Results 291 to 300 of about 7,902,914 (332)

The Intrinsic Disordered N-Terminus of Nucleocapsid Protein of SARS-CoV-2 Is Critical in DNA Aptamer Binding. [PDF]

Int J Mol Sci
Lu H, Ma J, Ma X, Wu Y, Sun X, Ma C, Li X, Xu Z, Lu P, Luo Z, Zhang L, Zhang L, Wang S.   +12 more
europepmc   +1 more source

Conserved C-terminal residues adjacent to the canonical PDX1 homeodomain are required for chromatin occupancy and pancreas development. [PDF]

Development
Wokasch AS, Shamoon M, Campbell C, Wu T, Fuhr JD, Gilbert A, Mehaffey T, Barnes CM, Ahuja N, Gingerich MA, Zhu J, Gadue P, Cleaver O, Mchaourab H, Stoffers DA, Soleimanpour SA, Gannon M.   +16 more
europepmc   +1 more source

How a Highly Acidic SH3 Domain Binds to Its Intrinsically Disordered Partner through the Formation of an Encounter Complex Intermediate. [PDF]

J Phys Chem B
Jaramillo-Martinez V, Kukreja R, Cohen MR, Mujica A, Barton S, Onwuzulu OC, Cardoso J, Dominguez MJ, Kekwick IM, Ali J, Bell GM, Rice S, Poaquiza D, McClure C, Anguiano F, Latham MP, Ball KA, Stollar EJ.   +17 more
europepmc   +1 more source

RIBEX: predicting and explaining RNA binding across structured and intrinsically disordered regions (IDR)-rich proteins. [PDF]

Bioinformatics
Firmani S, Steinbauer F, Kasneci G, Marsico A, Horlacher M.   +4 more
europepmc   +1 more source

Intrinsically Disordered Proteins and Proteins With Intrinsically Disordered Regions in Neurodegenerative Diseases

Biophysical Reviews, 2022
Many different intrinsically disordered proteins and proteins with intrinsically disordered regions are associated with neurodegenerative diseases. These types of proteins including amyloid-β, tau, α-synuclein, CHCHD2, CHCHD10, and G-protein coupled receptors are increasingly becoming evaluated as potential drug targets in the pharmaceutical-based ...
Orkide Coşkuner-Weber, Vladimir Uversky
exaly   +5 more sources

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A Comprehensive Review and Comparison of Existing Computational Methods for Intrinsically Disordered Protein and Region Prediction.

Briefings in Bioinformatics, 2019
Xiaolong Wang, Bin Liu, Liu Yumeng
exaly   +2 more sources

Classification of Intrinsically Disordered Regions and Proteins

Chemical Reviews, 2014
1.1. Uncharacterized Protein Segments Are a Source of Functional Novelty Over the past decade, we have observed a massive increase in the amount of information describing protein sequences from a variety of organisms.1,2 While this may reflect the diversity in sequence space, and possibly also in function space,3 a large proportion of the sequences ...
Benjamin Lang, Robin van der Lee, Peter Tompa   +2 more
exaly   +6 more sources

Intrinsically Disordered Proteins/Regions and Insight Into Their Biomolecular Interactions

Biophysical Chemistry, 2022
Proteins may vary from being rigid to having flexible regions to being completely disordered, either as an intrinsically disordered protein (IDP) or having specific intrinsically disordered regions (IDRs). IDPs/IDRs can form complexes otherwise impossible, such as wrapping around the binding partner, hence providing the plasticity needed for achieving ...
Pinak Chakrabarti, Devlina Chakravarty
exaly   +3 more sources