Results 101 to 110 of about 727,311 (310)

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Introducing the biogeographic species pool

Ecography, 2013
The species pool concept has played a central role in the development of ecological theory for at least 60 yr. Surprisingly, there is little consensus as to how one should define the species pool, and consequently, no systematic approach exists. Because the definition of the species pool is essential to infer the processes that shape ecological ...
Carstensen, Daniel Wisbech, Lessard, Jean-Philippe, Holt, Ben G., Borregaard, Michael Krabbe, Rahbek, Carsten   +4 more
openaire   +2 more sources

Reduced helminth parasitism in the introduced bank vole (Myodes glareolus): More parasites lost than gained

International Journal for Parasitology: Parasites and Wildlife, 2016
Introduced species are often less parasitised compared to their native counterparts and to ecologically similar hosts in the new environment. Reduced parasitism may come about due to both the loss of original parasites and low acquisition of novel ...
Karen C. Loxton, Colin Lawton, Peter Stafford, Celia V. Holland   +3 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Replacement of Cakile edentula with Cakile maritima in New South Wales and on Lord Howe Island [PDF]

, 2013
Two species of Cakile (Brassicaceae) have been introduced to Australia and the genus has been a common feature on the beaches of NSW for over 130 years; Cakile edentula has been present for at least 148 years (in NSW since about 1870), while Cakile ...
Mills, Kevin
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

An Updated Checklist of the Fishes from the Upper Malagarazi (Lake Tanganyika Basin) in Burundi: Implications for an under Implementation Malagarazi Nature Reserve

Diversity
The upper Malagarazi (uM) Basin is situated in Southeastern Burundi and Northwestern Tanzania, and partially covered by the Malagarazi Nature Reserve (MNR).
Anatole Bigirimana, Tchalondawa Kisekelwa, Luis M. da Costa, Donatien R. Muzumani, Christian Mukweze Mulelenu, Emmanuel Abwe, Gaspard Banyankimbona, Emmanuel Vreven   +7 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Classification of non-indigenous species based on their impacts: Considerations for application in marine management [PDF]

, 2015
Assessment of the ecological and economic/societal impacts of the introduction of non-indigenous species (NIS) is one of the primary focus areas of bioinvasion science in terrestrial and aquatic environments, and is considered essential to management.
Gregory Ruiz, MacKenzie, Cynthia,, McKenzie, Cynthia H., Dan Minchin, Hewitt, Chad L, Cook, Elizabeth J.,, Occhipinti-Ambrogia, Anna,, Chad L. Hewitt (471921), Olenin, Sergej,, Henn Ojaveer (222381), João Canning-Clode (227151), Bella S. Galil (244773), Davidson, Alisha D, Galil, Bella S, Ruiz, Gregory,, Campbell, Marnie L., Carlton, James T, Henn Ojaveer, João Canning-Clode, Marnie L. Campbell (471920), Hewitt, Chad L., Ruiz, Gregory, Marnie L Campbell, Anders Jelmert (723927), Ojaveer, Henn, Anders Jelmert, Dan Minchin (723929), Gregory Ruiz (723930), Anna Occhipinti-Ambrogi, Cook, Elizebeth J., Marchini, Agnese, Minchin, Dan,, Campbell, Marnie L.,, Carlton, James T.,, Sergej Olenin (242674), Hewitt, Chad L.,, Davidson, Alisha D.,, Mckenzie, Cynthia H, Cook, Elizabeth J., Cynthia H. McKenzie (723928), Galil, Bella S.,, Campbell, Marnie L, James T Carlton, Agnese Marchini (311399), Alisha D. Davidson (723926), James T. Carlton (336663), Jelmert, Anders,, Carlton, James T., Alisha D Davidson, Minchin, Dan, Chad L Hewitt, Occhipinti-Ambrogi, Anna, Anna Occhipinti-Ambrogi (696729), Elizabeth J. Cook (313089), Jelmert, Anders, Ojaveer, Henn,, Cynthia H McKenzie, Cook, Elizabeth J, Canning-Clode, João, Agnese Marchini, Canning Clode, João, Elizabeth J Cook, Sergej Olenin, Olenin, Sergej, Davidson, Alisha D., Bella S Galil, Canning-Clode, João,, Marchini, Agnese,, OCCHIPINTI, ANNA CARMEN, Galil, Bella S.   +69 more
core   +1 more source