Results 221 to 230 of about 2,589,108 (245)

Intrinsically disordered regions regulate RhlE RNA helicase functions in bacteria. [PDF]

Nucleic Acids Res
Hausmann S, Geiser J, Allen GE, Geslain SAM, Valentini M.   +4 more
europepmc   +1 more source

Intrinsically disordered regions (IDRs): A vague and confusing concept for protein function. [PDF]

Mol Cell
Struhl K.
europepmc   +1 more source

Evolution of Virus-like Features and Intrinsically Disordered Regions in Retrotransposon-derived Mammalian Genes. [PDF]

Mol Biol Evol
Cagliani R, Forni D, Mozzi A, Fuchs R, Tussia-Cohen D, Arrigoni F, Pozzoli U, De Gioia L, Hagai T, Sironi M.   +9 more
europepmc   +1 more source

Evolutionary analyses of intrinsically disordered regions reveal widespread signals of conservation. [PDF]

PLoS Comput Biol
Singleton MD, Eisen MB.
europepmc   +1 more source

Oligomerization enables the selective targeting of intrinsically disordered regions by small molecules

Bielskutė S, Mateos B, Awawdy M, Garcia-Cabau C, Niskanen H, Sánchez-Zarzalejo C, Bracaglia L, Pierattelli R, Felli IC, Frigolé-Vivas M, García J, Riera A, Hnisz D, Salvatella X.   +13 more
europepmc   +1 more source

Intrinsically disordered proteins and structured proteins with intrinsically disordered regions have different functional roles in the cell [PDF]

PLoS ONE, 2019
Many studies about classification and the functional annotation of intrinsically disordered proteins (IDPs) are based on either the occurrence of long disordered regions or the fraction of disordered residues in the sequence.
Sérgio Forcelloni, Andrea Giansanti
exaly   +3 more sources

Intrinsically disordered proteins and proteins with intrinsically disordered regions in neurodegenerative diseases [PDF]

Biophysical Reviews, 2022
Many different intrinsically disordered proteins and proteins with intrinsically disordered regions are associated with neurodegenerative diseases. These types of proteins including amyloid-β, tau, α-synuclein, CHCHD2, CHCHD10, and G-protein coupled ...
Orkid Coskuner Weber, Vladimir Uversky
exaly   +2 more sources

NeProc predicts binding segments in intrinsically disordered regions without learning binding region sequences

Biophysics and Physicobiology, 2020
Intrinsically disordered proteins are those proteins with intrinsically disordered regions. One of the unique characteristics of intrinsically disordered proteins is the existence of functional segments in intrinsically dis­ordered regions.
Satoshi Fukuchi
exaly   +2 more sources

Low Complexity Induces Structure in Protein Regions Predicted as Intrinsically Disordered

Biomolecules, 2022
There is increasing evidence that many intrinsically disordered regions (IDRs) in proteins play key functional roles through interactions with other proteins or nucleic acids. These interactions often exhibit a context-dependent structural behavior.
Miguel Andrade, Pau Bernado, Kristina Kastano   +2 more
exaly   +3 more sources

Ancient Evolutionary Origin of Intrinsically Disordered Cancer Risk Regions

Biomolecules, 2020
Cancer is a heterogeneous genetic disease that alters the proper functioning of proteins involved in key regulatory processes such as cell cycle, DNA repair, survival, or apoptosis.
Matyas Pajkos, Zsuzsanna Dosztányi
exaly   +3 more sources