alfonso Juventino Chay-Canúl, Julio Ramon-Ugalde, Darwin Nicolas Arcos-Álvarez, Roberto Zamora-Bustillos, Ricardo García‐Herrera, Ulises Macías‐Cruz, Ángel Trinidad Piñeiro-Vázquez   +6 more
openalex   +2 more sources

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Hematologic Responses and Concenrtation of Vitamin B12 in Serum and Urine following Oral Administration of Vitamin B12 without Intrinsic Factor [PDF]

, 1954
G. I. M. Ross, D. L. Mollin, E. V. Cox, C. C. Ungley   +3 more
openalex   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Functional genomic landscape of cancer-intrinsic evasion of killing by T cells

Nature, 2020
K. Lawson, C. Sousa, Xiaoyu Zhang, Eiru Kim, Rummy Akthar, Joseph J. Caumanns, Yuxi Yao, N. Mikolajewicz, Catherine Ross, K. Brown, Abdelrahman Abou Zid, Z. Fan, Shirley Hui, Jordan A. Krall, D. M. Simons, Chloe J. Slater, V. D. de Jesus, Lujia Tang, Richa Singh, J. Goldford, Sarah Martin, Qian Huang, E. A. Francis, Andrea Habsid, Ryan Climie, D. Tieu, Jiarun Wei, Ren Li, A. Tong, Michael Aregger, Katherine Chan, H. Han, Xiaowei Wang, P. Mero, J. Brumell, A. Finelli, L. Ailles, Gary D Bader, Gromoslaw A. Smolen, G. Kingsbury, Traver Hart, C. Kung, J. Moffat   +42 more
semanticscholar   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Assessing the Impact of Herzberg’s Two-Factor Motivation Theory on Job Satisfaction: A Study of Employees in the Punjab Healthcare Commission

Sustainable Business and Society in Emerging Economies
Herzberg’s Two-Factor Motivation Theory provides a critical framework for understanding job satisfaction by distinguishing between intrinsic motivators and extrinsic hygiene factors.
Haider Jaffar, Aamir Jawad Munir, Malik Muhammad Waqas   +2 more
doaj   +1 more source