Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Does Green-Person-Organization Fit Predict Intrinsic Need Satisfaction and Workplace Engagement?
Frontiers in Psychology, 2019 The current study assessed whether high green-person-organization fit (GPO; the extent to which an organization’s commitment to pro-environmental outcomes is congruent with its employees’ environmental values) predicts employees’ intrinsic need ...
Carol Hicklenton +2 more
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Negative oxygen vacancies in HfO$_2$ as charge traps in high-k stacks
, 2006 We calculated the optical excitation and thermal ionization energies of oxygen vacancies in m-HfO$_2$ using atomic basis sets, a non-local density functional and periodic supercell. The thermal ionization energies of negatively charged V$^-$ and V$^{2-}$
A. L. Shluger +6 more
core +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Age-specific growth, reproductive values, and intrinsic r
Demographic Research, 2011 The age-specific growth function of an observed population and the reproductive value function based on the population's current vital rates determine the intrinsic rate of growth implied by those vital rates through the simple relationship given in
Robert Schoen
doaj
The interplay of work values, job satisfaction and intention to stay among millennials in Indonesia
Cogent Business & ManagementThis study aims to investigate the relationship between work values (intrinsic and extrinsic), job satisfaction and intention to stay among millennial employees in Indonesia.
Yuniadi Mayowan +3 more
doaj +1 more source
"I Climbed a Fig Tree, on an Apple Bashing Spree, Only Pears Fell Free": Economic, Symbolic and Intrinsic Values of Plants Occurring in Slovenian Folk Songs Collected by K. Štrekelj (1895-1912). [PDF]
Plants (Basel), 2022 Fišer Ž.
europepmc +1 more source
Revisiting the Light Cone of the Goedel Universe
, 2005 The structure of a light cone in the Goedel universe is studied. We derive the intrinsic cone metric, calculate the rotation coefficients of the ray congruence forming the cone, determine local differential invariants up to second order, describe the ...
Abdel-Megied, M., Dautcourt, G.
core +2 more sources