Results 101 to 110 of about 15,642,647 (329)

The Neuroscience of Growth Mindset and Intrinsic Motivation

open access: yesBrain Science, 2018
Our actions can be triggered by intentions, incentives or intrinsic values. Recent neuroscientific research has yielded some results about the growth mindset and intrinsic motivation. With the advances in neuroscience and motivational studies, there is a
B. Ng
semanticscholar   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

AN ANALYSIS OF THE INTRINSIC ELEMENTS AND MORAL VALUES IN TETSUKO KUROYANAGI’S NOVEL ‘’TOTTO CHAN: THE LITTLE GIRL AT THE WINDOW’’

open access: yesEnglish Community Journal, 2017
The objectives of this research were to find out the intrinsic elements and the moral values in Totto Chan: the Little Girl at the Window novel. This research employed descriptive qualitative as the method.
Ardayati Ardayati, Asih Rahayu
doaj  

Workplace Spirituality and Job Satisfaction: Moderating Role Of Intrinsic and Extrinsic Values

open access: yesInternational journal of management research and emerging sciences, 2015
Workplace spirituality has gained attention of researchers in last two decades. Material investment is no more considered to be an enough ingredient towards getting desired outcomes from the employees.
Tasneem Fatima   +3 more
semanticscholar   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Heuristic quantization of the cranking model

open access: yes, 1996
We propose a simple and systematic method to quantize the cranking model and to calculate the matrix elements of intrinsic operators entering the generalized intensity relations.
Nakatsukasa, Takashi   +1 more
core   +2 more sources

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Les valeurs de la nature dans les iles subantarctiques

open access: yesVertigO, 2019
This article explores the values attributed to nature and how they are articulated in a particular territory, the French sub-Antarctic islands. Since these islands do not have permanent populations and are not exploited for their biological or mining ...
Anne Atlan, Véronique Van Tilbeurgh
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

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