Deep Learning-Based Comparative Prediction and Functional Analysis of Intrinsically Disordered Regions in SARS-CoV-2. [PDF]
Int J Mol SciIlyas S, Manan A, Lee D.
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Neurogenic locus notch homolog protein 1 (NOTCH 1) SNP informatics coupled with intrinsically disordered regions and post-translational modifications reveals the complex structural crosstalk of Lung Adenocarcinoma (LUAD). [PDF]
Front BioinformJohn P, Sudandiradoss C.
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Potential ER tubular lumen sensing by intrinsically disordered regions.
J Cell SciYorimitsu T, Sato K.
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Intrinsically Disordered Proteins and Proteins With Intrinsically Disordered Regions in Neurodegenerative Diseases [PDF]
Biophysical Reviews, 2022 Many different intrinsically disordered proteins and proteins with intrinsically disordered regions are associated with neurodegenerative diseases. These types of proteins including amyloid-β, tau, α-synuclein, CHCHD2, CHCHD10, and G-protein coupled ...
Orkide Coşkuner-Weber, Vladimir Uversky
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Introduction to Intrinsically Disordered Proteins and Regions
Intrinsically Disordered Proteins, 2019 Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) are fascinating dynamic conformational ensembles that are observed under physiological conditions.
Alan Keith Dunker +2 more
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Classification of Intrinsically Disordered Regions and Proteins
Chemical Reviews, 2014 1.1. Uncharacterized Protein Segments Are a Source of Functional Novelty Over the past decade, we have observed a massive increase in the amount of information describing protein sequences from a variety of organisms.1,2 While this may reflect the diversity in sequence space, and possibly also in function space,3 a large proportion of the sequences ...
Benjamin Lang +2 more
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Intrinsically Disordered Proteins: An Overview
International Journal of Molecular Sciences, 2022 Many proteins and protein segments cannot attain a single stable three-dimensional structure under physiological conditions; instead, they adopt multiple interconverting conformational states.
Hampapathalu A Nagarajaram +1 more
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Intrinsically Disordered Proteins and Intrinsically Disordered Protein Regions
Annual Review of Biochemistry, 2014Intrinsically disordered proteins (IDPs) and IDP regions fail to form a stable structure, yet they exhibit biological activities. Their mobile flexibility and structural instability are encoded by their amino acid sequences. They recognize proteins, nucleic acids, and other types of partners; they accelerate interactions and chemical reactions between ...
Christopher J, Oldfield, A Keith, Dunker
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Functional Roles of Transiently and Intrinsically Disordered Regions Within Proteins
FEBS Journal, 2015 Proteins are structurally heterogeneous and comprise folded regions with variable conformational stabilities and intrinsically disordered protein regions that do not have well-folded structures.
Vladimir Uversky
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