Results 281 to 290 of about 7,902,914 (332)

The Conservation and Classification of Intrinsically Disordered Regions in Proteins

, 2014
openaire   +1 more source

AI‐Powered, Temperature‐Resolved Centrifugal Microfluidics for Rapid 3D Phase‐Diagram Generation of Biomolecular Condensates

Advanced Science, EarlyView.
By merging centrifugal microfluidics, precise temperature control, and AI image recognition, T‐PhaseMap transforms biomolecular condensate phase mapping into a rapid, temperature‐resolved workflow. It generates 3D composition–temperature phase diagrams within 30 min, resolves four phase states, and uncovers temperature‐dependent heparin sodium ...
Jiashuo Li, Pengjie Li, Kaiting Zhang, Yongqi Guo, Peng Chen, Bi‐Feng Liu, Yiwei Li   +6 more
wiley   +1 more source

Sequence-encoded determinants drive distinct early aggregation pathways and different structural outcomes in PNT1 fibrils across Henipavirus members. [PDF]

Protein Sci
Sawdekar H, Mignon J, Gondelaud F, Walimbe A, Mukhopadhyay S, Chamieh J, Longhi S.   +6 more
europepmc   +1 more source

AHR‐Responsive Carbon Dots Orchestrate Skin Wound Healing and Colonic Mucosal Repair via Treg‐Mediated Macrophage Efferocytosis

Advanced Science, EarlyView.
Guided by pharmacophore modeling and molecular docking, aryl hydrocarbon receptor (AHR)‐responsive carbon dots were synthesized. They bind directly to AHR and expand gut‐resident regulatory T (Treg) cells. Treg‐derived C‐C motif chemokine ligand 1 (CCL1) enhances macrophage efferocytosis, creating a pro‐regenetative niche that promotes colonic mucosal ...
Zilu Zhu, Han Zhang, Shuai Lin, Wenqian Zheng, Xin Li, Xiaowei Xu, Ruili Yang   +6 more
wiley   +1 more source

Structuring Disorder via Supervised Molecular Dynamics: Uncovering Arginine-Glycine-Glycine-Mediated Ribonucleic Acid-Intrinsically Disordered Region Recognition Mechanisms. [PDF]

J Chem Inf Model
Novello G, Dodaro A, Strascia CC, Menin S, Sturlese M, Salmaso V, Moro S.   +6 more
europepmc   +1 more source

Single‐Molecule Imaging of Endogenous RNA Using a Miniaturized and Circularly Permuted CRISPR‐Cas13 Degron‐Masking System CDegSR

Advanced Science, EarlyView.
CDegSR, a new tool for imaging RNA at single molecule level in living cells was developed by researchers. Background noise was eliminated by protein engineering and making it degrade when not bound to its target. This allowed individual RNA molecules to be clearly imaged and tracked.
Shipeng Shao, Hongchen Zhang
wiley   +1 more source

Intrinsically disordered regions facilitate Mlp1-Nab2 recognition in mRNA quality control. [PDF]

Nucleus
Soheilypour M, Peyro M, Shams H, Mofrad MRK.   +3 more
europepmc   +1 more source

Targeting LDHA Palmitoylation Sensitizes GBM to Chemoradiotherapy via Suppressing Palmitic Acid Induced Glycolytic Reprogramming

Advanced Science, EarlyView.
Mesenchymal GSCs preferentially uptake palmitic acid, thereby promoting ZDHHC12‐mediated LDHA palmitoylation. This modification enhances LDHA enzymatic activity, drives glycolytic reprogramming, and facilitates exosomal LDHA‐mediated TAM regulation.
Zijie Gao, Rongrong Zhao, Zheyuan Chen, Qingtong Wang, Huanyu Yang, Boyan Li, Yanhua Qi, Shulin Zhao, Jixing Zhao, Jiawei Qiu, Ziwen Pan, Zhe Han, Ruochuan Li, Huize Xia, Weijie Tang, Xing Guo, Ping Zhang, Hongyu Zhao, Xu Qian, Gang Li, Hao Xue   +20 more
wiley   +1 more source

Conformational stability and domain-specific structural features of tumor autoantigens regulate autoantibody epitope propensity. [PDF]

Protein Sci
Miyamoto A, Yamamoto R, Sakaguchi R, Kutsuma R, Mori T, Masui M, Honjo T, Futami M, Morii M, Watanabe H, Kuribayashi T, Ohashi K, Kiura K, Futami J.   +13 more
europepmc   +1 more source

Menke-Hennekam Syndrome as a Domain-Resolved Disorder of the Transcriptional Coactivators CBP and p300. [PDF]

Genes (Basel)
Sanoudou D, Anastasiou AM, Eliopoulos AG.   +2 more
europepmc   +1 more source