Results 101 to 110 of about 6,411,354 (254)
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Acta Scientiarum: Biological Sciences, 2017 Achatina fulica, known as Giant African Snail (GAS), was introduced in Brazil as a substitute for the European escargot, Helix aspersa maxima. However, its cultivation was abandoned and the mollusk became an invasive species, found throughout Brazil ...
Márcia Aparecida Andreazzi +5 more
doaj +1 more source
Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk
Molecular Oncology, EarlyView.Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley +1 more source
ECONOMICS OF DETECTION AND CONTROL OF INVASIVE SPECIES: WORKSHOP HIGHLIGHTS [PDF]
Invasive species are species that are not native to an ecosystem, and when introduced into the new ecosystem, they cause economic or environmental damage.
Koo, Won W., Mattson, Jeremy W.
core
International Journal for Parasitology: Parasites and Wildlife, 2016 Introduced species are often less parasitised compared to their native counterparts and to ecologically similar hosts in the new environment. Reduced parasitism may come about due to both the loss of original parasites and low acquisition of novel ...
Karen C. Loxton +3 more
doaj +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Introduced weeds pollinated by introduced bees: Cause or effect?
, 2003 In the present review we attempt to synthesize evidence for a causative relationship between the presence of non-native bee pollinators and the successful establishment and spread of introduced weed species.
Goulson, Dave +3 more
core +1 more source
Exploring microplastic pollution in a Mediterranean river: The role of introduced species as bioindicators. [PDF]
Heliyon, 2023 Koutsikos N +5 more
europepmc +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source