Results 131 to 140 of about 416,899 (328)
Advanced Science, EarlyView.ARID1A is frequently mutated in both non‐malignant tissues and cancers, but its role in tumor development after exposure to genotoxic carcinogen remains unclear. It is found that aristolochic acid I accelerated liver tumorigenesis in ARID1A‐deficient context by impairing nucleotide excision repair and enhancing carcinogen bioactivation, revealing key ...
Lan Wang +8 more
wiley +1 more source
Advanced Science, EarlyView.Our study reveals a novel mechanism by which palmitoylation regulates ferroptosis and enzalutamide resistance in prostate cancer. Under enzalutamide resistance, the FOXA1/CXXC5/TET2 complex induces aberrant upregulation of ZDHHC2, which subsequently suppresses ferroptosis by mediating S‐palmitoylation of USP19 and degradation of ACSL4 protein in CRPC ...
Shuai Shao +10 more
wiley +1 more source
Advanced Science, EarlyView.Red‐light‐activated Ir1 overcomes hypoxia tolerance and adapts to the immunosuppressive tumor microenvironment, converting immunologically cold tumors into inflamed hot microenvironments. This conversion is driven by synergistic induction of immunogenic cell death through coordinated ferroptosis‐necroptosis pathways and spatiotemporally controlled ...
Long‐Bo Yu +8 more
wiley +1 more source
Advanced Science, EarlyView.These findings elucidated the crucial role of the “SVs‐3D genome remodeling‐epigenetic modifications‐gene expression” cascade regulatory network in cotton fiber domestication, offering both a theoretical foundation and genetic resources for molecular design breeding in fiber crops.
Lei Shao +11 more
wiley +1 more source
A trans-acting suppressor restores splicing of a yeast intron with a branch point mutation. [PDF]
, 1987 Joseph Couto +3 more
openalex +1 more source
Integrative Omics Defines Metabolic Biomarkers and Genetic Regulatory Mechanisms of Mortality Risk
Advanced Science, EarlyView.Understanding mortality mechanisms remains a fundamental challenge. Through multi‐omics analysis of a three‐generation chicken model, are identified 45,585 mQTLs and establish a 16‐metabolite predictor of mortality. An inflammation‐growth trade‐off and evolutionarily conserved pathways involving butyrate–microbiota interactions and L‐cysteine's dual ...
Peihao Liu +10 more
wiley +1 more source
Replication-dependent activation of the adenovirus major late promoter is mediated by the increased binding of a transcription factor to sequences in the first intron [PDF]
, 1989 Pidder Jansen‐Dürr +2 more
openalex +1 more source
Stromal Cell‐Mast Cell Communication Orchestrates Anti‐Viral Immunity in the Meninges
Advanced Science, EarlyView.This study delineates the spatial distribution and postnatal maturation of meningeal mast cells and uncovers their essential role in antiviral immunity. Using genetic models, mast cells are shown to promote CD8⁺ T cell infiltration and viral clearance via IL‐33 receptor signaling and synergistic activation by IL‐33 and ATP from infected stromal cells ...
Qingqing Li +7 more
wiley +1 more source
PhytoFrontiersA pathogen causing disease on yellow nutsedge (Cyperus esculentus) growing in and near irrigated areas of onion seed and bulb fields in Idaho and Oregon during July and August 1996 was morphologically and molecularly characterized.
Tyler B. Bourret +5 more
doaj +1 more source
Deficiency in mRNA splicing in a cytochrome c mutant of neurospora crassa [PDF]
, 1987 Molecular cloning and characterization of cytochrome c cDNA clones of Neurospora crassa wild-type (74A) and a cytochrome c-deficient mutant (cyc1-1) are described.
Neupert, Walter +2 more
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