Results 261 to 270 of about 40,484 (286)

Druggability of Intrinsically Disordered Proteins

2015
Although the proteins in all the current major classes considered to be druggable are folded in their native states, intrinsically disordered proteins (IDPs) are becoming attractive candidates for therapeutic intervention by small drug-like molecules.
Priyanka, Joshi, Michele, Vendruscolo
openaire   +2 more sources

Exploring Protein Intrinsic Disorder with MobiDB

2020
Nowadays, it is well established that many proteins or regions under physiological conditions lack a fixed three-dimensional structure and are intrinsically disordered. MobiDB is the main repository of protein disorder and mobility annotations, combining different data sources to provide an exhaustive overview of intrinsic disorder.
Monzon A. M., Hatos A., Necci M., Piovesan D., Tosatto S. C. E.   +4 more
openaire   +2 more sources

A Frustrated Binding Interface for Intrinsically Disordered Proteins

Journal of Biological Chemistry, 2014
Background: Protein-protein interactions often involve intrinsically disordered protein domains. Results: The binding interface between two disordered protein domains is suboptimal, or frustrated, with regard to the energetics.
Per Jemth, Xin Mu, Åke Engstrom
exaly   +2 more sources

Intrinsic Disorder and Protein Function

Biochemistry, 2002
A Keith, Dunker, Celeste J, Brown, J David, Lawson, Lilia M, Iakoucheva, Zoran, Obradović   +4 more
openaire   +2 more sources

Intrinsically disordered proteins

This chapter explores intrinsically disordered proteins (IDPs), detailing their discovery, structural characteristics, and indispensable biological functions. It introduces the hypothesis that unfolded proteins can bind diverse partners, first proposed in 1939, and follows the experimental validation of IDPs using NMR and X-ray methods.
openaire   +2 more sources

Current Challenges and Limitations in the Studies of Intrinsically Disordered Proteins in Neurodegenerative Diseases by Computer Simulations

Current Alzheimer Research, 2021
Vladimir N Uversky, Orkid Coskuner-Weber   +1 more
exaly  

Intrinsically disordered proteins and biomolecular condensates as drug targets

Current Opinion in Chemical Biology, 2021
Mateusz Biesaga, Marta Frigolé-Vivas, Xavier Salvatella   +2 more
exaly  

Intrinsically disordered proteins in cellular signalling and regulation

Nature Reviews Molecular Cell Biology, 2014
Peter E Wright, H Jane Dyson, Wright Peter E   +2 more
exaly  

Tardigrades Use Intrinsically Disordered Proteins to Survive Desiccation

Molecular Cell, 2017
Thomas C Boothby, Hugo Tapia, Samantha Piszkiewicz   +2 more
exaly  

NMR Spectroscopic Studies of Intrinsically Disordered Proteins at Near‐Physiological Conditions

Angewandte Chemie - International Edition, 2013
Tomáš Hosek, Zsófia Sólyom, Rainer Kümmerle   +2 more
exaly