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Interleukin-11: A Multifunctional Cytokine with Intrinsically Disordered Regions
Cell Biochemistry and Biophysics, 2016Cytokine interleukin-11 (IL-11) is a multifunctional protein with diverse roles in the normal cell signaling and in various pathologies. The structure of IL-11 is characterized by a four-helix bundle motif comprising two pairs of antiparallel α-helices arranged in an up-up-down-down configuration.
Eugene A. Permyakov +2 more
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Computational Methods to Predict Intrinsically Disordered Regions and Functional Regions in Them
2023Intrinsically disordered regions (IDRs) are protein regions that do not adopt fixed tertiary structures. Since these regions lack ordered three-dimensional structures, they should be excluded from the target portions of homology modeling. IDRs can be predicted from the amino acid sequences, because their amino acid compositions are different from that ...
Hiroto, Anbo +2 more
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Controlling entropy to tune the functions of intrinsically disordered regions
Current Opinion in Structural Biology, 2014Intrinsically disordered regions (IDRs) are fundamental units of protein function and regulation. Despite their inability to form a unique stable tertiary structure in isolation, many IDRs adopt a defined conformation upon binding and achieve their function through their interactions with other biomolecules.
Tilman, Flock +3 more
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The molecular basis for cellular function of intrinsically disordered protein regions
Nature Reviews Molecular Cell Biology, 2023Alex S Holehouse +2 more
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Intrinsically Disordered Regions Direct Transcription Factor In Vivo Binding Specificity
Molecular Cell, 2020Sagie Brodsky +2 more
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Intrinsically disordered regions are poised to act as sensors of cellular chemistry
Trends in Biochemical Sciences, 2023David Moses +2 more
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Intrinsically disordered proteins in cellular signalling and regulation
Nature Reviews Molecular Cell Biology, 2014Peter E Wright +2 more
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