Results 101 to 110 of about 317,196 (344)

The RNA-binding protein hnRNPLL induces a T cell alternative splicing program delineated by differential intron retention in polyadenylated RNA

Genome Biology, 2014
BackgroundRetention of a subset of introns in spliced polyadenylated mRNA is emerging as a frequent, unexplained finding from RNA deep sequencing in mammalian cells.ResultsHere we analyze intron retention in T lymphocytes by deep sequencing ...
Vicky Cho, Yan Mei, A. Sanny, S. Chan, A. Enders, E. Bertram, A. Tan, C. Goodnow, T. Andrews   +8 more
semanticscholar   +1 more source

Highly Customizable Scaffold‐Type 3D Microelectrode Array Platform for Design and Analysis of the 3D Neuronal Network In Vitro

Advanced Functional Materials, EarlyView.
An innovative fabrication platform for 3D microelectrode arrays (MEAs) is presented, utilizing a 3D printer and the capillary action of electrically conductive inks. This approach enables the simple and versatile fabrication of 3D MEAs with complex structures.
Dongjo Yoon, Yoonkey Nam
wiley   +1 more source

Intron‐dependent evolution: Preferred types of exons and introns [PDF]

FEBS Letters, 1987
Exon insertions and exon duplications, two major mechanisms of exon shuffling, are shown to involve modules that have introns of the same phase class at both their 5′‐ and 3′‐ends. At the sites of intronic recombinations exon insertions and duplications create new introns which belong to the same phase class as the recipient introns.
openaire   +3 more sources

Peptide Display Directed Assembly of Biopolymer Core–Silica Shell Particles

Advanced Healthcare Materials, EarlyView.
Bacterial cells are engineered to produce biopolyester particles displaying peptides mediating growth of silica. Peptide‐coated biopolyester particles are treated with silica precursors and silica shell formation is studied. Transmission electron microscopy shows silica‐coated BPs which are formed after the silicification treatment. Characterization of
Deeptee Chandrashekhar Pande, Frank Sainsbury, Bernd H. A. Rehm   +2 more
wiley   +1 more source

Power and limitations of the chloroplast trnL (UAA) intron for plant DNA barcoding

Nucleic Acids Research, 2006
DNA barcoding should provide rapid, accurate and automatable species identifications by using a standardized DNA region as a tag. Based on sequences available in GenBank and sequences produced for this study, we evaluated the resolution power of the ...
P. Taberlet, É. Coissac, F. Pompanon, L. Gielly, C. Miquel, A. Valentini, T. Vermat, G. Corthier, C. Brochmann, E. Willerslev   +9 more
semanticscholar   +1 more source

Single Administration of AAV‐mAtp6v1b2 Gene Therapy Rescues Hearing and Vestibular Disorders Caused by Atp6v1b2‐Induced Lysosomal Dysfunction in Hair Cells

Advanced Science, EarlyView.
Wei et al. establish a hair cell‐specific conditional knockout mouse model (Atp6v1b2fl/fl;Atoh1Cre/+), and demonstrate the importance of Atp6v1b2 for hair cell through maintaining the survival of lysosomes. A single administration of AAV‐ie‐Eh3‐mAtp6v1b2 through scala media at P0‐P2 realizes function compensation and restores hearing and balance ...
Gege Wei, Shiwei Qiu, Xue Gao, Lu Zheng, Yijin Chen, Ying Ma, Haifeng Feng, Jinyuan Yang, Guojie Dong, Huiyi Nie, Weihao Zhao, Xiaoge Li, Guangqin Wang, Wei Xiong, Pu Dai, Yongyi Yuan   +15 more
wiley   +1 more source

Circularly permuted tRNA genes: their expression and implications for their physiological relevance and development.

Frontiers in Genetics, 2014
A number of genome analyses and searches using programs that focus on the RNA-specific bulge-helix-bulge (BHB) motif have uncovered a wide variety of disrupted tRNA genes.
Akiko eSoma
doaj   +1 more source

GDC: Integration of Multi‐Omic and Phenotypic Resources to Unravel the Genetic Pathogenesis of Hearing Loss

Advanced Science, EarlyView.
Overview of the Genetic Deafness Commons (GDC), integrating data from the Chinese Deafness Genetics Consortium (CDGC) and 51 public databases. The GDC provides tools for variant search, functional predictions, and gene‐disease visualization, offering insights into 201 hearing loss genes and facilitating novel gene discovery and clinical applications ...
Hui Cheng, Xuegang Wang, Mingjun Zhong, Jia Geng, Wenjian Li, Kanglu Pei, Jing Wang, Lanchen Wang, Yu Lu, Jing Cheng, Fengxiao Bu, Huijun Yuan   +11 more
wiley   +1 more source

Widespread Separation of the Polypyrimidine Tract From 3′ AG by G Tracts in Association With Alternative Exons in Metazoa and Plants

Frontiers in Genetics, 2019
At the end of introns, the polypyrimidine tract (Py) is often close to the 3′ AG in a consensus (Y)20NCAGgt in humans. Interestingly, we have found that they could also be separated by purine-rich elements including G tracts in thousands of human genes ...
Hai Nguyen, Hai Nguyen, Jiuyong Xie
doaj   +1 more source

Cryptic Splicing of GAP43 mRNA is a Novel Hallmark of TDP‐43‐Associated ALS and AD

Advanced Science, EarlyView.
TDP‐43 dysfunction disrupts RNA processing, inducing cryptic exon 4a1 inclusion in GAP43 and reducing its protein levels. This aberrant splicing impairs axonal regeneration and contributes to neurodegeneration in ALS and AD. RNA‐seq of patient brains reveals GAP43 downregulation and 4a1 upregulation, identifying cryptic exon 4a1 as a potential ...
Mingming Yang, Qi Wang, Dongkun Kang, Shijia Wang, Yanli Jiang, Jian‐Zhi Wang, Chen Ming, Rong Liu, Jianlan Gu, Xiaochuan Wang   +9 more
wiley   +1 more source