Results 271 to 280 of about 66,315 (318)

MOBIDB in 2025: integrating ensemble properties and function annotations for intrinsically disordered proteins. [PDF]

Nucleic Acids Res
Piovesan D, Del Conte A, Mehdiabadi M, Aspromonte MC, Blum M, Tesei G, von Bülow S, Lindorff-Larsen K, Tosatto SCE.   +8 more
europepmc   +1 more source

Design of intrinsically disordered region binding proteins

Kejia Wu, Hanlun Jiang, Derrick R. Hicks, Caixuan Liu, Edin Muratspahić, Theresa A. Ramelot, Yuexuan Liu, Kerrie E. McNally, Sebastian Kenny, Andrei Mihut, Amit Gaur, Brian Coventry, Wei Chen, Asim K. Bera, Alex Kang, Analisa Murray, Xinting Li, Analisa Murray, Xinting Li, Madison Kennedy, Wei Yang, Zihao Song, Gudrun Schober, Stuart M. Brierley, David Baker, Michael H. Gelb, G.T. Montelione, Emmanuel Derivery, David Baker   +28 more
openalex   +2 more sources

Wedelolactone, a Novel TLR2 Agonist, Promotes Neutrophil Differentiation and Ameliorates Neutropenia: A Multi‐Omics Approach to Unravel the Mechanism

Advanced Science, EarlyView.
Wedelolactone (WED), a natural TLR2 agonist, promotes neutrophil differentiation and enhances bactericidal function, offering a potential therapeutic strategy for neutropenia. Using a multi‐omics approach, this study reveals that WED activates the TLR2/MEK/ERK pathway, upregulating key transcription factors (PU.1, CEBPβ) to drive neutrophil development.
Long Wang, Zhichao Li, Tianci Hu, Qinyao Li, Linwei Zhang, Xinyue Mei, Xiao Qi, Sheng Liu, Weijie Kong, Jiesi Luo, Anguo Wu, Feihong Huang, Sirui Li, Shuang Dai, Chunxiang Zhang, Rong Li, Jianming Wu   +16 more
wiley   +1 more source

Intrinsic stiffness and Θ-solvent regime in intrinsically disordered proteins: Implications for liquid-liquid phase separation. [PDF]

PNAS Nexus
Baidya L, Kremer K, Reddy G.
europepmc   +1 more source

Burn‐Safe Biodegradable Magnetocaloric Composites for Temperature‐Controlled Biomedical Applications

Advanced Science, EarlyView.
This work investigates a magnetocaloric (Mn,Fe)2(P,Si) compound tailored for precise, self‐regulating heating in biomedical use. With a Curie temperature tuned at 43 °C, it enables therapeutic activation without overheating. Encapsulation in a composite ensures controlled temperature rise under an alternating magnetic field (AMF), with high ...
Pornpawee Uliss, Vasiliki Gkouzioti, Wuliji Hanggai, Friso Kahler, Elena Aprea, Qi Jia, Jean‐Philippe Frimat, Ekkes Brück, Clementine M. Boutry   +8 more
wiley   +1 more source

A genetically encoded anomalous SAXS ruler to probe the dimensions of intrinsically disordered proteins. [PDF]

Proc Natl Acad Sci U S A
Yu M, Gruzinov AY, Ruan H, Scheidt T, Chowdhury A, Giofrè S, Mohammed ASA, Caria J, Sauter PF, Svergun DI, Lemke EA.   +10 more
europepmc   +1 more source

TBK1 Induces the Formation of Optineurin Filaments That Condensate with Polyubiquitin and LC3 for Cargo Sequestration

Advanced Science, EarlyView.
Phosphorylation of Optineurin by TBK1 induces the formation of filaments that condensate upon binding to linear polyubiquitin. Membrane‐anchored LC3 partitions into these condensates, suggesting that phase separation of filamentous Optineurin with ubiquitylated cargo promotes the sequestration of cargo and its subsequent alignment with LC3‐positive ...
Maria G. Herrera, Lena Kühn, Lisa Jungbluth, Verian Bader, Laura J. Krause, David Kartte, Elias Adriaenssens, Sascha Martens, Jörg Tatzelt, Carsten Sachse, Konstanze F. Winklhofer   +10 more
wiley   +1 more source

Deeper Insight of the Conformational Ensemble of Intrinsically Disordered Proteins. [PDF]

J Chem Inf Model
Svensson O, Bakker MJ, Skepö M.
europepmc   +1 more source

Effect of Water–DMSOBinary Solvent Mixtureon the Behavior of an Intrinsically Disordered Protein, β‑Casein

Saurabh Rai (11210346), Debanggana Shil (16623931), Bijan Kumar Paul (2157481), Saptarshi Mukherjee (1290723)   +3 more
openalex   +1 more source

Wearable and Implantable Devices for Continuous Monitoring of Muscle Physiological Activity: A Review

Advanced Science, EarlyView.
Recent advances in materials and device engineering enable continuous, real‐time monitoring of muscle activity via wearable and implantable systems. This review critically summarizes emerging technologies for tracking electrophysiological, biomechanical, and oxygenation signals, outlines fundamental principles, and highlights key challenges and ...
Zhengwei Liao, Ata Golparvar, Mohammad Javad Bathaei, Filipe Arroyo Cardoso, Clementine M. Boutry   +4 more
wiley   +1 more source