Results 281 to 290 of about 448,472 (368)

Dissecting the biophysics and biology of intrinsically disordered proteins. [PDF]

Trends Biochem Sci
Banerjee PR, Holehouse AS, Kriwacki R, Robustelli P, Jiang H, Sobolevsky AI, Hurley JM, Mendell JT.   +7 more
europepmc   +1 more source

Markov Models of Amino Acid Substitution to Study Proteins with Intrinsically Disordered Regions

, 2011
Adam M. Szalkowski, Maria Anisimova
openalex   +2 more sources

COPS5 Triggers Ferroptosis Defense by Stabilizing MK2 in Hepatocellular Carcinoma

Advanced Science, EarlyView.
COPS5, which is overexpressed in HCC in an amplification‐ and ATF4‐dependent manner, stabilizes MK2 through deubiquitination and, in turn, induces HSPB1 activation, protecting HCC cells from ferroptosis and thus promoting sorafenib resistance and tumor progression. Abstract Sorafenib, which is proven to serve as a potent ferroptosis inducer, is used as
Ai‐Ling Luo, Wen‐Ying Zheng, Qiong Zhang, Yan Yuan, Mei‐Qi Li, Kai Du, An‐Ran Gao, Li‐Jun Pei, Jie Xie, Wen‐Hao Chen, Long Zhang, Xiu‐Zhu Guo, Xiao‐Ran Yang, Chao Zeng, Guo‐Hua Yang, Min Deng   +15 more
wiley   +1 more source

Intrinsic disorder in the common N-terminus of human adenovirus 5 E1B-55K and its related E1BN proteins indicated by studies on E1B-93R

, 2011
Timo Sieber, Roland W. Scholz, Michael Spoerner, Frank Schumann, Hans Robert Kalbitzer, Thomas Dobner   +5 more
openalex   +1 more source

S‐ketamine Alleviates Neuroinflammation and Attenuates Lipopolysaccharide‐Induced Depression Via Targeting SIRT2

Advanced Science, EarlyView.
S‐ketamine binds directly to SIRT2, facilitating its interaction with NF‐κB p65. This interaction reduces the acetylation of NF‐κB p65 and inhibits its activation, thereby exerting anti‐inflammatory and antidepressant effects. Created by BioRender.
Cong Lin, Xiaoxuan Zhou, Mingqi Li, Cong Zhang, Haojiang Zhai, Haohong Li, Hongshuang Wang, Xiaohui Wang   +7 more
wiley   +1 more source

Best practices for the manual curation of intrinsically disordered proteins in DisProt. [PDF]

Database (Oxford)
Quaglia F, Chasapi A, Nugnes MV, Aspromonte MC, Leonardi E, Piovesan D, Tosatto SCE.   +6 more
europepmc   +1 more source

Engineered Probiotics Mitigate Gut Barrier Dysfunction Induced by Nanoplastics

Advanced Science, EarlyView.
Intestinal barrier stability is vital for gut health. Plastic polyethylene terephthalate (PET) disrupts this barrier, causing inflammation and infections. This study encodes transforming growth factor‐β into EcN and modifies its surface with pH‐responsive polymer (EcNT@L), creating an oral drug delivery system to repair nano PET‐induced intestinal ...
Wenxin Chen, Qiyan Guo, Hong Li, Xue Chi, Xiang Ma, Yanqiong Tang, Quanfeng Liang, Zhu Liu, Yong Liu, Juanjuan Li   +9 more
wiley   +1 more source

Map conformational landscapes of intrinsically disordered proteins with polymer physics quantities. [PDF]

Biophys J
Shadman H, Ziebarth JD, Gallops CE, Luo R, Li Z, Chen HF, Wang Y.   +6 more
europepmc   +1 more source

Aqueous Two‐Phase Submicron Droplets Catalyze DNA Nanostructure Assembly for Confined Fluorescent Biosensing

Advanced Science, EarlyView.
Submicron droplets, formed by a polyethyleneglycol (PEG)/dextran aqueous two‐phase system·(ATPS), can act as catalytic centers that concentrate DNA and accelerate assembly kinetic in crowded environments. It highlights a cooperative mechanism wherein global crowding from PEG induces an excluded volume effect, while local crowding from dextran provides ...
Xiaoman Duan, Siyi Duan, Zhaoyu Han, Haoyue Lv, Haozhen Yu, Biwu Liu   +5 more
wiley   +1 more source

Streamlining NMR Chemical Shift Predictions for Intrinsically Disordered Proteins: Design of Ensembles with Dimensionality Reduction and Clustering. [PDF]

J Chem Inf Model
Bakker MJ, Gaffour A, Juhás M, Zapletal V, Stošek J, Bratholm LA, Pavlíková Přecechtělová J.   +6 more
europepmc   +1 more source