Results 241 to 250 of about 66,315 (318)

Scale-free Spatio-temporal Correlations in Conformational Fluctuations of Intrinsically Disordered Proteins. [PDF]

Adv Sci (Weinh)
Song H, Cui J, Hu G, Xiong L, Wutthinitikornkit Y, Lei H, Li J.   +6 more
europepmc   +1 more source

Intrinsic disorder in the C-terminal domain of the Shaker voltage-activated K ⁺ channel modulates its interaction with scaffold proteins

, 2007
Elhanan Magidovich, Irit Orr, Deborah Fass, Uri Abdu, Ofer Yifrach   +4 more
openalex   +1 more source

Vm–MSI: a Vancomycin–Antimicrobial Peptide Conjugate Combating Resistant Bacteria and Broadening the Antimicrobial Spectrum

Advanced Science, EarlyView.
A series of vancomycin‐antimicrobial peptide conjugates is synthesized and evaluated to identify the optimal combination. Vm‐MSI, selected from multiple candidates, exhibited potent activity against vancomycin‐resistant and Gram‐negative bacteria by disrupting membranes and inducing oxidative stress, thereby expanding vancomycin's antibacterial ...
Shuangyu Li, Kang Wang, Wenzhuang Shi, Xu Wang, Duxin Li, Yanli Liu, Peng Zhang, Yipeng Wang   +7 more
wiley   +1 more source

Successful prediction of LC8 binding to intrinsically disordered proteins sheds light on AlphaFold's black box. [PDF]

Front Mol Biosci
Walker DR, Fujimura G, Vanegas JM, Barbar EJ.   +3 more
europepmc   +1 more source

EIF1AX Nucleolar Condensates Enhance Susceptibilities for the Management of Endometrial Cancer

Advanced Science, EarlyView.
This schematic illustrates the mechanism of a senolytic strategy in endometrial cancer. EIF1AX facilitates the incorporation of DDX21 into nucleolar condensates, an event that suppresses rDNA transcription and induces cellular senescence. The compound 2,5‐MeC exploits this pathway by promoting EIF1AX nucleolar translocation and condensate formation ...
Chengyu Lv, Zihang Lin, Jiandong Sun, Yuhong Ye, Qibin Wu, Liangzhi Cai, Dabin Liu, Pengming Sun, Shie Wang   +8 more
wiley   +1 more source

Dynamical buffering of reconfiguration dynamics in intrinsically disordered proteins

Ivanović MT, Holla A, Nüesch MF, von Roten V, Schuler B, Best RB.   +5 more
europepmc   +1 more source

Landscape of intrinsically disordered proteins in mental disorder diseases. [PDF]

Comput Struct Biotechnol J
Zhang X, Song X, Hu G, Yang Y, Liu R, Zhou N, Basu S, Qiao D, Hou Q.   +8 more
europepmc   +1 more source

Modifying Glucose Metabolism Reverses Memory Defects of Alzheimer's Disease Model at Late Stages

Advanced Science, EarlyView.
Using spatial transcriptomics, we show that ferul enanthate (SL‐ZF‐01) reverses episodic‐like memory deficits in aged, but not young, Alzheimer’s disease (AD) mice. SL restores glucose metabolism and Glucose Transporter 1/3 expression via an ‘Aging‐AD‐Rescue’ pattern, rescuing deficits seen in aged AD mice.
Fang Liu, Yiyu‐Li Tang, Zong‐Bo Zhang, Ya‐Hong Tan, Si‐Hui Lin, Ni‐Ya Wang, Jin‐Nan Li, Zhi‐Jie Pan, Jian‐Feng Li, Jing‐Fei Huang, Yu‐Qiang Ding, Chun‐Ming Guo, Lin Xu, Cheng Peng, Qi‐Xin Zhou   +14 more
wiley   +1 more source

2P093 Heme binding region of Bach2 as intrinsically disordered protein(02. Heme proteins,Poster)

, 2013
Kazutaka Murayama, Miki Matsui, Kazuhiko Igarashi   +2 more
openalex   +2 more sources

Vitamin D Regulates Olfactory Function via Dual Transcriptional and mTOR‐Dependent Translational Control of Synaptic Proteins

Advanced Science, EarlyView.
Vitamin D (VitD) modulates olfactory function by remodeling dendrodendritic synapses in tufted cells through vitamin D receptor‐dependent transcriptional and translational mechanisms. VitD regulates synaptic protein translation partially via mTOR signaling.
Pengcheng Ren, Renhe Cao, Xiaoshan Ye, Wenbin Pang, Qingshang Bi, Meihui Huang, Qionglin Zhou, Dan Ye, Wei Xiang, Le Xiao   +9 more
wiley   +1 more source