Results 281 to 290 of about 29,703 (304)
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Journal of Structural Biology, 2020
Intrinsically disordered proteins (IDPs) are crucial players in various cellular activities. Several experimental and computational analyses have been conducted to study structural pliability and functional potential of IDPs. In spite of active research in past few decades, what induces structural disorder in IDPs and how is still elusive. Many studies
Sushmita, Basu, Ranjit Prasad, Bahadur
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Intrinsically disordered proteins (IDPs) are crucial players in various cellular activities. Several experimental and computational analyses have been conducted to study structural pliability and functional potential of IDPs. In spite of active research in past few decades, what induces structural disorder in IDPs and how is still elusive. Many studies
Sushmita, Basu, Ranjit Prasad, Bahadur
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Role of intrinsically disordered protein regions/domains in transcriptional regulation
Life Sciences, 2009In recent years, it has become quite evident that numerous proteins exist as an ensemble of conformers that collectively appears to be intrinsically disordered (ID). Of particular significance is the growing body of evidence that intrinsic disorder is found in disproportionately higher amounts in cell signaling proteins and transcription factors ...
Anna S, Garza, Nihal, Ahmad, Raj, Kumar
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Archives of Biochemistry and Biophysics
In the early 2000s, the concept of "unstructured biology" has emerged to be an important field in protein science by generating various new research directions. Many novel strategies and methods have been developed that are focused on effectively identifying/predicting intrinsically disordered proteins (IDPs) and intrinsically disordered protein ...
Bondeepa Saikia, Anupaul Baruah
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In the early 2000s, the concept of "unstructured biology" has emerged to be an important field in protein science by generating various new research directions. Many novel strategies and methods have been developed that are focused on effectively identifying/predicting intrinsically disordered proteins (IDPs) and intrinsically disordered protein ...
Bondeepa Saikia, Anupaul Baruah
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Functional roles of transiently and intrinsically disordered regions within proteins
The FEBS Journal, 2015Proteins are structurally heterogeneous and comprise folded regions with variable conformational stabilities and intrinsically disordered protein regions that do not have well‐folded structures. Even small, well‐folded single‐domain proteins are structurally heterogeneous and contain multiple foldon units with different conformational stability ...
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Nanoassembly of spider silk protein mediated by intrinsically disordered regions
International Journal of Biological MacromoleculesSpider silk is the self-assembling product of silk proteins each containing multiple repeating units. Each repeating unit is entirely intrinsically disordered or contains a small disordered domain. The role of the disordered domain/unit in conferring silk protein storage and self-assembly is not fully understood yet.
Jiaxin, Li +6 more
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Intrinsically disordered regions as affinity tuners in protein–DNA interactions
Molecular BioSystems, 2011Abstract Intrinsically disordered regions, terminal tails, and flexible linkers are abundant in DNA-binding proteins and play a crucial role by increasing the affinity and specificity of DNA binding. Disordered tails often undergo a disorder-to-order transition during interactions with DNA and improve both the kinetics and ...
Dana, Vuzman, Yaakov, Levy
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Remote on–off switching of protein activity by intrinsically disordered region
Nature Structural & Molecular BiologyWhile the regulation of protein function theoretically encompasses alterations in both structural conformation and dynamic properties, the latter aspect, specifically conformational entropy, remains relatively unexplored. Here we show that an intrinsically disordered region (IDR), a prominent component of the proteome, can remotely switch protein ...
Tuo Ji +11 more
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Intrinsically disordered Meningioma-1 stabilizes the BAF complex to cause AML
Molecular Cell, 2021Simone S Riedel +2 more
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