Results 31 to 40 of about 720,430 (259)

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Values in Narratives: Religious Education as an Exercise in Emotional Rationality

open access: yesReligions
The domain of education deals with the issue of the possibility of a person’s development so that the person would learn to become more human through the educational process.
Ivan Dodlek
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Social values for biodiversity and carbon flow in cities

open access: yesPeople and Nature
Urban green areas contribute to climate change mitigation, support biodiversity and host a wide range of social values important for urban residents. Understanding the interplay between social values, biodiversity and carbon flow in urban green areas is ...
Jussi Lampinen   +6 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Relational values resonate broadly and differently than intrinsic or instrumental values, or the New Ecological Paradigm.

open access: yesPLoS ONE, 2017
Value orientations used to explain or justify conservation have been rooted in arguments about how much and in what context to emphasize the intrinsic versus instrumental value of nature.
Sarah C Klain   +3 more
doaj   +1 more source

Exploring intrinsic, instrumental, and relational values for sustainable management of social-ecological systems

open access: yesEcology and Society, 2017
The values (i.e., importance) that people place on ecosystems have been identified as a crucial dimension of sustainable management of social-ecological systems.
Paola Arias-Arévalo   +2 more
doaj   +1 more source

Pharmacists' perceptions of pharmacy technician occupational values

open access: yesExploratory Research in Clinical and Social Pharmacy, 2023
Background: Pharmacy technician scope of practice has expanded in recent years to attempt to alleviate the responsibility burden placed on pharmacists in some states. However, little research has examined the ways in which pharmacists attempt to persuade
Wesley Sparkmon   +6 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

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